Carl von Ossietzky Universität Oldenburg

A cardiovascular-motor axis framework for perfusion-mediated motor impairment

Cardiovascular disease is the leading cause of death worldwide, and among survivors of heart failure, peripheral arterial disease, valvular disease, and atrial fibrillation many develop motor impairment: weakness, slow gait, sarcopenia, frailty. These deficits are usually attribu...

A new species of Squamulea (Teloschistaceae) from the Himalayan Region

Squamulea pakistanica sp. nov. is a newly discovered lichen species from the Himalayan moist temperate forests of Pakistan. The genus Squamulea (Teloschistaceae) includes squamulose or subfoliose taxa, many of which are understudied in South Asia. This study aims to characterize...

Agranulocytosis associated with metamizole among EudraVigilance reports involving methotrexate for rheumatoid arthritis

Methotrexate (MTX) can induce adverse drug reactions (ADRs) including severe haematotoxic events. This study analyses whether agranulocytosis is disproportionately reported in spontaneous reports involving MTX for rheumatoid arthritis (RA) when use of metamizole, a non-opioid ana...

Delirium superimposed on dementia in nursing homes: prevalence, incidence, and prognosis – protocol of a prospective multicenter cohort study

Abstract Background Delirium is a frequent and serious neuropsychiatric syndrome in older adults. People living with dementia are at particularly high risk of developing delirium. In nursing homes, where dementia prevalence is high, delirium superimposed on dementia (DSD) represe...

Homicide at home: setting the agenda for an international collaboration to improve support for children bereaved due to family violence

Background: Bereavement due to fatal family violence (e.g. intimate partner homicide, filicide, parricide, siblicide) is a profoundly disruptive experience for children, with lifelong psychosocial consequences. Although the need for fatal family violence prevention is increasingl...

DECIDER-2: Prospective randomized multicenter phase III trial of decitabine and venetoclax administered in combination with all-trans retinoic acid or placebo in patients with acute myeloid leukemia who are ineligible for induction chemotherapy

Abstract Background Acute myeloid leukemia (AML) is predominantly a disease of older patients with a poor long-term survival. Approval of the combination of venetoclax (VEN) with azacitidine (AZA) or decitabine (DAC) in the European Union in 2021 for the treatment of patients wit...

Multiscale carrier-envelope phase characterization of 2-µm pulses delivered by a 200-kHz optical parametric amplifier

Abstract Light fields with a central wavelength of 2 µm are very well suited for strong-field-driven charge carrier control: Their photon energy lies far below the band gap of many materials, while their oscillation period remains significantly shorter than the coherence time of...

Back to the Future of qEEG: Lifespan Normative Modeling of Spectral Ratios and Functional Indices with Potential Applications to Therapeutic Monitoring

Quantitative EEG (qEEG) provides objective, millisecond-resolution measures of brain dynamics. Despite decades of methodological advances, clinically relevant derived indices-spectral power ratios, cognitive-emotional state markers, and physiological parameters-are typically repo...

Novel class identification: A human‐in‐the‐loop approach for efficient species recognition in bioacoustic data

Abstract Passive acoustic monitoring (PAM) is widely used to collect large‐scale wildlife data encompassing many species, but efficiently identifying all species—particularly rare and potentially endangered ones—without exhaustive manual examination of the entire dataset remains...