Changhai Hospital

A renal cyst-clear cell renal cell carcinoma comorbidity analysis identifies a FOXM1-positive epithelial COL6A1-CD44 axis that remodels fibroblasts

Background Renal cystic conditions are heterogeneous. We used a broad renal cyst-associated disease-gene framework to identify molecular programs shared with clear cell renal cell carcinoma (ccRCC), without modeling a specific cystic disorder or direct cyst-to-cancer progression....

Circulating and tumor microenvironment immunomarkers associate with immunotherapy efficacy in advanced bladder urothelial carcinoma: an exploratory multicenter study integrating genomic and immunophenotypic profiling

Aims To elucidate the efficacy-predictive values of immunomarkers in both peripheral blood and tumor tissue in patients with advanced bladder-urothelial-carcinoma (aBUC) undergoing first-line immunotherapy.Patients and methods In previously untreated aBUC, T-cell subclusters and...

Bile acid signaling in health and disease

Abstract Bile acids (BAs), cholesterol-derived amphipathic metabolites which are traditionally regarded as digestive surfactants, are now recognized as pleiotropic signaling molecules that act through ligand-, receptor-, and tissue-specific mechanisms to maintain systemic homeost...

Integrated single-cell and spatial transcriptomic analysis characterizes a TNBC-enriched EP5-associated malignant epithelial program and prioritizes REEP4 in breast cancer

Triple-negative breast cancer (TNBC) exhibits pronounced epithelial-state plasticity, aggressive clinical behavior, and heterogeneous responses to immune checkpoint blockade (ICB)-based neoadjuvant therapy. Bulk transcriptomic analyses cannot resolve epithelial-state heterogeneit...

Mechanical Programming of Hollow DNA Nanocapsules Rewires In Vivo Trafficking

ABSTRACT DNA nanostructures are programmable, biocompatible platforms for biomedicine; however, their mechanical properties are coupled to sequence and structural dimensions, limiting control over stiffness. Here, we report a paradigm shift from static design to mechanical engine...

Mechanical Programming of Hollow DNA Nanocapsules Rewires In Vivo Trafficking

ABSTRACT DNA nanostructures are programmable, biocompatible platforms for biomedicine; however, their mechanical properties are coupled to sequence and structural dimensions, limiting control over stiffness. Here, we report a paradigm shift from static design to mechanical engine...

Balloon guide catheter outcomes by occlusion site in the randomized PROTECT-MT trial

Background Balloon guide catheters (BGCs) are used during endovascular thrombectomy, but whether their effect varies by occlusion site is uncertain. We evaluated effect modification by baseline occlusion site in the PROTECT-MT trial. Methods This exploratory secondary analysis of...

Infrapopliteal runoff status predicts mid-term outcomes after endovascular popliteal artery aneurysm repair

This study aimed to evaluate mid-term outcomes after endovascular repair (EPAR) for popliteal artery aneurysms (PAAs), with a specific focus on identifying prognostic factors for adverse events after EPAR, particularly the impact of infrapopliteal runoff status. Open surgical rep...

Hepatitis B virus pregenomic RNA is associated with malignant phenotypes and postoperative survival in HBV-related intrahepatic cholangiocarcinoma

Abstract Background Chronic hepatitis B virus (HBV) infection contributes to infection-associated liver carcinogenesis. However, the biological and clinical relevance of HBV pregenomic RNA (pgRNA), a marker of residual viral transcriptional activity, in HBV-related intrahepatic c...

A Manganese-Chlorella Hydrogel for an Integrated “Remove–Remodel–Repair” Strategy in Pancreatic Cancer Therapy

Abstract Pancreatic cancer faces the challenges of tumor progression and postoperative pancreatic fistula during the perioperative period, which severely affect patient prognosis. In this study, an injectable self-healing multifunctional hydrogel (CMCGel) was developed based on d...

The impact of intraoperative small intestine arrangement on postoperative intestinal function recovery in patients with laparoscopic colectomy: A single-center, double-blinded, randomized controlled trial

Abstract Background This study aimed to evaluate the effect of small intestine arrangement on the bowel function after laparoscopic colectomy. Methods A total of 160 patients were randomly divided into two groups. The control group received conventional treatment, while the exper...

An Injectable ROS‐Responsive Nanozyme Hydrogel Regulates the Uterine Microenvironment to Prevent Intrauterine Adhesions

ABSTRACT Intrauterine injury triggers a self‐reinforcing cycle of inflammation, oxidative stress, and fibrosis that culminates in intrauterine adhesions (IUA), severely impairing women's reproductive health. Current treatments, including hysteroscopic adhesiolysis combined with h...

Robotic pancreatoduodenectomy in the high-difficulty tier: a retrospective cohort stratified by PD-ROBOSCORE

As a retrospective feasibility and safety analysis, this study explores the application of robotic pancreatoduodenectomy(RPD) in patients with different PD-ROBOSCORE grades at our center, with a key focus on the safety of RPD for high-difficulty procedures. This study retrospecti...

Long survival in a TP53 germline-mutant glioblastoma with multi‑omics insights

Li-Fraumeni syndrome, caused by germline mutations in TP53 , is associated with a high lifetime risk of various malignancies, including Glioblastoma (GBM). Long-term survival in GBM is extremely rare, and the underlying biological mechanisms remain poorly understood, particularly...

Middle meningeal artery embolization for chronic subdural hematoma with wedging technique

Abstract Background Chronic subdural hematoma (CSDH) commonly recurs after burr-hole evacuation or conservative management. Middle meningeal artery embolization (MMAE) using ethylene–vinyl alcohol copolymer (Onyx) aims to devascularize the subdural membranes; however, incomplete...

DUSP4 promotes anti-tumor CD8+ T cell function and boosts CAR-T cell efficacy in mouse colorectal cancer

The activation and function of CD8+ T cells, which are central for anti-tumor immunity, are tightly regulated by extracellular and intracellular signaling pathways. Dual-specificity phosphatases (DUSP), including DUSP4, dephosphorylate serine/threonine and tyrosine residues of pr...

A Non-Invasive Transtympanic Bioadhesive Hydrogel for Sustained Delivery of Dexamethasone in Otitis Media Effusion Therapy

Abstract Otitis media with effusion (OME) is a highly prevalent condition characterized by persistent inflammatory effusion in the middle ear cavity. The clinical management of OME remains challenging due to the anatomical inaccessibility of the middle ear, which limits drug effi...

A pilot prospective study of tislelizumab and axitinib combined with stereotactic body radiation therapy for oligometastatic renal cell carcinoma

<title>Abstract</title> Background The aim of this study is to investigate the efficacy and safety of tislelizumab and axitinib combined with SBRT in the treatment of omRCC. Methods Eligible pts had oligometastases (≤ 5 leisions) and ≤ 1 prior systemic therapy. All patients recei...

Endoscopic Intervention and Surgical Treatment of Benign Biliary‐Enteric Anastomotic Stricture: Real‐World Clinical Impact

OBJECTIVES: Although endoscopic interventions and surgery are both used for treating bening biliary-enteric anastomotic stricture (BEAS), their comparative efficacy, safety, and economic impact have not been established. We conducted this study to address that gap. METHODS: Patie...

Reliability and validity of the modified chinese version of new Cleveland clinic colorectal cancer quality of life questionnaire

The New Cleveland Clinic Colorectal Cancer Quality of Life Questionnaire (CCF-CaQL) was developed to assess postoperative quality of life (QoL) in patients with colorectal cancer (CRC). Since its introduction, it has been validated in several countries. This study aimed to evalua...