Children's Hospital of Fudan University

Vascular device practices in extremely preterm infants: an international cross-sectional survey

Abstract Objective To explore global practices in vascular device selection, securement, and monitoring for extremely preterm infants, and to assess regional variation. Study design A web-based cross-sectional survey was completed by one respondent per neonatal unit. Result We re...

Different concentrations of atropine in children with high myopia: a 2-year multicenter double-blind, randomized controlled trial

High myopia in children risks irreversible visual impairment, yet optimal interventions remain debated. This multicenter double-blind, randomized-controlled trial aims to evaluate the effect and safety of different atropine eyedrops for myopia control in children with high myopia...

Helicobacter pylori-related peptic ulcer presenting as isolated iron deficiency anemia without typical gastrointestinal complaints in a child: a case report

Iron deficiency anemia (IDA) is the most common form of nutritional anemia in children worldwide. Helicobacter pylori (H. pylori) infection is a well-recognized contributor to pediatric IDA, through mechanisms including bleeding from peptic ulcers or erosions and impaired iron ab...

Plasma interleukin-1 receptor antagonist in pediatric patients as a potential biomarker for sepsis-associated acute kidney injury: a cohort study

Our goal is to evaluate the potential of interleukin-1 receptor antagonist (IL-1Ra) as a biomarker for sepsis-associated acute kidney injury (SA-AKI). Specifically, we aim to explore the correlation between acutely elevated endogenous IL-1Ra and SA-AKI, and to identify the potent...

Salvage stent implantation for anastomotic stenosis after coronary artery bypass grafting in Kawasaki disease: a case report

Abstract Giant coronary artery aneurysms (CAAs) secondary to Kawasaki disease (KD) carry a poor prognosis, mainly due to the risk of severe stenosis and myocardial infarction. While revascularization options including coronary artery bypass grafting (CABG) and percutaneous corona...

Maternal and fetal risk factors for hypospadias: a hospital-based case-control study in Southern China

Hypospadias is a frequent congenital anomaly in male infants, defined by the urethral meatus opening on the ventral surface of the penis. Although its causes have been examined for many years, the underlying aetiology in most affected children remains unclear. Maternal factors su...

Gallbladder abnormalities in Kawasaki disease: a single-center case series study

Kawasaki disease is a systemic vasculitis predominantly affecting children, which can involve multiple organ systems, including the gallbladder. Gallbladder abnormalities in KD, particularly in incomplete cases with gastrointestinal symptoms, are often underdiagnosed. These abnor...

Incidence, prevalence and outcomes of neonatal sepsis: a population-based cohort study of hospitalized neonates in Huai’an, China

Background This study aims to estimate the incidence, prevalence of morbidity and mortality rate (MR), associated risks, and the applicability of neonatal sequential organ failure assessment (nSOFA), of neonatal sepsis from a database of all hospitalized infants in a representati...

Common SAEs and their impact on the prognosis of children treated with the CCCG-ALL-2015 protocol: a retrospective multicentre Chinese study

This study was intended to evaluate common serious adverse events (SAEs) and analyze their effects on the prognosis of acute lymphoblastic leukemia (ALL) children. We retrospectively collected the data of 7640 consecutive ALL children with/ without SAEs who were enrolled in CCCG-...

Prophylactic administration of caffeine reduces bronchopulmonary dysplasia in very preterm infants: a single center, randomized controlled trial

Caffeine has been widely used to prevent apnea in very preterm infants (VPIs), but it is not clear whether prophylactic administration of caffeine can prevent bronchopulmonary dysplasia (BPD) in VPIs. This single-center, randomized clinical trial recruited very preterm neonates (...

Projected burden of humid-heat on paediatric asthma in Shanghai under climate change scenarios: A time-series study

Climate change is intensifying the frequency and severity of extreme heat events. While the impact of temperature on respiratory health is well-documented, the synergistic effects of combined heat and humidity are less clear, especially for children, a population with heightened...

MOCR-DB: The Multi-Omics Causal Resource Database for Genetic Correlation, Causal Inference, and Functional Interpretation

Abstract Genome-wide association studies (GWAS) have revealed extensive polygenic signals and overlapping genetic architectures across human traits, creating a need for resources that connect trait-level genetic relationships with gene-level functional evidence. Here, we develope...

Trends in Pathogens Causing Late-Onset Sepsis in Very Preterm Infants: 2010–2023

OBJECTIVE To examine long-term trends in overall and pathogen-specific late-onset sepsis (LOS) incidence among very preterm infants (VPIs) in a statewide, population-based network. METHODS We analyzed data for infants born at 22 to 31 weeks’ gestation in the California Perinatal...

Longitudinal Analysis of Urine Metabolomics in Preterm Infants Based on UHPLC-MS/MS Technique

Background: The metabolic characteristics of preterm infants in the early postnatal period are closely linked to their growth and development. Investigating the corresponding metabolic changes that occur during the early postnatal maturation process of preterm infants may help im...

Microplastics in pediatric asthma: Clinical associations with disease severity

Background Respiratory exposure to microplastics (MPs) is increasingly recognized as a potential contributor to chronic airway disease, but the MPs burden in children with asthma and its relationship to disease remain poorly defined. Methods In this cross-sectional study, sputum...

Clinical infection and molecular characteristics of carbapenem-resistant organisms among children in China, 2016-2025

Carbapenem-resistant organisms (CROs) pose a severe health threat to pediatric patients. We aimed to investigate the epidemiology, clinical infection, and molecular profiles of CROs in Chinese children from 2016 to 2025. We retrospectively analyzed 3655 non-duplicate CRO strains...

Subcutaneous Belimumab Demonstrates Consistent Steady-State Pharmacokinetics and is Well Tolerated in Paediatric Patients with SLE in China: An Open-Label Study

This study assessed pharmacokinetics and safety of subcutaneous (SC) belimumab in Chinese paediatric patients with systemic lupus erythematosus (cSLE) who previously received intravenous (IV) belimumab; only the IV form is approved for cSLE in China. This single-arm, open-label,...

AI-Assisted Viable Digital Array for Rapid Quantification of Bacteria in Pediatric Urinary Tract Infections

Abstract Urinary tract infections (UTIs) are among the most common bacterial infections in neonates and infants, and delayed diagnosis can lead to severe complications. Rapid, quantitative detection of viable bacteria at the point of care remains a critical unmet need. Here, we p...

Multi-level static and dynamic graph-theoretical analyses of resting-state functional networks in a Chinese cohort of preterm neonates

Preterm birth influences early functional brain maturation at term-equivalent age. Using resting-state functional magnetic resonance imaging from a large Chinese neonatal cohort (62 term-born and 107 preterm neonates), we examined static and dynamic network organization using mul...