Center for Excellence in Brain Science and Intelligence Technology

Dendritic computation for abstract rule-based flexible decision-making

Intelligent behavior involves flexible integration of sensory input and abstract rule knowledge. Dendritic computation has been shown to contribute to top-down modulation of sensory processing; however, whether and how it is involved in flexible cognitive processing remains to be...

Postnatal sensorimotor experience causally shapes hemispheric specialization across motor and language networks

The functional organization of the human brain is shaped by the interplay between innate constraints and postnatal experience. Hemispheric specialization, as a fundamental organizing principle of brain function, raises unresolved questions about how postnatal experience shapes la...

Preparing large biological specimens for high-throughput volume electron microscopy

Abstract To enable high-throughput volume electron microscopy (vEM) imaging, osmium-based staining methods are routinely employed to enhance membrane contrast and electrical conductivity in biological specimens. Nevertheless, reliable preparation of densely and uniformly stained...

Spatial transcriptional signatures linked to brain activity patterns in MECP2 transgenic monkeys and human autism spectrum disorder

Imaging transcriptomics studies in autism spectrum disorder (ASD) have identified relevant biological pathways, yet the specific laminar molecular signatures associated with functional abnormalities remain largely unexplored. We integrated resting-state fMRI (rs-fMRI) data from m...

CDSB: accelerating connectomics workflow via Content-Decoupled Schrödinger Bridge

Abstract Background Large-scale connectomics requires the nanometer-scale resolution of electron microscopy to resolve ultrastructural details, but its acquisition is time- and labor-intensive. In contrast, high-throughput light microscopy offers high throughput but lacks the spa...

High-frequency visual stimulation can increase medial temporal lobe ripple oscillation density

Abstract Background Flickering visual stimulation can evoke neural oscillations, which can influence ongoing brain activity. Electrophysiological recordings of neural oscillations in the ripple band (80–180 Hz) show that these high-frequency oscillations occur in the neocortex an...

MedKGent: a large language model agent framework for constructing temporally evolving medical knowledge graph

The rapid expansion of medical literature challenges the scalable structuring of domain knowledge. Knowledge Graphs (KGs) offer a solution, yet current construction methods lack generalizability and ignore the temporal dynamics of evolving knowledge. To address this, we introduce...

Single-cell atlas of reproductive endocrine organs reveals transcriptomic responses to type 1 diabetes mellitus in nonhuman primates

Abstract Type 1 diabetes mellitus characterized by insulin deficiency and hyperglycemia is associated with female subfertility. However, how hyperglycemia affects the hypothalamic-pituitary-ovarian-uterine axis remains poorly understood. In this study, we performed single-cell tr...

All-Optically Controlled Memristive Reservoir Computing Capable of Bipolar and Parallel Coding

Physical reservoir computing (RC) utilizes intrinsic dynamics of physical systems for efficient data processing. Emerging optoelectronic RC platforms merge the benefits of electronic and photonic computation. However, conventional designs are constrained by the unipolar photoresp...