Centro de Investigación y de Estudios Avanzados del Instituto Politécnico Nacional

Potentially Toxic Elements in Urban Dust of Tlaxcala, Mexico: Pollution Levels and Human and Ecological Risk Assessment

The city of Tlaxcala, located in central Mexico, is a small region with high industrial activity that releases potentially toxic elements (PTEs) into the environment. This study investigated the concentration, distribution, contamination levels, and human and ecological health ri...

Phytotoxicity and Data Analytics Pipeline for Silver-Coated Cobalt Ferrite Nanoparticles (Ag@CoFe2O4 NPs) in Wheat Plants

This notebook implements an advanced ecotoxicological data analytics pipeline to evaluate the phytotoxicity and multivariate physiological impacts of silver-coated cobalt ferrite nanoparticles (Ag@CoFe2O4 NPs) in wheat plants. Organized into four analytical stages, the workflow h...

Efficient Spiking Neural Network Prototype on FPGA for Classifying Gases

Spiking neural networks (SNNs) are numerical models whose computational properties come from interconnected biological neurons and synapses, leading to the development of neuromorphic systems in either software or hardware. These models in digital hardware operate in the discrete...

Pharmacological Analysis of P2Y Purinergic Receptors That Modulate the Rat Vasopressor Sympathetic Tone

Background/Objectives: Adenosine 5′-O-(β-thio)-diphosphate (ADPβS) is a stable analogue of adenosine diphosphate (ADP). In pithed rats, ADPβS produces (i) inhibition of both the cardioaccelerator sympathetic tone (via prejunctional P2Y12/P2Y13 receptors) and the vasodepressor sen...

Message in a bottleneck: Nested founder effects from French Polynesia to Rapa Nui and Hawaiʻi

Founder effects can lead to strong, population-specific allele frequency differentiation, including autosomal recessive conditions. Their characterization in European-descent groups, such as the Finnish and Amish, has resulted in actionable genetic tests for each. We show that Po...

Development and Characterization of Bioactive Sodium Alginate Dressings Incorporating Melipona beecheii Honey for Wound Healing Applications

Healing wounds and skin lesions has been practiced since ancient times, and various mechanisms have been used to treat them, ranging from bandages and herbs to ointments and modern alternatives such as dressings. This work aimed to develop bioactive dressings for wound healing. D...

Block method: Reference-anchored peak fitting for tracking subtle chemical evolution in sequential XPS spectra

The Block Method is a refinement of spectral subtraction developed for the analysis of complex x-ray photoelectron spectroscopy data. In this method, the fitted spectrum of a reference sample is converted into a structured spectral block and used as an additional component during...

Determination of the metric of a Schwarzschild black hole surrounded by a halo of dark matter

Abstract Following the landmark acquisition of the first image of a black hole, systems comprising a black hole enveloped by a dark matter halo have attracted considerable attention. This work implements a novel method to analyze the structure of a system composed of a Schwarzsch...

Enhancing motor prosthesis training through a gamified mixed-reality system

Abstract During the advanced stages of hand prosthesis training, amputees strive to perfect their movements to enhance fine motor skills, increase speed, and achieve fluid and continuous actions. However, this training typically occurs in abstract, low-engagement scenarios, limit...

Anatomical Asymmetry in Adipose Tissue Thickness Alters Heat Transfer During Superficial Thermotherapy: A Computational and Experimental Study

Computer models and protocols commonly used for superficial thermotherapy assume anatomically symmetric tissue geometries. However, anatomical variability, particularly the variability of the adipose tissue thickness, may have a significant impact on heat transfer and cause non-u...

Polyethylene Glycol Architecture Governs Interfacial Thermodynamics and Drug Adsorption in Anionic Lipid Microbubbles

Abstract Polyethylene glycol (PEG)-stabilized lipid microbubbles (MBs) are promising ultrasound-responsive drug delivery platforms; however, their optimization remains largely empirical and fails to resolve the interfacial mechanisms governing drug adsorption and stability. Here,...

The distribution of fitness effects of nonsynonymous mutations varies phylogenetically across animals

The distribution of fitness effects (DFE) describes the selection coefficients of newly arising mutations and fundamentally influences population genetic processes. However, the extent and mechanisms of differences in the DFE for non-synonymous mutations have not been systematica...

The highly heterozygous European amphioxus (Branchiostoma lanceolatum) at the edge of panmixia

Abstract Amphioxus (Cephalochordata) are small marine chordates that have broad ecological ranges, yet as adults form local settlements and exhibit limited mobility. Genomic surveys of two amphioxus species have suggested that they rank among the most genetically diverse metazoan...

Design, synthesis, drug-likeness, and molecular dynamics evaluations of monobrominated amathamide G analogs as potential ligands for D2-like dopamine receptors

Abstract Dopamine receptors (DRs) are key modulators of physiological and behavioral responses in the central nervous system (CNS), playing a major role in psychotic disorders. Among these, the D2-like members D2R, D3R and D4R are particularly attractive therapeutic targets for t...

Exact rotating dilatonic branch in ModMax electrodynamics without Maxwell analogue

Abstract We present a novel class of rotating dilatonic solutions within the framework of Einstein–ModMax-type gravity. The configuration belongs to the nonlinear sector characterized by $$\mathcal F/\mathcal G=\textrm{const}$$ F / G = const and carries nontrivial electric and ma...

Early-life overconsumption of a high-carbohydrate diet induces metaflammation and kidney injury without impairment of function in adult Wistar rats

Abstract Frequent consumption of sugary and calorie-dense foods and beverages during childhood may contribute to the development of metabolic syndrome (MetS) in adulthood, a risk that can manifest independently of overweight status. Metaflammation, a low-grade inflammation associ...

Climate Change Impacts on One Health Systems: A Narrative Review of Empirical Evidence and Policy Responses

ABSTRACT Background Climate change poses critical threats to human, animal, and environmental health, yet evidence on integrated One Health responses remains fragmented. Although numerous studies highlight climate‐driven health risks, many climate adaptation frameworks still unde...

Magnetic Nanoparticle-Assisted Immobilized Co-Culture of Saccharomyces cerevisiae and Kluyveromyces marxianus: Effects on Ethanol Production, Sugar Consumption, Biomass Reuse, and Volatile Metabolite Profiles

Yeast-assisted mixed-culture fermentations have gained attention for their ability to enhance fermentation efficiency and modulate metabolite production. There is little knowledge on the impact of magnetic nanoparticle-assisted immobilization on yeast–yeast interactions during al...

Relative gain array–based interaction modification via compensator design: experimental validation on a 2-DOF helicopter

This paper proposes a compensator design methodology based on the Relative Gain Array (RGA) for systematically modifying the steady-state interaction structure of linear multivariable systems. Unlike the conventional use of the RGA as an analysis tool for input–output pairing sel...

Signature invariants of monomial ideals

Abstract Let I be a monomial ideal of a polynomial ring $$R=K[x_1,\ldots ,x_n]$$ <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"> <mml:mrow> <mml:mi>R</mml:mi> <mml:mo>=</mml:mo> <mml:mi>K</mml:mi> <mml:mo>[</mml:mo> <mml:msub> <mml:mi>x</mml:mi> <mml:mn>1</mml:mn> </mml...