California Institute of Technology

Enantiodivergent Carbon–PhosphorusBond Formationvia Enzymatic Carbene Insertion

Abstract Phosphorus is one of the six elements of life, yet enzymatic carbon–phosphorus (C–P) bond formation is exceedingly rare in nature. This gap in the biosynthetic toolkit is particularly consequential, given the prominence of stereogenic-at-phosphorus P(V) scaffolds in phar...

Towards scalable AI-assisted pre-bunking of election misinformation: evidence from a pre-registered US panel experiment

Abstract We present a scalable artificial intelligence (AI)-assisted framework for rapidly generating ‘pre-bunking’ articles against election misinformation. Our approach uses a stable template structure that, once finalized through human review, can be quickly adapted to counter...

Solvent and Salt Effects on Mononucleotides

No abstract.

Low Molecular Weight Substrates for Lysozyme

Preparation of short chain polymers of N-acetylglucosamine by acid hydrolysis of chitin was undertaken. Separation of the various chain lengths of the hydrolysis breakdown products was done by column chromatography on charcoal-celite with an ethanol solvent. Preparation of the di...

The Synthesis of Propidium Iodide

The dye-buoyant-density method for separation of circular and linear DNA is reviewed, and an improved dye proposed. The synthesis of the dye is described, and its feasibility as a general method discussed.

Hydrodynamic Shear Breakage of Deoxyribonucleic Acid

Deoxyribonucleic acid (DNA) was broken by hydrodynamic shear in a capillary. The effects of parameters associated with chemical reactions, temperature, catalysts, and ionic strength, were examined to determine the possible effect of a chemical reaction upon the breakage. No catal...

Multiple Angle, High Resolution Photoelectron Spectroscopy

A variable angle, high resolution photoelectron spectrometer has been built and is now being put into operation. This instrument, which uses 180 degree hemispherical analysers of 2.5 inch mean radius and a cylindrical scattering chamber, is thought to be different enough from pre...

Enzyme-Substrate Interaction by Nuclear Magnetic Resonance

The chemical shifts of the nuclear magnetic resonances of N-acetyl-D-tryptophan are measured and compared to those observed when bound to ∝-chymotrypsin. Chemical shift changes of 1 Hz. are reported for a solution with 1% total substrate bound to the enzyme.

Nuclear Magnetic Resonance Spectroscopy: Spin Decoupling and Inversion Rate Determination

The technique of spin decoupling (double irradiation) was investigated and developed. Inversion rates for a small bicyclic ring compound were determined as a function of temperature.

The Crystal Structure of Nickel Ethylenedibiguanide Chloride Monohydrate

The crystal structure of nickel ethylenedibiguanide has been determined from three-dimensional, x-ray diffractometer data (3087 reflections). The compound, Ni(C6H16N10)Cl2·H2O, crystallizes in the centrosymmetric monoclinic space group P21/c. The unit cell contains four molecules...