China-Japan Friendship Hospital

Paradoxical Association of Body Mass Index With Occurrence and Mortality of Venous Thromboembolism in Hospitalized Patients: A National Hospital‐Based Cohort Analysis

Background The association between body mass index (BMI) and venous thromboembolism (VTE) occurrence and mortality is controversial. This study aimed to investigate the association of BMI with VTE occurrence and mortality and explore the consistency across age, sex, and medical s...

Rhein-induced free fatty acid generation cooperates with silver ions for biofilm-infected diabetic wound healing

Diabetic foot infection (DFI) significantly increases the risks of hospitalization and amputation, with biofilm infections caused by methicillin-resistant Staphylococcus aureus (MRSA) and carbapenem-resistant Escherichia coli (CREC) being key drivers of treatment failure. Here, w...

Baseline and longitudinal trajectories of peak expiratory flow in relation to incident cognitive impairment among older adults: Evidence from CHARLS

Background Previous studies, including CHARLS analyses, have linked lower peak expiratory flow (PEF) with cognitive decline. Evidence regarding incident score-based cognitive impairment, longitudinal PEF patterns, and incremental prediction remains limited. Objective To examine a...

Evaluation of acute FGF2 and PRDX3 for long COVID prediction across cohorts and proteomic platforms

Abstract Blood proteins measured during acute COVID-19 may help predict Long COVID, but models may fail when moved between cohorts and proteomic platforms. We fitted a reference model using age and sex (C0) in Su/INCOV and a protein model that also included FGF2 and PRDX3 (C2). T...

Evaluating the efficacy of pressure microcatheters for fractional flow reserve measurement in chronic thromboembolic pulmonary hypertension: a comparative study

This study aimed to compare the efficacy and procedural performance of pressure microcatheters and pressure guidewires for fractional flow reserve (FFR) measurement in patients with chronic thromboembolic pulmonary hypertension (CTEPH) undergoing balloon pulmonary angioplasty (BP...

Exploratory thyroid ultrasound–computed tomography synthesis using anatomy-preserving contrastive unpaired translation

OBJECTIVES: When ultrasound (US) and computed tomography (CT) are both clinically indicated, unpaired image translation may support model development but cannot replace either examination. We evaluated Anatomy-Preserving Contrastive Unpaired Translation (AP-CUT), a CUT-based fram...

Multi-cell death gene signature predicts lung adenocarcinoma prognosis and reveals FURIN regulates ferroptosis via NRF2-xCT-GPX4 axis

FURIN, a proprotein convertase, has been implicated in tumor progression. Nevertheless, how it contributes to lung adenocarcinoma (LUAD) and ferroptosis is still not well understood. We investigated FURIN expression and its prognostic value using the TCGA-LUAD cohort, CPTAC, and...

Dynamic cardio-renal-metabolic trajectories identify sepsis subphenotypes for individualized management: a cross-population cohort study

Sepsis heterogeneity remains a major barrier to precision medicine. Although cardio-renal-metabolic interactions critically influence outcomes, their dynamic evolution is rarely integrated into clinical phenotyping. We aimed to identify distinct sepsis subphenotypes based on dyna...

Association of depressive symptoms with retinal layer thickness: insights from the population-based Beijing eye study 2011

The aim of this study is to investigate the association between depressive symptoms and retinal layer thickness in a population-based adult Chinese cohort. This population-based, cross-sectional study included 2127 eyes of 2127 participants of Beijing Eye Study 2011, free of any...

The ventilation–perfusion differential index assists target lobe selection and improves V/Q redistribution for endobronchial valve lung volume reduction: a prospective study

Identifying the optimal target lobe remains a challenge for bronchoscopic lung volume reduction (BLVR) with endobronchial valves (EBVs). The ventilation/perfusion differential index (VQDI) has been identified as a possible tool for target lobe selection in BLVR. Twenty-four indiv...

Effects of combined training on inflammatory biomarkers in middle-aged and older adults: a systematic review and meta-analysis

Chronic low-grade inflammation is a key factor in aging and age-related diseases. With population aging, effective anti-inflammatory interventions were increasingly needed. Combined aerobic and resistance training (CART) has emerged as a promising non-pharmacological approach; ho...

Porous Polymeric Materials for Cell Delivery and Regenerative Therapy: Design Principles, AI‐Assisted Optimization, and Clinical Translation

ABSTRACT Cell therapy is increasingly recognized as a cornerstone of 21st‐century medical innovation, but its success heavily relies on the effective delivery of therapeutic cells to the target site while maintaining their viability and functionality. Traditional intravenous inje...

Geometric morphological parameters from cardiac magnetic resonance imaging in assessment of chronic pulmonary thromboembolism, a prospective pilot study

Abstract Objective The role of geometric-morphological parameters derived from cardiac magnetic resonance imaging (CMR) in assessing and stratifying chronic pulmonary thromboembolism (CPTE) remains unclear. Material and methods We prospectively enrolled 53 CPTE patients (16 with...

Association of the C-reactive protein-triglyceride glucose index with incident hypertension across glycemic status: a longitudinal cohort study

The C-reactive protein-triglyceride glucose index (CTI) is a composite indicator that integrates systemic inflammation, lipid metabolism, and glucose metabolism. Previous studies have reported an association between CTI and incident hypertension, but evidence across different gly...

Segmental cervical instability, heart rate variability, and sympathetic symptoms in cervical spondylosis: an exploratory retrospective cohort study

Sympathetic symptoms in cervical spondylosis represent a diagnostically challenging entity. Whether such symptoms arise from direct mechanical irritation of the cervical sympathetic trunk or from systemic autonomic dysregulation remains highly contested. This study aimed to inves...

Impact of periodontal indices and therapeutic interventions on COPD: a systematic review with meta-analysis

Objectives This systematic review and meta-analysis aimed to evaluate the association between periodontal disease and chronic obstructive pulmonary disease (COPD), examine periodontal parameters associated with COPD, and assess the effects of periodontal treatment on COPD-related...

Ultra‐Bright and pH‐Stable DBCO‐Capped Gold Clusters as NIR‐II Gram‐Typing Nanoprobes for Deciphering Microgravity‐Related Gut Bacterial Restructuring in Rats

ABSTRACT Microgravity‐induced alterations of gut microbiota are implicated in gastrointestinal pathology during spaceflight, yet conventional 16S rRNA sequencing lacks the resolution to remotely track real‐time spatial dynamics of in situ bacteria. Here, we develop ultrabright, p...

OGTT ‐Derived β‐Cell Function–Based Stratification of 2‐Year Glycaemic Transitions in Chinese Adults With Prediabetes

ABSTRACT Aims Prediabetes is heterogeneous, with variable progression to diabetes or reversion to normoglycemia. We evaluated whether the insulin secretion‐sensitivity index‐2 (ISSI‐2), an oral glucose tolerance test (OGTT)‐derived integrated surrogate of β‐cell function relative...

Prenatal exposure to gestational diabetes mellitus increases developmental defects of enamel in offspring: a retrospective cohort study in China

Abstract Objectives Gestational diabetes mellitus (GDM) is increasingly prevalent in China, yet its impact on offspring dental development remains unclear. This cohort study examined whether maternal GDM is associated with developmental defects of enamel (DDE) in primary teeth an...

Patient-reported somatic symptoms and lifestyle factors associated with psychological distress in patients with papillary thyroid carcinoma: a cross-sectional analysis

Psychological distress is common among patients with papillary thyroid carcinoma (PTC), yet the relative associations of clinicopathological characteristics and patient-reported somatic symptoms and lifestyle factors to preoperative distress remain insufficiently understood. This...