Institution
Center for Cancer Research
Recent research
- Health & MedicineOpen access
Abstract Background Sacituzumab govitecan (SG) is an antibody drug conjugate targeting trophoblast cell surface antigen 2 (Trop2) that is approved for treatment of patients with metastatic triple negative breast cancer (TNBC). Tumor necrosis factor-related apoptosis inducing liga...
- Health & MedicineOpen access
Abstract Dry age-related macular degeneration (AMD) is initiated by retinal pigment epithelium (RPE) dysfunction, yet early metabolic mechanisms linking RPE injury to photoreceptor dysfunction remain unclear. Using a physiologically relevant mouse model, we performed cell-type–re...
- Health & MedicineOpen access
Therapeutic NAMPT inhibition reveals a targetable metabolic vulnerability in neuroblastoma
Abstract Background Neuroblastoma (NB) remains a major cause of pediatric cancer mortality for which new therapeutic strategies are needed. Exploitation of reprogrammed metabolic pathways offers an opportunity for cell-type specific anticancer therapeutics. To identify pediatric...
- Engineering & Technology
Abstract The clinical efficacy of fluorescence-guided surgery is often compromised by the poor photostability and biologically inert nature of conventional contrast agents such as Indocyanine Green (ICG). While nanocarriers can enhance dye stability, they often function primarily...
- BiologyOpen access
A compendium of next-generation patient-derived models for diverse cancers
Abstract The development of new therapeutics and the validation of pathogenetic cancer mechanisms require representative laboratory models 1,2 . However, existing collections represent only a fraction of the diversity observed in human cancer 2–4 . Recent technologies have enable...