Chang Gung University

Haptoglobin is associated with nocturnal blood pressure non-dipping in children with chronic kidney disease

Abstract Background Blood pressure (BP) follows a circadian rhythm that depends partly on endothelial nitric oxide (NO) bioavailability. Cell-free hemoglobin rapidly scavenges NO, and haptoglobin functions as a capacity-limited plasma buffer facilitating hemoglobin clearance. Whe...

Proximal Policy Optimization for Latency-Aware Service Function Chain Placement in Edge-Enabled Networks

Modern networked systems are progressively adopting network virtualization and Service Function Chaining (SFC) to deliver scalable, flexible and low-latency services. A central challenge in this context is the Service Function Chain Placement Problem (SFC-PP), which involves effi...

Targeting AHNAK ameliorates osteonecrosis of the femoral head and affects adipogenic pathways involving Smad/PPARγ

Aims This study aimed to investigate the role of AHNAK in patients with osteonecrosis of the femoral head (ONFH) and its association with bone adipogenesis. Non-traumatic ONFH, primarily driven by steroid use and alcohol consumption, results in an imbalance between osteogenesis a...

Optimizing Field-of-View for Type-1 Retinopathy of Prematurity via Multiple Instance Learning

Purpose: The purpose of this study was to cut down on screening time and costs, this study optimizes field-of-view (FOV) combinations for classifying type-1 retinopathy of prematurity (ROP) through multiple-instance learning (MIL) that models clinical decision making. Methods: Th...

Negative Pressure Promotes G3BP1-Mediated Migration of Corneal Epithelial Cells Through Activation of AKT/ERK/Paxillin Pathway

The corneal epithelium serves as the outermost transparent barrier of the eye and depends on rapid and coordinated cellular responses for wound repair. Although negative pressure (NP) has been shown to accelerate wound healing in other tissues, its cellular and molecular effects...

Development ofa Shapley Additive Explanations (SHAP)-InterpretableModel for Cardiovascular Risk Stratification in Type 2 Diabetes Mellitus:Implications of MDA-Modified Protein Adducts and Autoantibodies

Abstract Coronary artery disease (CAD) is the leading cause of mortality in type 2 diabetes mellitus (T2DM). This study explores the two-hit oxidative–immune hypothesis by evaluating malondialdehyde (MDA)-modified protein (MDA-protein) adducts and their corresponding autoantibodi...

Tumor-derived RPS19 engages C5AR1+ inflammatory macrophages to drive astrocyte reprogramming and glioblastoma progression

Glioblastoma (GBM) is an incurable brain tumor with poor survival outcomes. Its progression and recurrence are strongly influenced by infiltrative growth of tumor cells and tumor microenvironment (TME) components, particularly tumor-associated macrophages (TAMs). To identify pote...

Tailoring Trilayer LiTa 2 PO 8 ‐Based Hybrid Solid Electrolytes to Enhance Interfacial Compatibility and Efficient Lithium Transport in Lithium Metal Batteries

ABSTRACT Herein, a spatially decoupled trilayer hybrid solid electrolyte (THSE) is designed through functional architecture engineering to simultaneously optimize ionic conduction and interfacial stability. THSE integrates a polymer matrix comprising a Li + ‐conductive LiTa 2 PO...

Same-day EHR-coded sevoflurane versus propofol exposure and long-term coded dementia in older surgical adults: a propensity-matched cohort study

Whether perioperative EHR records of sevoflurane and propofol identify clinically meaningful differences in long-term dementia risk is uncertain. We compared same-day EHR-coded sevoflurane versus propofol exposure in relation to subsequent coded dementia among older adults underg...

Anakinra in Severe RSV-Associated Autoinflammatory Encephalopathy With Delayed ADEM-Like Changes

Respiratory syncytial virus (RSV)-associated encephalopathy is an uncommon but potentially devastating complication in children. Increasing evidence suggests that infection-triggered neuroinflammation rather than direct viral invasion underlies neurologic injury in a subset of pa...

Prognostic Accuracy of the Phoenix Sepsis Criteria for Mortality in Children With Suspected Infection: A Systematic Review and Meta-Analysis

Objectives: We aimed to evaluate the pooled prognostic accuracy of the Phoenix Sepsis Criteria (PSC) for in-hospital mortality and compare its performance with the International Pediatric Sepsis Consensus Conference (IPSCC) criteria in children with suspected infection. Data Sour...

Interpersonal Predictors of Youth Internalizing Symptom Trajectories During the COVID‐19 Pandemic

INTRODUCTION: The COVID-19 pandemic disrupted youths' interpersonal relationships, posing risks for internalizing distress. Yet, evidence remains limited beyond the early pandemic waves and with changing interpersonal contexts. This study examined trajectories of youth internaliz...

Neurocognitive Functions and Their Associations With Autistic Symptoms, Emotion, and Behavior in High-Functioning Children and Adolescents With Autism Spectrum Disorder

Objective Studies have revealed the prognostic significance of intelligence in children with autism spectrum disorder (ASD), but the correlations of non-social cognitive functions and clinical characteristics of high-functioning children and adolescents with ASD remain unclear. T...

Fracture morphology guides the selection of closed versus open reduction in straddle fractures: outcomes of an indication-based treatment strategy

To identify fracture characteristics associated with the selection of closed reduction (CR) or open reduction (OR) for anterior pelvic ring fixation in patients with straddle fractures and to evaluate the radiographic, functional, and complication outcomes following an indication...