CEA Grenoble

Hackathon on predictive modelling in systems pharmacology: design, implementation, and outcomes

Background The growing availability of multi-omics data and machine learning methods creates both an opportunity and a challenge for the systems pharmacology community: the opportunity to model drug action at unprecedented mechanistic resolution, and the challenge of equipping a...

Superinfection exclusion strategy of siphophage T5: analysis of the FhuA:Llp complex

ABSTRACT Superinfection exclusion is a widespread viral mechanism that protects the infected cell from overinfection by other identical or closely related viruses. Shortly after infection by bacteriophage T5, the bacterium Escherichia coli produces Llp, encoded by the newly injec...

Domain‐Wall Circulation Gating and Pinning via Compositional Engineering of Cylindrical Nanowires

ABSTRACT Spintronic devices based on cylindrical magnetic nanowires have been proposed as a route toward three–dimensional (3D) information storage and processing by harnessing the controlled motion of domain walls (DWs). In this geometry, the Bloch‐point wall (BPW) is the charac...

Thickness-Dependent Spintronic Terahertz Emission in Molecular Beam Epitaxy-Grown PtTe2: From Semiconductor to Type-II Dirac Semimetal

Abstract Spintronic THz emitters are the most practical broadband sources, but their performance is constrained by the spin Hall conductivity of the conversion layer. We show that PtTe2, a type II Dirac semimetal, overcomes this limitation through thickness-driven electronic phas...

Targeting the Complement C1 Proteases Using Camelid-Derived Single Domain Antibodies: Production, Characterization and Possible Application for Tissue/Fluid Analysis

Background. The complement C1r and C1s proteases initiate the classical complement pathway within the C1 complex, but emerging evidence points to additional roles in tissues, including cell-intrinsic functions linked to cancer and connective tissue disorders. Few tools are availa...

Interface engineered perpendicular magnetic anisotropy-controlled propagation of magnetic domain

We report the impact of ferromagnetic layer thickness and stack configuration on the magnetic properties, perpendicular magnetic anisotropy (PMA), modified magnetization switching mechanisms, and creep regime domain wall (DW) dynamics, including their propagation velocity, in a P...

Overcoming Reversibility: Borrowing Hydrogen Enables Enantioselective Intermolecular Oxa-Michael Addition to α,β-Unsaturated Aldehydes

Abstract Chiral 1,3-dioxygenated motifs are key scaffolds in bioactive natural products, yet their synthesis via intermolecular oxa-Michael addition to α,β-unsaturated aldehydes remains challenging notably due to the high reversibility of the oxygenated nucleophile addition. This...

Immobilization of Alginate Microbeads With Whole‐Cells Expressing Nitrilase for Continuous Nicotinic Acid Production in Chip Millireactor

ABSTRACT The biocatalytic production of nicotinic acid using nitrilases has emerged as a promising alternative to conventional chemical synthesis, offering improved selectivity and environmental sustainability. In this study, we developed a continuous‐flow millireactor system emp...

Diffusion and gettering mechanisms of W and Fe in 300 mm silicon substrates

Metallic contamination is a major reliability issue in CMOS image sensor processing, where recombination-active impurities can increase dark current and pixel defects. In this work, the behavior of tungsten and iron is studied in several 300 mm silicon-based stacks under the same...

More is not always better: Dissociative photoionization limits the EUV absorbing photoacid generator pentafluorophenyl triflate in photolithography

Pentafluorophenyl triflate has been explored as a highly absorbing neutral photoacid generator (PAG) candidate for next-generation chemically amplified resists used in extreme ultraviolet (EUV) lithography. Although increased fluorination enhances EUV absorption, this study demon...

On the Cl2 plasma etching mechanisms of AlN micropillars: Carrier wafer impact

Plasma etching of aluminum nitride (AlN) is a critical step in the fabrication of advanced optoelectronic and electronic devices, particularly deep-ultraviolet light-emitting diodes based on nanowire architectures. In research and development, small AlN samples are commonly mount...

Direct Visualization of a Hydroperoxy Intermediate in Fluorescent Protein Chromophore Maturation in PAmCherry1

Abstract Despite the widespread use of fluorescent proteins in bioimaging, the mechanism of oxidative chromophore maturation to form the tyrosine Cα═Cβ double bond remains unclear. In the photoactivatable fluorescent protein PAmCherry1, this double bond has not yet been formed pr...

Molecular mechanism of calcium inhibition in viral channelrhodopsins

Abstract Viral channelrhodopsins (VCR1s) are giant-virus-encoded light-gated channels permeable to monovalent and divalent cations, including Na + and Ca 2+ ions, and inhibited by millimolar Ca 2+ concentrations. Here, we combine X-ray crystallography, time-resolved UV-vis spectr...

InN Nanowires on Si⟨111⟩ and Si⟨100⟩ for Monolithic Short-Wave Infrared (SWIR) Photodetectors

Abstract InN nanowires were grown on Si⟨111⟩ and Si⟨100⟩ substrates by plasma-assisted molecular beam epitaxy using a thin AlN buffer layer at temperatures compatible with the thermal budget limitation imposed by back-end-of-line processing. Reflection high-energy electron diffra...

Perinatal exposure to nano-polystyrene: deleterious imprinting on inflammatory bowel diseases

The extent of production and use of plastics leads to release of nanoplastics (NPL) into the environment, where they undergo weathering that could alter their toxicological properties. NPL enter the human food chain via contaminated food, and food packaging, and within the body t...

Indistinguishable single photons from a quantum dot in a nanopost cavity

Wavelength-tunable sources of single photons are key devices for scaling up optical quantum technologies. In this context, individual quantum dots (QDs) embedded in broadband photonic nanostructures are particularly appealing. The nanopost cavity, which is built with a segment of...

High‐Detectivity InGaAs/GaAsP Superlattice PIN Photodetector with a Thin Absorber on GaAs substrate for 1100 nm Applications

ABSTRACT III‐V materials exhibit superior optoelectronic properties compared to conventional semiconductors, making them ideal for short‐wavelength infrared (SWIR) photodetectors. These devices are in demand for applications such as telecommunications, LiDAR, and biomedical engin...

Compartmentalization of metals for photosynthesis and nitrogen fixation in specialized cells of the filamentous cyanobacterium Anabaena sp. PCC7120

Nitrogen fixing cyanobacteria, such as Anabaena sp. PCC7120, are some of the oldest multicellular organisms. When combined nitrogen sources are scarce, this cyanobacterium compartmentalizes photosynthesis and nitrogen fixation in vegetative cells and in differentiated heterocysts...

Solving the Gross-Pitaevskii equation with quantic tensor trains: Ground states and nonlinear dynamics

We develop a tensor network framework based on the quantic tensor train (QTT) format to efficiently solve the Gross-Pitaevskii equation (GPE), which governs Bose-Einstein condensates under mean-field theory. For sufficiently regular functions, the QTT approach enables exponential...

Trions as Fundamental Species in Chemically Doped Polymer Semiconductors

Doping is a cornerstone strategy for enhancing charge transport in semiconducting polymers, important for their application in, for example, semi-transparent electrode materials, thermoelectric devices, and antistatic coatings. Both chemical and electrochemical doping have, for t...