California University of Pennsylvania

Safety and Efficacy of Left Atrial Ablation After Percutaneous Left Atrial Appendage Occlusion in High-Bleeding-Risk Patients with Atrial Fibrillation: A Multicenter Analysis from the PROCEED-AF Ablation Registry

BACKGROUND AND AIMS: Patients with left atrial appendage (LAAO) devices are increasingly referred for AF ablation, yet anticoagulation strategies remain uncertain. The goal of this study was to evaluate the safety and efficacy of catheter ablation for atrial fibrillation (AF) in...

Large-scale patterns of self-reported mood and sleep across the day and week on an online cognitive-training platform

Mood follows a well-documented circadian rhythm. Sleep timing and duration are similarly shaped by biological and social factors. However, large-scale, real-world data on how these patterns vary across demographic groups remain limited. Prior studies often rely on laboratory data...

The Simons Observatory: Development of a Pipeline to Detect Rapid Transients in Time-Ordered Data

We introduce a method for detecting astrophysical transients evolving on timescales of milliseconds to minutes using cosmic microwave background (CMB) survey telescopes. While previous transient searches in CMB data operate in map space, our pipeline directly processes the raw ti...

Ti3C2T x MXene-Enhanced Paper-Based Ion-Selective Electrodes for Sweat Sodium Monitoring

Abstract Electrolyte balance plays a fundamental role in maintaining physiological homeostasis, as ionic fluctuations regulate cellular excitability, osmotic gradients, and neuromuscular signaling. Among electrolytes, sodium (Na+) is a critical biomarker for hydration status and...

27. EPIGENOME-WIDE ANALYSIS REVEALS DISTINCT DNA METHYLATION PROFILES FOR OPIOID DEPENDENCE VERSUS OPIOID EXPOSURE

Background The U.S. opioid epidemic represents a serious public health crisis. While epigenetic mechanisms have been linked to opioid use disorder (OUD), more research is needed to identify actionable biomarkers that distinguish opioid exposure from opioid dependence. In this stu...

W1. POSTPARTUM STRESS CAUSES TRANSCRIPTOMIC AND EPITRANSCRIPTOMIC CHANGES IN THE BASOLATERAL AMYGDALA OF RAT DAMS

Background Maternal postpartum stress caused by low resource parenting can produce enduring affective and stress-reactivity phenotypes in offspring, yet the effects on the maternal brain are largely unexplored. We aimed to define how postpartum stress reshapes isoform usage and t...

A Mesoscopic Ginzburg–Landau Model for Vibrational Strong Coupling Enhanced Rayleigh Scattering in Molecular Liquids

Abstract Recent experiments by Sandeep et al. [Angew. Chem. Int. Ed.65, e16917 (2026). ] suggest that vibrational strong coupling (VSC) in molecular liquids can generate mesoscopic phenomena beyond single-molecule observables, including resonantly enhanced Rayleigh scattering, ab...

Spirituality in End-Of-Life Care: Tips and Tools for all Physicians

Many physicians find themselves with patients when life’s final horizon is approaching but feel ill-equipped when they cannot take the suffering away. If a patient has no discernible chance of recovery, praying for healing seems disingenuous, and yet expressing condolences seems...

Self-Catalyzed Transesterification Transforms Ionizable Amphiphilic Janus Dendrimers into Multicomponent Vectors and Generates Complex Design Strategies for mRNA Delivery

Abstract Genetic nanomedicine delivers nucleic acids by viral and synthetic vectors to produce drugs directly in the body’s own cells. Each approach presents relative advantages, but synthetic vectors are distinguished by their effectively unlimited synthetic capabilities. The le...

Trends in trajectories and incidence of functional impairment in middle-aged Americans

The prevalence of functional impairment (i.e., difficulty performing daily activities such as bathing and dressing) has increased among middle-aged Americans, but longitudinal data are lacking. The objective of this study was to examine trajectories of functional status and incid...

The education alibi: tracing education’s entanglements across contemporary Africa

In The Education Alibi: Tracing Education’s Entanglements Across Contemporary Africa, edited by Elizabeth Cooper, Erdmute Alber, and Wandia Njoya, the authors reject education as a neutral institut...

Tideglusib as a First-in-Class Chemical Probe for NatA: Identification, Mechanism, and Cellular Validation of an Allosteric, CoA-Dependent Inhibitor

N-terminal acetyltransferase A (NatA) catalyzes 40-57% of eukaryotic Nα-acetylation, a co-translational modification critical for protein stability, localization, and function, yet no validated small-molecule probe of NatA has been reported. Here, we describe the discovery and ch...

The Luminosity Function of Ultrafaint Trans-Neptunian Objects Detected by JWST

Abstract We present a definitive discovery of 27 trans-Neptunian objects (TNOs) using the Near-Infrared Camera aboard the James Webb Space Telescope (JWST). By employing a shift-and-stack technique and a machine learning network geared specifically to identifying false-positive d...

Adaptive judgment in the cognitive reflection test: A computational analysis

The Cognitive Reflection Test (CRT) is widely used in reasoning and decision making research, but it lacks a formal cognitive foundation. As a result, debates persist over why CRT scores correlate with mathematical ability, why some individuals solve CRT problems easily while oth...

Catalyst-Free Urea Synthesis from Methanol and Nitrogen via Radical-Mediated Redox Coupling on Aqueous Microdroplets

Abstract Urea is an indispensable nitrogen fertilizer and an important feedstock for chemical synthesis. Compared to the energy-intensive Bosch–Meiser process, photocatalytic redox coupling offers a sustainable approach toward urea synthesis. However, artificial photosynthesis re...

Coherent Pulsed Dynamic Nuclear Polarization with Endogenous Metal Ions

Abstract Dynamic nuclear polarization (DNP) can overcome the intrinsically low sensitivity of nuclear magnetic resonance (NMR) and enable structural characterization of a wide range of materials. In inorganic solids, DNP can be achieved endogenously by introducing paramagnetic me...

jBOT: Semantic jet representation clustering emerges from self-distillation

Self-supervised learning, in the context of foundation model training, is a powerful pre-training method for learning feature representations without labels, which often capture generic underlying semantics from the data and can later be fine-tuned for downstream tasks. In this w...

Multiscale characterization of cortical signatures in positive and negative schizotypy:a worldwide ENIGMA study

Positive and negative schizotypy reflect distinct patterns of subclinical traits in the general population associated with neurodevelopmental and schizophrenia-spectrum pathologies. Yet, a comprehensive characterization of the unique and shared neuroanatomical signatures of these...

A Mammalian High-Throughput Screen for AI-Designed Peptide-Guided Protein Degraders

Targeted protein degradation (TPD) offers a route to eliminate disease-driving proteins that remain inaccessible to conventional inhibitors. However, degrader discovery remains low-throughput, labor-intensive, and dependent on randomized libraries or non-human display systems, li...

A Mammalian High-Throughput Screen for AI-Designed Peptide-Guided Protein Degraders

Targeted protein degradation (TPD) offers a route to eliminate disease-driving proteins that remain inaccessible to conventional inhibitors. However, degrader discovery remains lowthroughput, labor-intensive, and dependent on randomized libraries or non-human display systems, lim...