Chang Gung University

Eco-responsive CeCo-MOF/g-C3N4 heterointerfaces for electrochemical detection of nilutamide in aquatic systems

The widespread occurrence of pharmaceutical contaminants in aquatic environments necessitates the development of sensitive and sustainable sensing platforms for environmental monitoring. In this work, a bimetallic cerium‑cobalt metal-organic framework (CeCo-MOF) integrated with t...

Endoscopic-assisted percutaneous reconstruction of chronic Achilles tendon ruptures with allograft Achilles tendon: a report of two cases with novel surgical technique

Chronic Achilles tendon ruptures with large defects are difficult to reconstruct because of tendon retraction, poor tissue quality, and the risk of wound complications associated with open surgery. This report describes a novel endoscopic-assisted percutaneous technique for Achil...

Interfacial engineering of HA-coated PEEK through microstructure control and sulfonate functionalization for improved cytocompatibility and antibacterial activity

Background The development of multifunctional biomaterial surfaces that simultaneously support bone-cell responses and reduce bacterial infection is important for orthopedic implants. However, polymer-based polyetheretherketone (PEEK) material exhibits limited surface bioactivity...

Combined Mesenchymal Stem Cells and Low-Energy Shock Wave Therapy Significantly Reduced Inflammation, Oxidative Stress and Preserved Podocytes in Diabetic Nephropathy

Diabetic nephropathy (DN) is among the leading microvascular complications of diabetes mellitus and a major cause of end-stage renal disease. Current treatments slow disease progression but do not restore lost podocytes. We tested whether Wharton’s jelly-derived mesenchymal stem...

Campylobacter jejuni genotoxin promotes intestinal inflammation via the DNA damage-cGAS-STING signaling axis

The foodborne agent Campylobacter jejuni is a pervasive zoonotic pathogen and a major cause of gastrointestinal disease associated with inflammatory disorders in humans. While its genotoxin, cytolethal distending toxin (CDT), induces DNA damage, the toxicological signaling events...

Some Speech Codecs Hide Voice Pathology from a Fixed Detector: Directional Fidelity Readouts for Remote Voice Assessment

This manuscript is a non-peer-reviewed preprint.

Adverse pregnancy outcomes in women with atopic dermatitis: A systematic review and meta‐analysis

Abstract Background The impact of atopic dermatitis (AD) on pregnancy outcomes has been largely uncertain, and clarifying this association is essential for improving maternal counselling, risk stratification and clinical management. Objectives To assess the association between AD...

Tinea capitis in children in Northern Taiwan: An update from 2020 to 2024

Abstract Background: Tinea capitis is the most common fungal infection in children. The prevalent pathogen differs by region and shifts over time. Objectives: To investigate the current epidemiological, clinical, and mycological characteristics of tinea capitis in children in nor...

Preoperative CT-measured lateral widening is an independent associated factor with CT-detected cruciate ligament avulsion in tibial plateau fractures

To identify radiographic and computed tomography (CT) parameters predictive of cruciate ligament avulsion fractures in patients with tibial plateau fractures (TPFs). We retrospectively analyzed 127 patients with TPFs, categorized by the presence ( n = 39) or absence ( n = 88) of...

Machine Learning Model for Predicting Hepatocellular Carcinoma Development in Patients With Hepatitis B Virus‐Related Cirrhosis Receiving Antiviral Therapy

Few prediction models have been specifically designed to evaluate the risk of hepatocellular carcinoma (HCC) in patients with chronic hepatitis B and cirrhosis. This study aimed to develop a machine learning-based prediction model to assess the risk of developing HCC in patients...

Reproducibility, Replicability, and Research Quality in Homogeneous Catalysis

Abstract Researchers from all sectors of homogeneous catalysis convened in response to concerns regarding reproducibility in science to analyze the issue and provide recommendations. In addition to an in-person workshop, the group engaged the broader homogeneous catalysis communi...

Transcriptional analysis of co-stimulatory molecules in ankylosing spondylitis

Ankylosing spondylitis (AS) is a chronic inflammatory autoimmune disease where T-cell dysregulation plays a pivotal role. A balance of co-stimulatory and co-inhibitory molecules governs the activation of T cells. This study aimed to investigate the mRNA expression profiles of the...

This is Your Thyroid on Drugs: Targetable Mutations and Fusions in Thyroid Carcinoma.

This review aims to provide an overview of the molecular pathogenesis thyroid carcinomas, emphasizing genetic alterations that are therapeutically actionable. The main pathways in thyroid carcinogenesis are the MAPK and PI3K pathways. Point mutations and gene rearrangements affec...

Association of low calf circumference and underweight with sarcopenia in older adults with chronic kidney disease: a cross-sectional study

Objectives This community-based, cross-sectional study aimed to evaluate the association of calf circumference and body mass index (BMI) with sarcopenia in older adults with chronic kidney disease (CKD).Methods: Community-dwelling adults aged ≥60 years were enrolled in New Taipei...

Haptoglobin is associated with nocturnal blood pressure non-dipping in children with chronic kidney disease

Abstract Background Blood pressure (BP) follows a circadian rhythm that depends partly on endothelial nitric oxide (NO) bioavailability. Cell-free hemoglobin rapidly scavenges NO, and haptoglobin functions as a capacity-limited plasma buffer facilitating hemoglobin clearance. Whe...

Proximal Policy Optimization for Latency-Aware Service Function Chain Placement in Edge-Enabled Networks

Modern networked systems are progressively adopting network virtualization and Service Function Chaining (SFC) to deliver scalable, flexible and low-latency services. A central challenge in this context is the Service Function Chain Placement Problem (SFC-PP), which involves effi...

Targeting AHNAK ameliorates osteonecrosis of the femoral head and affects adipogenic pathways involving Smad/PPARγ

Aims This study aimed to investigate the role of AHNAK in patients with osteonecrosis of the femoral head (ONFH) and its association with bone adipogenesis. Non-traumatic ONFH, primarily driven by steroid use and alcohol consumption, results in an imbalance between osteogenesis a...

Optimizing Field-of-View for Type-1 Retinopathy of Prematurity via Multiple Instance Learning

Purpose: The purpose of this study was to cut down on screening time and costs, this study optimizes field-of-view (FOV) combinations for classifying type-1 retinopathy of prematurity (ROP) through multiple-instance learning (MIL) that models clinical decision making. Methods: Th...

Negative Pressure Promotes G3BP1-Mediated Migration of Corneal Epithelial Cells Through Activation of AKT/ERK/Paxillin Pathway

The corneal epithelium serves as the outermost transparent barrier of the eye and depends on rapid and coordinated cellular responses for wound repair. Although negative pressure (NP) has been shown to accelerate wound healing in other tissues, its cellular and molecular effects...

Development ofa Shapley Additive Explanations (SHAP)-InterpretableModel for Cardiovascular Risk Stratification in Type 2 Diabetes Mellitus:Implications of MDA-Modified Protein Adducts and Autoantibodies

Abstract Coronary artery disease (CAD) is the leading cause of mortality in type 2 diabetes mellitus (T2DM). This study explores the two-hit oxidative–immune hypothesis by evaluating malondialdehyde (MDA)-modified protein (MDA-protein) adducts and their corresponding autoantibodi...