Cambridge School

Interventions to Support Parents Whose Babies Cry Excessively: Systematic Review

CONTEXT: Parents report that around 10% to 20% of babies cry a lot without an apparent reason during early infancy. This "excessive" infant crying can lead to adverse outcomes, including parental depression, breastfeeding cessation, impaired parent-child relationships, and, in ex...

Diffusion Anisotropy Predicts Directional Progression After Complete Resection of Frontal Glioblastoma

BACKGROUND AND OBJECTIVES: Despite complete resection of contrast-enhancing tumor, glioblastoma frequently progresses due to microscopic invasion beyond surgical margins. In frontal glioblastoma, functional tolerance of anterior and lateral regions enables consideration of supram...

GPR35-positive mast cells are enriched in primary sclerosing cholangitis and show an enhanced secretory phenotype

OBJECTIVE: dependent mast cell biology relevant for cholangitis and biliary fibrosis. METHODS: knockdown were determined by DESeq2 and gene set enrichment analysis. Selected cytokines, TNFα and IL13, were measured by qRT-PCR and ELISA. Mast cell-cholangiocyte interaction was stud...

Investigating the clinical utility of plasma succinate with insights from a Sdhb deficient murine model

Abstract The succinate dehydrogenase (SDH) enzyme composed of four subunits (A-D) has a key role in the Krebs cycle and oxidative phosphorylation. Germline pathogenic variants (GPV) in the genes encoding the four subunits of the succinate dehydrogenase (SDH) enzyme (SDHA/SDHB/SDH...

Receptor tyrosine kinase targeted therapies in glioblastoma: a systematic review

Introduction Glioblastoma is the most common primary central nervous system malignancy and has a median survival of 14.6 months. Receptor tyrosine kinase (RTKs) signalling consitutes one of the three major pathways driving glioblastoma, implicating them as a therapeutic target. H...

Perceived pleasantness mediates the effects of high-arousal and emotionally complex music on pain

ABSTRACT: Music effectively reduces pain, yet the mechanisms underlying music-induced hypoalgesia remain poorly understood. We investigated how latent perceptual dimensions of music influence pain by examining both stimulus properties and subjective evaluations of those propertie...

Impact of LIFE training on educational staff’s suicide prevention skills and confidence levels

Purpose This study aims to assess the impact of LIFE training on educational staff’s confidence in communication skills that can support students in suicidal distress. Design/methodology/approach LIFE training is a school-based suicide prevention course designed to develop educat...

Bifunctional Phagocytic Synapse Enhancers Remodel the Tumor Microenvironment to Overcome Immunosuppression

Abstract Current immunotherapies often fail in immunologically “cold”, macrophage-rich tumor microenvironments (TMEs). Multi-targeting approaches that modulate innate-adaptive immune activation represent a promising frontier in cancer immunotherapy. Here, we developed phagocytic...

Maternal DNA repair safeguards genome stability during the oocyte-to-embryo transition

Abstract De novo mutations are a major source of genetic variation and disease risk, yet the developmental timing and mechanisms underlying their origin require further investigation. While germ cells have traditionally been considered the primary source of these mutations, incre...

Dual effect of α-synuclein disease variants on condensate formation

Abstract α-synuclein is a pre-synaptic protein implicated in synucleinopathies including Parkinson’s disease, Parkinson’s disease dementia, and dementia with Lewy bodies, where it accumulates in intracellular aggregates termed Lewy bodies and Lewy neurites. Recent studies have re...

Latent paths in mode choice models: incorporating street-level environment features for active travel policy

There is growing empirical evidence that walking and cycling are influenced by street-level environment features such as greenness and traffic stress. To assess active travel policy, these features are increasingly incorporated into mode choice models through predictors that aggr...

What Could ‘Manchesterism’ Mean?: Infrastructural Citizenship for Civic Renewal

ABSTRACT Local infrastrucutre is a lens through which citizens materially experience the actions of the state. Drawing on the concept of 'infrastructural citizenship', this paper explores how shared spaces can shift from sources of alienation to catalysts for trust. To anchor the...

Early Longitudinal Brain Network Changes in Huntington's Disease Before Clinical Motor Onset

Abstract Background Longitudinal studies of seed‐based functional connectivity (SBFC) in young adult Huntington's disease gene‐expanded (HDGE) individuals are rare, and none, to our knowledge, have examined adult cohorts decades from predicted clinical motor diagnosis. Objectives...