China-Japan Friendship Hospital

Investigation And Analysis Of The Current Situation Of Medical Equipment Allocation In Tertiary And Secondary Hospitals

Abstract Medical equipment is crucial for medical institutions, yet there are issues in its allocation. This study analyzed the configuration of medical equipment in Chinese public hospitals, covering large and life support equipment, domestic equipment proportion, etc. Using que...

Association between post-exercise heart rate recovery and one-year clinical deterioration in COPD: a retrospective longitudinal analysis

The application of cardiopulmonary exercise testing (CPET) for assessing heart rate recovery at 1 min (HRR1) is of significant clinical value in evaluating disease severity, cardiovascular risk, and prognosis in patients with cardiovascular diseases. However, its utility in patie...

Development and validation of an interpretable machine learning model for predicting ICU prognosis in critically ill patients with invasive pulmonary aspergillosis: a multicenter study

Invasive pulmonary aspergillosis (IPA) is associated with elevated mortality among intensive care unit (ICU) patients. Early prognostic risk stratification is of great importance; however, validated clinical tools remain limited. This study aimed to develop and validate an interp...

Development of a Three‐Layered Fascial Architecture in the Rabbit Carotid Sheath: Histological Findings Consistent With Mechanical Influences

Current understanding of the fascial structures within the human carotid sheath (CS) is largely based on static anatomical descriptions, with limited knowledge of their dynamic developmental process. This study aimed to characterise the developmental progression of the fascial ar...

Molecular subtyping of colorectal cancer based on aging-related gene network perturbation analysis and functional validation of MAP1B

Molecular heterogeneity of colorectal cancer (CRC) remains a major barrier to precision therapy. In this study, we integrated eight public aging-related resources to construct an aging-related gene set and performed network perturbation analysis on the TCGA CRC cohort using a Rea...

Stratified meta-analysis of rodent diabetic neuropathy nerve transcriptomes identifies a down-regulated structural core

This record contains the derived data and analysis code for the study "Stratified meta-analysis of rodent diabetic neuropathy nerve transcriptomes identifies a down-regulated structural core" (manuscript submitted to Disease Models & Mechanisms, 2026). Twelve rodent (mouse and ra...

Beyond Carbapenemases: Chromosomal Resistance Mechanisms and Carbapenemase Type Determine Susceptibility to Novel β-Lactam/β-Lactamase Inhibitor Combinations and Cefiderocol in Carbapenem-Resistant Pseudomonas aeruginosa from China

Background: β-lactam/β-lactamase inhibitor combinations (BL/BLIs) and siderophore cephalosporin serve as critical polymyxin alternatives for carbapenem-resistant Pseudomonas aeruginosa (CRPA). However, systematic multicenter clinical data from China and the resistance mechanisms...

Navigation‐Assisted Pure Endoscopic Transoral Styloidectomy for Recurrent Eagle Syndrome: A Pictorial Essay

ABSTRACT Background Complete resection of the styloid process at its skull‐base origin is challenging in recurrent Eagle syndrome because of postoperative fibrosis, distorted anatomy, and proximity to the internal carotid artery ( ICA ). Methods Bilateral dissections of two silic...

The prognostic value of sarcopenia combined with preoperative C-reactive protein-albumin ratio in patients with gastric signet ring cell carcinoma

Abstract Background Gastric signet ring cell carcinoma (GSRCC) is an aggressive subtype of gastric cancer with poor prognosis. Sarcopenia and systemic inflammation have been linked to adverse outcomes in malignancies. This study aimed to evaluate the prognostic value of sarcopeni...

CACA guidelines for the management of adult cancer pain

Abstract Cancer pain, one of the most prevalent and distressing symptoms in cancer patients, is closely associated with cancer diagnosis, therapeutic interventions, quality of life, and survival outcomes. Effective cancer pain management requires multidisciplinary collaborative a...

Beyond cholesterol: targeting ceramide signaling in cardiorenal metabolic crosstalk

Cardiovascular-Kidney-Metabolic (CKM) syndrome is associated with increased risks of cardiovascular mortality and target organ failure. Despite optimal lipid-lowering therapies, patients remain at substantial residual risk for adverse cardio-renal outcomes. Conventional cholester...

Mechanisms and therapeutic strategies of asthma: from bench to bedside

Asthma is a heterogeneous chronic airway disease arising from a complex interplay of genetic susceptibility and environmental exposures. Key pathobiological features include dysregulated immune responses (particularly type 2 inflammation), structural airway remodeling, and mucus...

Postoperative pulmonary complications after high-altitude thoracic surgery requiring one-lung ventilation: a single-centre retrospective cohort study

Abstract Background Postoperative pulmonary complications (PPCs) are common adverse outcomes after thoracic surgery and one-lung ventilation (OLV). Their reported incidence varies with endpoint definition and ascertainment. Lower inspired oxygen partial pressure may alter periope...

Tocilizumab in refractory anti-synthetase syndrome-associated interstitial lung disease:a phenotype-stratified cohort study

Anti-synthetase syndrome-associated ILD (ASyS-ILD) spans a spectrum from active inflammation to established fibrosis; IL-6 pathway involvement supports a rationale for tocilizumab, yet phenotype-specific efficacy data are lacking. Thirty-two patients with refractory ASyS-ILD rece...

Structure-based design of peptide inhibitors targeting the SPSB2–iNOS interaction: a computational approach to modulating nitric oxide signaling

Dysregulation of inducible nitric oxide synthase (iNOS) plays a central role in inflammatory diseases, cancer, and neurodegeneration due to excessive nitric oxide (NO) production. Suppressor of Cytokine Signaling Box Protein 2 (SPSB2) is a key negative regulator of iNOS through s...