China-Japan Friendship Hospital

The prognostic value of sarcopenia combined with preoperative C-reactive protein-albumin ratio in patients with gastric signet ring cell carcinoma

Abstract Background Gastric signet ring cell carcinoma (GSRCC) is an aggressive subtype of gastric cancer with poor prognosis. Sarcopenia and systemic inflammation have been linked to adverse outcomes in malignancies. This study aimed to evaluate the prognostic value of sarcopeni...

CACA guidelines for the management of adult cancer pain

Abstract Cancer pain, one of the most prevalent and distressing symptoms in cancer patients, is closely associated with cancer diagnosis, therapeutic interventions, quality of life, and survival outcomes. Effective cancer pain management requires multidisciplinary collaborative a...

Beyond cholesterol: targeting ceramide signaling in cardiorenal metabolic crosstalk

Cardiovascular-Kidney-Metabolic (CKM) syndrome is associated with increased risks of cardiovascular mortality and target organ failure. Despite optimal lipid-lowering therapies, patients remain at substantial residual risk for adverse cardio-renal outcomes. Conventional cholester...

Mechanisms and therapeutic strategies of asthma: from bench to bedside

Asthma is a heterogeneous chronic airway disease arising from a complex interplay of genetic susceptibility and environmental exposures. Key pathobiological features include dysregulated immune responses (particularly type 2 inflammation), structural airway remodeling, and mucus...

Postoperative pulmonary complications after high-altitude thoracic surgery requiring one-lung ventilation: a single-centre retrospective cohort study

Abstract Background Postoperative pulmonary complications (PPCs) are common adverse outcomes after thoracic surgery and one-lung ventilation (OLV). Their reported incidence varies with endpoint definition and ascertainment. Lower inspired oxygen partial pressure may alter periope...

Tocilizumab in refractory anti-synthetase syndrome-associated interstitial lung disease:a phenotype-stratified cohort study

Anti-synthetase syndrome-associated ILD (ASyS-ILD) spans a spectrum from active inflammation to established fibrosis; IL-6 pathway involvement supports a rationale for tocilizumab, yet phenotype-specific efficacy data are lacking. Thirty-two patients with refractory ASyS-ILD rece...

Structure-based design of peptide inhibitors targeting the SPSB2–iNOS interaction: a computational approach to modulating nitric oxide signaling

Dysregulation of inducible nitric oxide synthase (iNOS) plays a central role in inflammatory diseases, cancer, and neurodegeneration due to excessive nitric oxide (NO) production. Suppressor of Cytokine Signaling Box Protein 2 (SPSB2) is a key negative regulator of iNOS through s...