Chiang Mai University

Integrating phytometabolomics, Drosophila proteomics, and network pharmacology to evaluate the metabolic effects of Citrus maxima peel extract following bisphenol a and benzyl butyl phthalate exposure

Bisphenol A (BPA) and benzyl butyl phthalate (BBP) are endocrine-disrupting chemicals (EDCs) with reported obesogenic activity, attracting interest in their potential contribution to obesity and metabolic dysfunction. This study investigated the effect of pomelo peel extract (PPE...

Phenotypic Associations in Resistance to Medically Important Antibiotics Among Highly Resistant Bacteria Isolated from Cambodian Dairy Farms

Antimicrobial resistance (AMR) is recognized by global health authorities as one of the foremost public health and development challenges confronting humanity today, leading the WHO to establish categories of medically important antibiotics for humans and animals. On farms with a...

Gold Nanoparticle-Enabled Cancer Therapy: Translational Design Rules for Photothermal–Immunotherapy and Multimodal Precision Oncology

Gold nanoparticles (AuNPs) are versatile cancer-therapy platforms with tunable plasmonic properties, high atomic number, accessible surface chemistry, and potential for integration into theranostic systems. By controlling size, morphology, surface composition, and cargo-loading s...

Safety and Efficacy of Acute Normovolemic Hemodilution in Female Patients

Importance Female patients undergoing cardiac surgery have a higher transfusion burden, yet they remain underrepresented in randomized clinical trials. Although the ANH trial showed no significant reduction in the proportion of patients receiving allogeneic blood transfusions wit...

Reactive Blends of Thermoplastic Starch and Epoxidized Natural Rubber with Chlorhexidine Gluconate Compatibilizer and Antimicrobial Agent

In this study, reactive blending of thermoplastic starch (TPS), chlorhexidine gluconate (CHG), and epoxidized natural rubber (ENR) was performed. CHG was incorporated to improve compatibility via crosslinking and antimicrobial properties, whereas ENR was added to improve the flex...

Production Efficiency in Pig Farming in Thailand: A Copula-Based Frontier Model

This study evaluates the technical efficiency of pig production in Nakhon Si Thammarat Province, Thailand, using a copula-based stochastic frontier framework that relaxes the conventional assumption of independence between stochastic noise and technical inefficiency. Farm-level d...

Residual rhythms and sustainable sense of place: lessons learned from a Thai urban neighborhood

This study proposes an alternative approach to creating and sustaining a sense of place based on the rhythms of everyday life in Thai urbanism. In Thai urbanism, a sense of place is not always established and maintained through historical landmarks, physical symbols, or environme...

Diagnostic Performance of Ultrasonographic Median Nerve Cross-Sectional Area for Carpal Tunnel Syndrome in Wheelchair Users With Spinal Cord Injury

OBJECTIVE: To evaluate the diagnostic performance of ultrasonographic median nerve cross-sectional area (CSA-M) for carpal tunnel syndrome (CTS) in wheelchair users with spinal cord injury (SCI), and to identify clinically relevant diagnostic cutoff values. DESIGN: Prospective, c...

Sesamin Attenuates Interleukin-1β-Induced Inflammation in Human Synovial Cells: Involvement of the Nrf2/HO-1 Pathway and NLRP3 Expression

Abstract Osteoarthritis (OA) is a progressive joint disease characterized by cartilage destruction and is increasingly recognized as involving chronic low-grade inflammation. Synovitis contributes to OA progression through the production of proinflammatory mediators and reactive...

Effects of interface modality and gamification on learning, engagement, and performance in simulation-based training

This study investigates the effects of interface modality (PC vs. VR) and gamification on learning and performance in a simulation-based training environment. A 2 × 2 factorial experiment (N = 120) was conducted to examine their effects on knowledge, engagement, presence, and pro...

Pharmacokinetics of Efavirenz in Pregnancy and Postpartum with and Without First-line Tuberculosis Drugs: Results from IMPAACT P1026s

Efavirenz (EFV) pharmacokinetics (PK) may be influenced by both pregnancy-related physiological changes and concurrent treatment for drug-sensitive tuberculosis (DS-TB), and intensive 24-h EFV PK data during rifampin (RIF)/ isoniazid (INH) treatment in pregnant women living with...

Cost-effectiveness and budget impact of Luspatercept in Thai adults with transfusion-dependent beta-thalassaemia: a multi-state Markov model based on national claims data

Background Luspatercept is a first-in-class erythroid maturation agent that reduces transfusion burden in adults with transfusion-dependent beta-thalassaemia (TDT). However, its cost-effectiveness has not been evaluated in middle-income settings. This study aimed to evaluate the...

Temperature-Dependent Changes in Physicochemical Properties and Selected Bioactive Compounds During Controlled Fermentation of Cocoa Beans (Theobroma cacao)

Cocoa bean (Theobroma cacao L.) fermentation is an important postharvest process that influences the physicochemical characteristics and quality of cocoa beans. This study investigated the effects of controlled fermentation temperatures (15, 25, 35, and 45 °C) on physicochemical...

Bacterial Degradation of Persistent Organic Pollutants: From Molecular Mechanisms to Synthetic Biology

ABSTRACT Persistent organic pollutants (POPs) are among the most recalcitrant environmental contaminants due to their chemical stability, hydrophobicity, toxicity, and capacity for long‐range transport, yet mechanistic understanding remains fragmented across molecular, cellular,...

Natural regeneration and successional development of lower montane forests in northern Thailand: Decadal patterns of structural, compositional, and demographic change

Long-term evidence of structural, compositional, and demographic change during natural regeneration of tropical montane forests is limited in Southeast Asia. We analyzed six censuses (2011–2021) in two 1-ha naturally regenerating lower-montane forest stands in northern Thailand....

Nitrogen form regulates source-sink dynamics, flowering performance, and tuber development in container-grown Jerusalem artichoke revealed by 15N tracing

Optimizing nitrogen (N) form is essential for improving the ornamental quality, tuber yield, and N use efficiency of Jerusalem artichoke ( Helianthus tuberosus L.; JA). This study investigated the effects of different N forms on growth, flowering, photosystem II efficiency, tuber...

Immunomodulatory Potential of KSTM in Activating Natural Killer Cells for Cancer Cell Elimination

Background/Objectives: Cancer remains a major cause of mortality worldwide, and resistance to therapy continues to limit treatment success. Improving the susceptibility of cancer cells to immune-mediated killing, particularly by natural killer (NK) cells, may enhance therapeutic...

Thermal performance enhancement of a flat-plate solar water heater using closed-loop pulsating heat pipes as fins

Flat-plate solar water heaters (FPSHs) offer a compact and cost-effective solution for domestic water heating; however, their limited thermal efficiency restricts their energy utilization. To address this limitation, this study proposes a retrofit approach using mathematically op...

Flexible Edible Materials from Extrusion-Plasticized Modified Cassava Starches with Maltol and Ethyl Maltol: Molecular Interactions, Mechanical Properties, and Antioxidant and Antimicrobial Activities

This study systematically investigated how cassava starch modification chemistry and hydroxypropyl substitution level influence the structure and functional performance of extrusion-plasticized edible materials containing maltol or ethyl maltol. Native starch, acetylated starch,...

Global Paid and Unpaid Productivity Losses Due to Gastrointestinal Cancer Mortality

OBJECTIVES: Gastrointestinal (GI) cancers contribute substantially to premature mortality, yet their full economic burden, including unpaid work, remains underquantified. We aimed to estimate global productivity losses attributable to GI cancer mortality, considering paid and unp...