Catholic University of Korea

Age- and sex-adjusted genomic differences between Korean and Beat AML cohorts

Genomic profiling plays a central role in risk stratification and therapeutic decision-making in acute myeloid leukemia (AML), yet the clinical implications of population-specific genomic architectures remain incompletely defined. We conducted a prospective, multicenter study of...

Capturing Fast Gas Migration in Proteins

Small gases pose an unusual problem for studies of molecular transport in proteins. O2, CO, H2, and NO can cross short-lived internal spaces opened by protein fluctuations, often faster than experiments can follow continuous migration. Time-resolved crystallography can localize s...

Effects of Sarpogrelate Hydrochloride in Combination with Aspirin on Blood Viscosity and Hemorheological Parameters in Patients with Peripheral and Coronary Artery Disease: A Randomized Controlled Trial

Background/Objectives: Hemorheological abnormalities, including increased blood viscosity and impaired red blood cell (RBC) deformability, contribute to poor vascular outcomes in patients with atherosclerotic diseases. Although sarpogrelate has shown vascular benefits, its additi...

Genomic Reanalysis of Neurodevelopmental Disorders With and Without Epilepsy: Diagnostic Yield and Mechanisms of Newly Established Diagnoses

Background/Objectives: Genomic reanalysis may provide additional molecular diagnoses in patients with neurodevelopmental disorders (NDDs) whose initial genetic testing was nondiagnostic. We evaluated the diagnostic yield and mechanisms of newly established diagnoses in NDDs with...

Combined Ramp Lesion and Lateral Meniscus Root Tear Increase Rotational and Translational Instability in an Anterior Cruciate Ligament‐Deficient Knee: A Cadaveric Study

Purpose To evaluate knee instability associated with combined ramp lesion and lateral meniscus posterior root tear (LMRT) in an anterior cruciate ligament (ACL)‐deficient knee (the new terrible triad). Methods Ten cadaveric knees were tested biomechanically. Internal rotation (IR...

Changing Clinical Characteristics, Diagnostic Patterns, and Outcomes of Tuberculosis in South Korea: The Korean Tuberculosis Cohort, 2019-2024

BACKGROUND: Tuberculosis (TB) remains a public health concern in South Korea despite declining national notifications. We evaluated temporal changes in clinical characteristics, diagnostic patterns, and treatment outcomes in the Korean Tuberculosis Cohort (KTBC) from 2019 to 2024...

Association Between Artificial Sweetener Consumption and Bladder Cancer Risk: A Systematic Review and Meta-Analysis

Background:The potential association between artificial sweetener consumption and bladder cancer risk remains controversial.Therefore, we conducted a comprehensive metaanalysis synthesizing evidence from observational studies to elucidate this relationship.Methods: A systematic l...

Stereotactic body radiation therapy for hepatocellular carcinoma: 2026 expert consensus-based practical recommendation of the Korean Liver Cancer Association

Stereotactic body radiation therapy (SBRT) is a noninvasive, high-precision radiation technique that delivers a high dose to the tumor in a limited number of fractions, typically five or fewer, and is increasingly used as a curative-intent option for hepatocellular carcinoma (HCC...

Impact of Post-Primary Treatment Hormone Replacement Therapy on Survival in Women with Cervical Cancer

Background/Objectives: The effects of hormone replacement therapy (HRT) after primary treatment on survival outcomes in women with cervical cancer (CC) remain unclear. This nationwide cohort study evaluated the association between post-primary treatment HRT and overall survival (...

Synchronous Multicentric WHO grade 3 Oligodendroglioma and WHO grade 3 Astrocytoma : A Case Report and Literature Review

Multicentric gliomas are rare clinical entities, and cases exhibiting distinct histological lineages despite sharing a common molecular origin are exceptionally scarce. We report a unique case of synchronous multicentric gliomas in the bilateral frontal lobes of a 59-yearold fema...

Human Papillomavirus-Related Diseases in Urology: Diagnosis, Treatment, Prevention, and Clinical Considerations for Healthcare Providers

Human papillomavirus (HPV) has long been regarded as a gynecologic pathogen, yet its disease burden in men is substantial and rapidly increasing. In Korea, the prevalence of anogenital warts in men has tripled over the past decade, penile cancer continues to rise, and HPV-positiv...

