California University of Pennsylvania

Engineering a biomimetic multiphasic suture anchor system for enhanced rotator cuff enthesis regeneration

Abstract Conventional suture anchor methods in rotator cuff repair often fail to replicate the native tendon-to-bone interface, leading to re-tears due to stress concentrations and poor biological integration at anchor sites. To address these challenges, we engineered a biomimeti...

Improved specificity of a probe-based real-time PCR for the detection of Dirofilaria immitis in canine blood

Abstract Background Dirofilaria immitis is a vector-borne filarioid nematode distributed worldwide and endemic across most of North America. In dogs, it is considered the most important parasite and a known cause of acquired cardiomyopathy. Clinically, canine heartworm disease ca...

Strontium Varied Across the City: 87 Sr/ 86 Sr Values at Ur (Tell al-Muqayyar, Iraq)

Analyses of isotope ratios provide researchers with evidence of past and present environments, ecologies, diets and more. For isotope analyses to be maximally effective, however, multiple forms of baseline knowledge need to be gathered. This paper contributes to filling key gaps...

AI safety evaluation in an underrepresented population: real-world performance of clinical decision support and frontier language models on Medicaid patient messaging triage

<title>Abstract</title> Background. Studies of artificial intelligence tools used in patient triage have largely involved academic medical center cohorts, scripted patient-actor scenarios, or knowledge benchmarks. Populations that may rely on such tools due to constrained access...

Conceptual Shift inOur Understanding of DegenerateRadical Spin Systems: Spin-Rotation Coupling Turned on Its Head

Abstract For most chemists, Kramers’ degeneracy refers to the fact that for any radical system, every potential energy surface is at least doubly degenerate (with spin up and spin down, time-reversed solutions) for all nuclear positions X. Yet, as is well-known to the community o...

Mining of NovelHuman DPP-IV-Targeting Tripeptidesthrough Multicomputational Screening and In Vitro Validation for DiabetesTherapy

Abstract Inhibition of human dipeptidyl peptidase IV (hDPP-IV) is considered an effective strategy in the management of type 2 diabetes (T2D). However, the lack of high-throughput screening approaches and the high cost of experimental evaluation have limited the discovery of pept...

Geometric Engineeringof Flat Bands in a Single-LayerPhotonic Graphene

Abstract Photonic flat-bands offer significant potential for light–matter interactions and nonlinear optics, thanks to their localization of light and high density of states. However, realizing flat-bands requires intricate fabrication, alignment, and/or specialized geometries. H...

Spontaneous ChlorineGeneration via Interfacial Oxidationof Chloride by O2 on Acidic Microdroplets

Abstract Reactive chlorine species significantly influence atmospheric chemistry, yet their sources remain inadequately defined. We have discovered a spontaneous formation pathway for substantial molecular chlorine (Cl2) from the oxidation of chloride (Cl–) through interfacial ox...

Identifying Ice-Philic Protein Patches to Inform theIce-Binding Sites of Antifreeze Proteins

Abstract Antifreeze proteins (AFPs) inhibit ice growth and recrystallization by binding to ice crystals via specific regions on their surface, known as ice-binding sites (IBS). Although the IBS of certain AFPs display regularly spaced threonine residues that are matched well with...

Near-Infrared Fluorescence Imaging and Photothermal Therapy of Tumors Using a Targeted Helical Protein Scaffold

Abstract Photothermal therapy (PTT) using near-infrared (NIR) photoactive agents offers a minimally invasive approach for tumor ablation; however, many existing platforms rely on polymeric or nanoparticle carriers that limit targeting precision and control over dye loading. Here,...

MitigatingSO2 Poisoning Effect in ElectrochemicalCO2 Reduction with Transition-Metal Single-Atom MolecularCatalysts

Abstract The electrochemical CO2 reduction reaction (CO2RR) offers a promising approach for converting captured CO2 into valuable chemicals and fuels. However, CO2 streams from industrial sources often contain SO2 impurities, which compromise the performance and stability of many...

Gene expression and water transport in plants: A molecular introduction to plant physiology

&lt;p&gt;&amp;ldquo;Gene expression and water transport in plants: A molecular introduction to plant physiology&amp;rdquo; is an introductory biology activity that helps students understand the relationship between cellular and molecular properties regulating plant physiology. Th...

Escaping the Plantationocene: plotting the future of education

Purpose This article critically analyses the ways in which contemporary international educational development perpetuates plantation systems. It proposes ways to plot an escape from the plantation's extractive education monoculture and move towards multi-epistemological flourishi...

Drug stock-outs in HIV, tuberculosis, and malaria programs: a systematic review

Background Stock-outs of antiretroviral, anti-tuberculosis, and anti-malarial medicines remain a major challenge in low- and middle-income countries, affecting both health systems and patient outcomes. This systematic review aimed to synthesize evidence on the causes, consequence...