Cancer Research And Biostatistics

Entropic Optimal Transport Eigenmaps for Nonlinear Alignment and Joint Embedding of High-Dimensional Datasets

Abstract. Embedding high-dimensional data into a low-dimensional space is an indispensable component of data analysis. In numerous applications, it is necessary to align and jointly embed multiple datasets from different studies or experimental conditions. Such datasets may share...

Barriers to Reducing Subthreshold Phototherapy for Neonatal Jaundice

OBJECTIVE: In a national, multicenter quality improvement (QI) collaborative to reduce subthreshold inpatient phototherapy, the proportion of subthreshold encounters was high at baseline and remained high after the intervention period. This study aimed to assess why clinicians st...

Capturing Heterogeneous Time‐Variation in Covariate Effects in Non‐Proportional Hazard Regression Models

ABSTRACT A central focus in survival analysis is examining how covariates affect survival time. These covariate effects are often found to be either time‐varying, heterogeneous—such as being specific to patients, treatments, or subgroups—or exhibit both characteristics simultaneo...

Local control of RCC pancreatic metastases is obtained by angiogenesis inhibitors

Background Metastatic clear-cell renal cell carcinoma (m-ccRCC) with pancreatic and/or thyroid metastases (PM/TM) is sensitive to vascular endothelial growth factor receptor tyrosine kinase inhibitors (VEGFR-TKIs). Optimal first-line therapy for these patients (VEGFR-TKI-monother...

Interpreter Use and Challenges in Primary Care

This survey study investigates use of interpreters and challenges experienced by physicians treating patients with limited English proficiency.

LINGO1-targeted antibody-drug conjugates improve efficacy and tolerability of antineoplastic therapies in Ewing sarcoma models

We reported LINGO1 as a potential marker on Ewing sarcoma cells that could enable targeted drug delivery, improving treatment effectiveness while reducing side effects.

Shotgun Metagenomics Identify Unique Changes of the Intestinal Microbiome in Pediatric Survivors of Acute Lymphoblastic Leukemia.

BACKGROUND: Intestinal microbiota plays an important role in human health and metabolism. Microbial dysbiosis has been observed in various chronic conditions, many of which are late effects of leukemia treatment. We previously observed significant differences in the gut microbiom...