Centro Nacional de Biotecnología

Structure–Redox–Magnetism Dynamics Induced by Pd–Fe Interaction in Mixed Iron Oxide Nanoparticles

Abstract The incorporation of noble metals into iron oxide nanomaterials represents an effective strategy to tailor their redox and structural properties through metal-oxide interactions. However, a detailed experimental understanding of these effects is limited. This work invest...

Toward Iron-Biofortified Rice: Integrating BRUTUS-Family Regulation and Iron Chaperone Biology

Abstract Rice is both a leading model for cereal molecular genetics and one of the world’s most important staple foods, which makes it a decisive crop for iron (Fe) biofortification. However, the breeding goal is not simply to increase total plant Fe or even total grain Fe. For p...

Decoding the Cellular Response to Methylthioadenosine Uncovers Novel Targets for Chronic Liver Disease

Progressive familial intrahepatic cholestasis type 3 (PFIC3), caused by MDR3 deficiency (MDR2 in mice), is a lethal pediatric liver disease characterized by early-onset persistent cholestasis, progressive fibrosis, cirrhosis, and eventual liver failure. MDR3 is a phosphatidylchol...

Structural and single-molecule insights into the core human mitochondrial DNA replisome.

Replication of human mitochondrial DNA (mtDNA) is essential for the maintenance of oxidative phosphorylation and cellular energy homeostasis. Impairment of this process leads to mtDNA deletions, depletion, and point mutations that underlie a broad spectrum of mitochondrial diseas...

Phagocytosis of microbial symbionts supports embryonic nutrition in the sponge Halichondria panicea

Abstract Animals associate with microbial symbionts that play crucial roles in their nutrition and development, yet their function during gametogenesis and embryogenesis remains poorly understood. Here, we investigate host–symbiont dynamics throughout the reproductive cycle of th...

Adaptation to seasonal drought in Arabis alpina is linked to the demographic history and climatic changes since the last glacial maximum

Abstract Understanding how species adapt to new environments is a central goal in evolutionary biology, and a topical question in climate change research. Here, we sequenced the genomes of 426 individuals of the perennial, Arctic-alpine herb Arabis alpina to study demography and...

Viral transport in evaporating sessile model respiratory droplets

Abstract Viral particles, or virions, may remain infectious in the dry residue of respiratory droplets for times as long as hours. This is counterintuitive, since salt concentration increases dramatically as the drop's water evaporates, making the drop a harsh environment for vir...

Adaptive thermogenesis and fermentation as survival strategies of vegetative cells of Bacillus subtilis under simulated Martian stressors

<title>Abstract</title> Microbial responses to Mars‑analog environments are key to understanding the limits of life and improving life‑detection strategies. Here, we investigated the survival and physiological adaptation of <italic>Bacillus subtilis</italic> exposed for five sols...

Engineered microorganisms for environmental release: current situation and future perspectives

Engineered microorganisms for environmental release (EMERs) hold a considerable potential for bioremediation of sites polluted with urban and industrial emissions. The growing availability of EMERs with phenotypes that can help recovering polluted sites and degraded ecosystems co...