Clinical and Ultrasonographic Characterization of Proposed Sjögren’s Disease Phenotypes in a Korean Longitudinal Cohort

Background/Objectives: The objective was to determine whether previously proposed Sjögren’s disease (SjD) subgroups can be pragmatically classified using routinely available clinical and laboratory data and to evaluate their associations with salivary gland ultrasonography (SGUS)...

Prevalence and Epidemiologic Characteristics of Acute Cystitis, Acute Pyelonephritis and Urinary Tract Infection: Population-Based Analysis Using Health Insurance Review and Assessment Service Bigdata From 2010 to 2024

Purpose: This study aims to investigate the long-term prevalence trends and epidemiological characteristics of acute pyelonephritis (APN), acute cystitis (AC), and other urinary tract infections (UTIs) in South Korea using nationwide big data.Materials and Methods: Data for ICD-1...

Integrative transcriptomic profiling reveals convergent coding and non-coding signatures in pediatric bone marrow failure syndromes

Abstract Pediatric bone marrow failure (BMF) comprises heterogeneous inherited and immune-mediated disorders, yet many cases remain genetically unclassified despite comprehensive genomic evaluation. To identify shared transcriptional features beyond protein-coding variation, we p...

All-trans retinoic acid suppresses CD8+ T-cell terminal exhaustion and potentiates anti-PD-1 therapy in glioblastoma

Terminal exhaustion of CD8⁺ T cells limits the efficacy of immune checkpoint blockade (ICB), particularly in glioblastoma, which is characterized by an immunosuppressive tumor microenvironment. Therefore, a better understanding of the regulators of terminal exhaustion could overc...

Impact of Concomitant Grade I Degenerative Spondylolisthesis on Clinical and Radiographic Outcomes Following Biportal Endoscopic versus Microscopic Laminectomy for Lumbar Spinal Stenosis: A Post Hoc Analysis of a Multicenter Randomized Clinical Trial

Study DesignPost hoc analysis.ObjectiveTo determine whether Meyerding grade I degenerative spondylolisthesis (DS1) modifies 12-month clinical or radiographic outcomes after biportal endoscopic laminectomy (BE-L) versus microscopic laminectomy (M-L) for lumbar spinal stenosis, and...

Identification of a Pathogenic RECQL4 1.6-kb Deletion–Insertion in a Neonate with Atypical Skeletal Phenotype of Baller–Gerold Syndrome Using Rapid Whole-Genome Sequencing

Mi-Ae Jang, M.D., Ph.D., Ja-Hyun Jang, M.D., Ph.D., Jin Kyu Kim, M.D., Ph.D., Joonhong Park, M.D., Ph.D., Go Hun Seo, M.D., Ph.D., Misun Yang, M.D., Ph.D., Yun Sil Chang, M.D., Ph.D., and Hyun Ho Kim, M.D., Ph.D.. Ann Lab Med -0001;0:. https://doi.org/10.3343/alm.2026.0102

Hyperacute Cytokine Kinetics and Early Interleukin-10 Elevation as Predictors of Neurological Outcome in Post-Cardiac Arrest Syndrome

Background: Post-cardiac arrest syndrome (PCAS) involves a complex interplay between systemic inflammatory and compensatory anti-inflammatory responses. The hyperacute kinetics of these cytokines and their incremental prognostic value beyond established brain injury biomarkers re...

Pulsed Field Versus Cryoballoon Ablation for Atrial Fibrillation: Procedural Outcomes and Hemolysis-Related Laboratory Changes in a Single-Center Pilot Study

Background and Objectives: Pulsed field ablation (PFA) and cryoballoon ablation (CRYO) are established approaches for pulmonary vein isolation in atrial fibrillation (AF). Given emerging concerns regarding hemolysis following PFA, this pilot study aims to directly compare outcome...

Original and Modified Sauvé–Kapandji Procedures: A Two-Axis Framework for Surgical Decision-Making—A Narrative Review

The Sauvé–Kapandji (SK) procedure is a salvage operation that fuses the distal radioulnar joint (DRUJ) and creates an intentional pseudarthrosis in the proximal ulna, thereby relieving pain while preserving forearm rotation and ulnar-sided bony support. This narrative review (1)...