Center for Cancer Research

Immunohistochemistry vs Molecular Breast Cancer Subtyping Among African Populations

Importance Breast cancer subtyping based on immunohistochemistry (IHC) guides systemic therapy where gene expression profiling assays are unavailable, yet its validity against molecular reference standards remains poorly characterized in African populations, where laboratory infr...

Clinical and genetic risk factors for apolipoprotein L1-mediated chronic kidney disease in people of African ancestry with HIV

PURPOSE OF REVIEW: To summarize current understanding of the epidemiology, pathogenesis and management of HIV-Associated Nephropathy (HIVAN) and other forms of Apolipoprotein L1 (APOL1)-mediated chronic kidney disease (CKD) in people of African ancestry with HIV. RECENT FINDINGS:...

Biomarker discrepancies following chimeric antigen receptor T cells: implications in B-cell acute lymphoblastic leukemia

Not available.

Multi-Field Relaxation Dynamics of Parahydrogen-Hyperpolarized Propane Gas MRI Contrast Agent

Abstract Hyperpolarized gas-phase MRI is an emerging diagnostic modality, with the clinical utility of hyperpolarized Xe-129 gas for functional lung imaging recently supported by FDA regulatory approval. However, the requirement for dedicated multi-nuclear hardware and complex, c...

Δ133p53α, a senescence-inhibitory p53 isoform, attenuates accelerated aging in progeria mice

Abstract Research on progeria not only contributes to the development of treatments for the disease but also enhances our understanding of physiological aging. In a mouse model of Hutchinson-Gilford progeria syndrome (HGPS), transgenic expression of Δ133p53α, a senescence-inhibit...

DHODH is the key target of the KDM4 inhibitor QC6352 in glioblastoma stem cells

Abstract Histone lysine demethylase 4 (KDM4) enzymes are frequently overexpressed in cancer and are considered to be promising therapeutic targets. QC6352, which is widely used as a best-in-class KDM4 chemical probe, shows potent antitumor activity across cancer models. Using com...

Click‐to‐Release Reactivity of Quaternary Anilinium Tetrazines Enables Cascade Assembly of Multifunctional Biomolecular Scaffolds

Click chemistry has evolved from its origins in forming covalent connections to also include breaking bonds, cleaving linkers, and liberating cargo, creating broad applications in chemical biology and biomedicine. The reaction sequences that drive these tools are complex, and thu...

A randomized phase 2 placebo-controlled trial of clobetasol solution for oral chronic graft-versus-host disease therapy

Chronic graft-versus-host disease (cGVHD) affects multiple organ systems and frequently the mouth. There is an unmet need for more effective topical therapy to adequately control cGVHD in the oral cavity. Clobetasol is a super-potent synthetic glucocorticoid formulated here as an...

Positive selection screen identifies natural product β-catenin inactivators

Many genetically validated targets in cancer, including the transcription factor β-catenin (β-cat), have historically been viewed as undruggable. Cell-based phenotypic screening of chemical compounds can reveal unanticipated biological and pharmacological principles. Natural prod...

Actionable genetic landscape and dynamics in circulating DNA from 12,827 patients with metastatic breast cancer

Abstract Plasma cell-free DNA (cfDNA) is a sensitive, noninvasive tool for monitoring the genomic landscape, heterogeneity, and evolution of cancer, aggregating genetic information from multiple metastatic sites. Here, we study 15,564 cfDNA samples from 12,827 patients with metas...

RamanOmics decodes the spatial vibrational–molecular architecture of senescence in aging and repair

Aging and tissue repair involve heterogeneous remodeling across transcriptional, biochemical and cellular dimensions, yet prevailing definitions rely on isolated molecular markers that obscure how these states co-evolve. Here we present RamanOmics, a multimodal framework integrat...

Patient-Derived Transcriptomics Reveals Distinct Associated IFNγ-Myeloid States and Mitochondrial Complex I Programs in Rheumatoid Arthritis and Osteoarthritis

Background/Objectives: Macrophages are key contributors to the pathogenesis of rheumatoid arthritis (RA) and osteoarthritis (OA), but their disease-associated immunometabolic states remain incompletely understood. Methods: Here, we comparatively analyzed patient-derived transcrip...

Overcoming immune checkpoint inhibitor-mediated T-cell exhaustion with a TCR β chain-directed selective dual T-cell activator

Abstract Background Resistance to immune checkpoint inhibition (ICI) using antibodies against the PD-1/PD-L1 axis remains a significant clinical challenge. Here, we report that combination of anti-PD-1 with a bifunctional fusion molecule, anti-TCRβ-IL-2, comprised of a monovalent...

OncoRAG: graph-based retrieval enabling clinical phenotyping from oncology notes using local mid-size language models

Abstract Oncology notes contain the richest clinical detail, yet they remain largely inaccessible at scale because extracting structured phenotypes requires either substantial language model infrastructure, curated training data, or cloud computing under regulatory constraints. W...

Elacestrant in Combination with Everolimus for Estrogen Receptor-Positive, HER2-Negative Previously Treated Advanced Breast Cancer: Results from ELEVATE

PURPOSE: Treatment options for progression on first-line endocrine therapy (ET)+CDK4/6i for ER-positive/HER2-negative (ER+/HER2-) advanced breast cancer (ABC) include ET plus targeted agents (CDK4/6i or PI3K/AKT/mTOR-pathway inhibitors). Elacestrant is the first single-agent oral...

Modulatory effects of S1QEL on OxLDL-induced metabolic alterations and inflammatory responses in human monocytes

Background Oxidized low-density lipoprotein (OxLDL) plays a key role in initiating monocyte activation, glycolytic reprogramming, and pro-inflammatory cytokine production—processes that contribute to aging and progression of age-related diseases such as atherosclerosis and steato...

Synergistic lethality of combination treatment with Trop2-directed antibody-drug conjugate sacituzumab govitecan and TRAIL agonists in triple negative breast cancer

Abstract Background Sacituzumab govitecan (SG) is an antibody drug conjugate targeting trophoblast cell surface antigen 2 (Trop2) that is approved for treatment of patients with metastatic triple negative breast cancer (TNBC). Tumor necrosis factor-related apoptosis inducing liga...

Lipidomic and transcriptomic remodeling underlies early retinal pathogenesis in dry age-related macular degeneration

Abstract Dry age-related macular degeneration (AMD) is initiated by retinal pigment epithelium (RPE) dysfunction, yet early metabolic mechanisms linking RPE injury to photoreceptor dysfunction remain unclear. Using a physiologically relevant mouse model, we performed cell-type–re...

A compendium of next-generation patient-derived models for diverse cancers

Abstract The development of new therapeutics and the validation of pathogenetic cancer mechanisms require representative laboratory models 1,2 . However, existing collections represent only a fraction of the diversity observed in human cancer 2–4 . Recent technologies have enable...

Architecture-Dependent Stability, Cellular Uptake,and Redox Modulation of Poly(p-Coumaric Acid) Hybrid Nanoparticlesfor Ovarian Carcinoma Intervention

Abstract The clinical efficacy of fluorescence-guided surgery is often compromised by the poor photostability and biologically inert nature of conventional contrast agents such as Indocyanine Green (ICG). While nanocarriers can enhance dye stability, they often function primarily...