Bridge University

Biomechanical analyses point to dense collagen fibre architecture in an Ediacaran frond

Ediacaran macrofossils record the earliest large and complex organisms on Earth. Despite extensive study, fundamental aspects of their internal anatomy and tissue composition remain poorly known, limiting understanding of how these organisms were constructed and functioned, as we...

Serological and transcriptomic response of African fruit bats to immune challenge with recombinant vaccines expressing Ebola or Nipah virus antigens

Abstract Bats are hosts to diverse zoonotic viruses which can cause high case fatality rates in humans. Since detecting viruses in bats is difficult, antibodies are often used for surveillance, though their significance remains unclear in the absence of in vivo immunological stud...

Michael John Whelan

Abstract Mike Whelan was a physicist with outstanding practical and theoretical skills. He employed them boldly in his key role of bringing to fruition and further development the idea of imaging dislocations and other crystal defects with the electron microscope. His work not on...

Establishing Stakeholder Priorities for Development of a Multi‐Arm Multi‐Stage Platform Trial in Crohn's Disease

ABSTRACT Background and Aims The expanding range of advanced therapies for Crohn's disease (CD) has increased complexity in treatment selection, particularly in refractory disease. Conventional randomised controlled trials are limited in evaluating multiple treatment strategies e...

Decoupled Dielectric Optimization and YbO x Contact Engineering in All‐Spray‐Processed Oxide Thin‐Film Transistors

ABSTRACT Control of dielectric transport and contact energetics remains a central challenge in scalable oxide electronics. We present a decoupled optimization strategy for fully spray‐processed oxide thin‐film transistors with In 2 O 3 :W channels, where dielectric densification...

Teaching Climate Change and Geography: Towards a Climate Education Pathway

ABSTRACT This is a crucial moment to reflect on climate education. Young people demand and deserve deeper knowledge, skills and understanding of climate change. Following the 2025 English Curriculum and Assessment Review, this commentary reflects on the relationship between geogr...

Disentangling local adaptation and phenotypic plasticity in traits associated with altitude and temperature in widespread tropical butterflies

Climatic stratifications, in particular differences in temperature, occur along altitudinal clines. Understanding divergence across these regions can give insight into speciation and diversification, as well as how species may respond to climate change scenarios. Most past resear...

Nature‐Inspired Histidine and Guanidine Modification of Magnetic Nanoparticles for Urinary DNA Liquid Biopsy

ABSTRACT Urinary cell‐free DNA (cfDNA) is a promising substrate for non‐invasive liquid biopsy analysis and biomarker detection. However, the lack of standardized pre‐analytical workflows and the intrinsic challenges associated with isolating highly dilute and fragmented cfDNA li...

Investigating the clinical utility of plasma succinate with insights from a Sdhb deficient murine model

Abstract The succinate dehydrogenase (SDH) enzyme composed of four subunits (A-D) has a key role in the Krebs cycle and oxidative phosphorylation. Germline pathogenic variants (GPV) in the genes encoding the four subunits of the succinate dehydrogenase (SDH) enzyme (SDHA/SDHB/SDH...

Addressing evidence gaps in haemodialysis care: a critical review of clinical trials, technological innovations, and implementation priorities

Kidney failure treated with maintenance haemodialysis (HD) carries high risks of premature mortality, hospitalisation and impaired quality of life, yet important evidence gaps persist across routine HD care. The Dialysis Research Innovation Network, part of the UK Kidney Research...

Can discussions with patients and the public clarify missing data mechanisms for digital outcome measures?

Abstract Background Analysis of clinical trials with missing data requires statistical assumptions. When novel digital outcome measures are used, it is particularly important to understand trial participants’ experiences with the device. This can illuminate the reasons for and sp...

Depressive Symptoms Trajectories Across the Transition to Cardiovascular Disease in Middle-Aged and Older Adults: A Multicohort Study

Abstract Aims The long-term depressive symptoms trajectories across the transition to diagnosed cardiovascular disease (CVD) remain poorly characterized. We aimed to investigate trajectories of depressive symptoms before and after incident CVD in multinational aging populations....

Bifunctional Phagocytic Synapse Enhancers Remodel the Tumor Microenvironment to Overcome Immunosuppression

Abstract Current immunotherapies often fail in immunologically “cold”, macrophage-rich tumor microenvironments (TMEs). Multi-targeting approaches that modulate innate-adaptive immune activation represent a promising frontier in cancer immunotherapy. Here, we developed phagocytic...

AI for Science: Reframing AI’s Role in Discovery

Abstract Digital computers have reshaped scientific practice, moving working scientific knowledge from printed texts into algorithms, simulations, and models. Advances in artificial intelligence (AI) are now accelerating that shift, progressing science in areas from protein foldi...

Modeling of Diamond Trench Metal Oxide Semiconductor Barrier Schottky Rectifier Based on Dynamic Reverse Bias Simulation Framework

This work presents an electrothermal optimization study of diamond‐based trench metal oxide semiconductor (MOS) barrier Schottky (TMBS) rectifiers using mixed‐mode drift‐diffusion technology computer aided design simulations under quasi‐static and dynamic reverse‐bias conditions....

20 Design and development of a novel digital shared decision making aid for glioblastoma patients

Abstract Introduction Facilitating shared decision-making (SDM) and incorporating patient decision aids are recommended by the National Institute for Health and Care Excellence (NICE). However, there is a lack of SDM aids for the specific treatment of high-grade glioma patients....

45 Predicting sites of tumour progression in the invasive margin of glioblastomas (PRaM-GBM Study): a multicentre imaging study

Abstract Introduction Despite advances in surgery and radiotherapy, glioblastoma patients often experience progression within a year, adjacent to the resection cavity. Conventional imaging techniques are not sensitive enough to detect invasive tumour, leaving occult tumour undete...

Graph-based complexity and computational capabilities of proteinoid spike systems

Abstract Proteinoid microspheres exhibit oscillatory electrical dynamics that encode rich temporal structure. We analyse five proteinoid spike-train datasets using a two-step nonlinear transformation based on spiral sampling and significant-digit extraction, producing a multi-nod...

Education, diversity and progress

Abstract Around the world, girls and women are much less likely to be able to access a good education, and even in countries like the UK, stereotyping can deter girls from pursuing careers in subjects like the physical sciences, engineering and computing. Yet, many daily decision...

Programmable multifunctional microrobots for synergistic cuproptosis-immunotherapy

Abstract Oral microrobots as drug carriers have shown great promise in enhancing the therapeutic efficacy of colorectal cancer (CRC). However, existing platforms frequently lack the programmable temporal precision required to execute complex, multi-stage dosing regimens. Here, we...