Center for Systems Biology

Multimodal folate receptor-targeted liposomes enable photo-chemo-antibiotic synergy for peritoneal cancer therapy

The complex and heterogeneous nature of cancer presents significant challenges to effective treatment. Because no single therapy can overcome this complex challenge, rational combination strategies that concurrently target tumor survival pathways and engage non-overlapping mechan...

Click‐to‐Release Reactivity of Quaternary Anilinium Tetrazines Enables Cascade Assembly of Multifunctional Biomolecular Scaffolds

Click chemistry has evolved from its origins in forming covalent connections to also include breaking bonds, cleaving linkers, and liberating cargo, creating broad applications in chemical biology and biomedicine. The reaction sequences that drive these tools are complex, and thu...

An immunocompetent, multifluorescent resource for real-time analysis of osteosarcoma progression, metastasis, and response to therapy

Despite substantial treatment improvements, the 5-year survival rate for metastatic osteosarcoma (OS) is still as low as 20%. Immunocompetent genetic mouse models of OS have been introduced, enabling in vivo OS studies. Here, we present the ROCCIA mouse, a quintuple-mutant extens...

Tunable nanofluidic ion gating via in situ salt precipitation-dissolution

Nanofluidic ion gating underpins both biological signal transduction and iontronic signal processing. However, a simple and reliable mechanism that functions independently of local electrochemical conditions remains unavailable, hindering interference-free integration of artifici...

International variation in neuropsychological test use practices: Implications for test adaptation and fair assessment

Neuropsychological test selection varies substantially across countries and languages, yet which instruments clinicians use internationally remains poorly documented. Using a survey of International Neuropsychological Society members (INSConnect, 2023), we examined instrument end...

Prenatal maternal infection promotes maternal microchimeric cells to alter infection risk in male offspring

Summary Vertically transferred maternal cells or maternal microchimeric cells (MMCs) engraft the fetus and persist in offspring for long periods of time. How altered maternal immune states arising from infection affect MMCs and their function in offspring is poorly understood. He...

Multi-stage single-cell atlas of a chordate non-embryonic development unveils dedifferentiating bud founder cells

Abstract Colonial tunicates are the only chordates capable of forming fully functional bodies from somatic tissues through non-embryonic development, or budding. In Botryllus schlosseri , budding produces new individuals (zooids) from a portion of the peribranchial epithelium of...

Elevated translocator protein in skull bone marrow is linked to human chronic pain

The skull bone marrow (SBM) is emerging as a critical hub for neuroimmune signaling, yet its role in chronic pain is unknown. Using integrated positron emission tomography/magnetic resonance imaging, here, we show that the levels of 18-kilodalton translocator protein (TSPO), a pu...

Epitope-conditioned generation of T-cell receptor β-chain CDR3 candidates using a pre-trained transformer model

Prioritizing T-cell receptor (TCR) candidates for defined peptide-HLA targets is an important step in TCR-based immunotherapy development, but it still relies heavily on laborious and expensive experimental screening. Recent advancements in generative artificial intelligence have...

Reconstruction of epithelial transcriptional trajectories reveals heterogeneous progression and early therapy-resistance programs in high-grade serous carcinoma precursors

Abstract Background Serous-tubal intraepithelial-carcinoma (STIC) is considered the principal precursor of tubo-ovarian high-grade serous-carcinoma (HGSC), yet its biological uniformity, progression risk and potential response to poly(ADP-ribose) polymerase-inhibitors (PARPi) rem...

Cannabinoids suppress chemotherapy- and ionizing radiation-induced apoptosis of glioblastoma cells

Abstract Cancer patients are increasingly exposed to cannabinoids, the bioactive molecules produced by the Cannabis sativa La. plant. This trend is being driven by several factors: expanding cannabis legalization, FDA approval of select cannabinoids for the treatment of seizures...

A dependency map enhanced with next-generation 3D cancer models

Despite advances in precision oncology, effective personalized treatments are still lacking for most patients with cancer1. The Cancer Dependency Map (DepMap) accelerates this field by systematically identifying cancer vulnerabilities in diverse preclinical models. Data from over...