Centre Hospitalier Universitaire de Montpellier

Can machine learning be used to quantify blood loss based on hemodynamic data? Experimental study of controlled hemorrhagic shock in anesthetized piglets

Background Hemorrhagic compensatory physiological mechanisms may initially lead to an underestimation of the severity of a hemorrhage, for which quantification of blood lost volume is difficult. The objective of our study was to assess the suitability of machine learning (ML) to...

Intermittent or Continuous Renal-Replacement Therapy in Acute Kidney Injury

BackgroundThe preferred method of renal-replacement therapy for acute kidney injury in critically ill patients remains uncertain. MethodsIn this multicenter, open-label, noninferiority trial, we randomly assigned critically ill adults with acute kidney injury who had indications...

Guidelines for Decisions to Withhold or Withdraw Life-Sustaining Treatments (LST) in Adult ICU

OBJECTIVE: The French Society of Anaesthesia and Intensive Care Medicine (Société française d'anesthésie et de réanimation, SFAR) and the French Society of Physical Medicine and Rehabilitation (Société Française de Médecine Physique et de Réadaptation (SOFMER)) aimed at providing...

Cerebral No‐Reflow after Thrombectomy: International Delphi Consensus on Definition and Imaging Assessment

BACKGROUND: The operational definition and imaging assessment of the no-reflow phenomenon, a potential contributor to poor clinical outcome despite successful thrombectomy, remains debated. We aimed to develop expert-based international consensus on the definition, assessment, an...

Association between the site of emergency care and patient-centered outcomes in patients with cancer: rationale and design of the French COVER cohort

Patients living with cancer now account for a substantial and growing share of emergency department (ED) visits and carry a high burden of hospitalization and in-hospital death. Their acute presentations are frequently multifactorial - driven by disease progression, treatment tox...

Contraceptive use in women of childbearing age with bipolar disorder

INTRODUCTION: Unplanned pregnancies are frequent in women with bipolar disorder (BD) while perinatal period is associated with a higher risk of relapse. Effective contraception during childbearing age in BD could reduce the risk of unplanned pregnancy and its consequences. The pr...

Few-shot learning for expert consensus severity stratification in newly diagnosed crohn’s disease

Early and accurate assessment of disease severity is important for standardizing baseline risk stratification and supporting treatment planning in newly diagnosed Crohn’s disease. This study used electronic medical record data, a few-shot learning algorithm, and SHAP-based interp...

Post-Nap Sleep Inertia in Narcolepsy Type 1 and Idiopathic Hypersomnia

Abstract Study objectives To compare post-nap sleep inertia between patients with idiopathic hypersomnia (IH) and narcolepsy type 1 (NT1) by assessing changes in subjective sleepiness and objective performance. Methods In 128 drug-free patients (50 IH, 78 NT1), standardized overn...

Beyond correlation: Intraclass correlation and bland-altman analysis reveal poor absolute agreement across multiplex cytokine immunoassay platforms

Cross-platform comparisons of serum cytokine immunoassays have often focused on rank correlation, but the extent of absolute agreement and systematic bias between platforms remains insufficiently characterized. Few independent head-to-head evaluations have compared multiple immun...

Factors associated with progression from level 1 to level 2 sensor‐detected hypoglycaemia in people with type 1 and insulin‐treated type 2 diabetes: a post hoc analysis from the Hypo‐METRIC Study

Aims We investigated the proportion of sensor-detected hypoglycaemic (SDH) events progressing to level 2, and associated variables. Materials and Methods We used data from Hypo-METRICS, which recruited people with type 1 (pwT1D) and insulin-treated type 2 diabetes (pwT2D) with ≥...

Immune‐related adverse events with mogamulizumab in cutaneous T‐cell lymphoma: A multicentre study

BACKGROUND: Mogamulizumab, an anti-CCR4 monoclonal antibody used in advanced mycosis fungoides (MF) and Sezary syndrome (SS), also depletes regulatory T cells, potentially leading to immune-related adverse events (irAEs). Unlike mogamulizumab-associated rash (MAR), other irAEs re...

Standards for practical management of drug hypersensitivity reactions to intravenous drugs and proactive early allergy involvement before referral: A WAO Statement

Hypersensitivity reactions to intravenous therapies—including antibiotics, chemotherapeutics, biologics, anesthesia agents, and contrast media—pose significant challenges in acute care settings. These reactions often occur outside the purview of allergy specialists, leading to de...

Serum GFAP and Age Accurately Distinguish AQP4 ‐ IgG Positive and Double Seronegative NMOSD From MOGAD After a Recent Attack

BACKGROUND: Serum neurofilament-light chain (sNfL) and glial fibrillary acidic protein (sGFAP) are associated with multiple sclerosis (MS) activity. This study aimed to identify patient- and disease-level determinants of sNfL and sGFAP and to evaluate their ability to support dif...

The future of allergy and immunology care: A perspective on innovation, equity, and global collaboration from the WAO Junior Members Group

Allergic and immunological diseases are among the fastest-growing non-communicable conditions worldwide, affecting all age groups and regions.1 The increasing burden of asthma, allergic rhinitis, atopic dermatitis, food allergy, and other immune-mediated conditions is driven by c...

Mechanical Thrombectomy Versus Medical Management for Large Ischemic Core Stroke Identified before Inter‐Hospital Transfer: A Post Hoc Analysis of the LASTE Trial

Objective This study assessed the efficacy of thrombectomy in acute ischemic stroke because of large‐vessel occlusion (AIS‐LVO) initially admitted to primary stroke centers (PSC) and subsequently transferred to a comprehensive stroke center (CSC), with a large ischemic core ident...

Low intensity transcranial electrical stimulation for schizophrenia: a triple-blind, randomized, sham-controlled multicenter trial (STIM’Zo)

Persistent symptoms in schizophrenia remain a major therapeutic challenge. Noninvasive electrical stimulation such as transcranial random noise stimulation (tRNS) may alleviate auditory hallucinations and negative symptoms, although existing evidence is limited to case reports an...

Consensus Definition for Community-acquired Pneumonia in Children Using a Delphi Approach

Background: Although community-acquired pneumonia (CAP) is one of the most common infections in children, no standardized criteria for diagnosis exist. The objective of this study was to develop expert consensus for the diagnosis of pediatric CAP in countries with a high level of...

The NPIS model: a consensus-based framework for evaluating non-pharmacological interventions

The term non-pharmacological intervention (NPI) refers to health prevention and care protocols supervised by healthcare professionals. However, no precise and widely adopted definition currently exists. Additionally, unlike drugs, NPIs do not have a global evaluation framework be...

Natural product-derived compounds modulating STAT3 signaling in prostate cancer: Mechanistic insights and therapeutic potential

Prostate cancer (PCa) is a major malignancy in men and current treatment options remain limited by therapeutic resistance and treatment-related toxicity. Signal transducer and activator of transcription 3 (STAT3) is a key regulator of PCa progression and an attractive therapeutic...

Appendicular Versus Non-Appendicular Community-Acquired Intra-Abdominal Infections: A Post-Hoc Analysis of the PERICOM Multicenter Study

Background: Community-acquired intra-abdominal infections (CA-IAIs) exhibit significant clinical heterogeneity. However, most studies focusing on CA-IAIs do not stratify comparisons by infection site. Methods: This post hoc analysis of the prospective multicenter PERICOM cohort (...