Bispebjerg Hospital

EMS response time and patient outcomes in high-acuity emergency responses: a Danish matched cohort study

Emergency medical services (EMS) provide prehospital care. To reduce response times, ambulances may use lights, sirens, and traffic exemptions, increasing risks for EMS personnel and other road users. Additionally, predefined response time targets may lead to inefficient resource...

Investigating Potential Adverse Drug Reactions of Lisdexamfetamine Using Sequence Symmetry Analysis

ABSTRACT The prevalence of ADHD is increasing rapidly, and lisdexamfetamine is increasingly popular, but few studies investigate its safety. We performed a sequence symmetry analysis (SSA) using Danish register data to identify potential ADRs associated with lisdexamfetamine in 2...

The SocMed Database: coverage and clinical characteristics of individuals seen in social medicine in the capital region of Denmark

This study aimed to describe The SocMed Database, its content, completeness, and representativeness compared with the Danish National Patient Register (DNPR), alongside population characteristics within a biopsychosocial framework. In Denmark, Departments of Social Medicine manag...

Glutamate levels in antipsychotic-free, first-episode psychosis: a 7-tesla MRS study across five brain regions

Disrupted glutamatergic signaling across cortical and subcortical circuits is increasingly recognized as a critical player in the pathophysiology of psychosis. Using ultra-high-field (7 Tesla) proton MRS, we quantified glutamate levels across five brain regions in antipsychotic-f...

Development of osteoarthritis in adults with untreated hip dysplasia: a longitudinal observational study

BACKGROUND AND PURPOSE: Although hip dysplasia is a risk factor for osteoarthritis (OA), its natural progression in adults remains poorly understood. In a longitudinal observational study, we aimed to estimate differences in OA incidence, time to OA, and minimum joint space width...

Awake or Asleep Subthalamic Deep Brain Stimulation for Parkinson's Disease: Further Research Is Needed

BACKGROUND AND OBJECTIVES: This systematic review aims to evaluate the differences in clinical efficacy and quality of life between asleep and awake subthalamic nucleus deep brain stimulation (STN-DBS) procedures in patients with Parkinson's disease. METHODS: A comprehensive sear...

Non‐contrast CT Markers of Hematoma Expansion and Andexanet Response in Factor Xa Inhibitor‐Associated Intracerebral Hemorrhage: An Analysis from ANNEXa ‐I Trial

In this post hoc analysis of the ANNEXa-I trial (n = 434), we evaluated non-contrast computed tomography (NCCT) markers of hematoma expansion (HE) in factor Xa inhibitor (FXai) -associated intracerebral hemorrhage (ICH). At least one NCCT marker was present in 72.1%, and HE (≥12....

Copenhagen longitudinal study on quality of life in a young adult population with gliomas

Abstract Background Patients diagnosed with glioma in the brain are prone to lowered quality of life (QoL). The risk of neurological symptoms and emotional burden may restrict participation in everyday life.The glioma diagnosis is considered chronic with a limited overall surviva...

Sex- and fiber type-specific remodeling of the muscle proteome implicates CSRP3 in resistance training-induced hypertrophy

Skeletal muscle hypertrophy is a hallmark of resistance training that improves health and longevity. However, despite physiological differences between sexes and fiber types, the underlying proteome changes with resistance training have not been studied in a sex- and fiber type-s...

Use of Attention Deficit Hyperactivity Disorder Medication Among Danish Children and Adolescents From 2010 to 2023

Introduction: Pharmacological treatment is an important component in the multimodal management of attention deficit hyperactivity disorder (ADHD), but contemporary trends in ADHD medication use among boys and girls in Denmark have not been fully characterized. This study aimed to...

Clinical relevance of pharmacogenomic information for improving prescribing practices in acutely admitted older medical patients

AIMS: Safe prescribing and effective medication review during acute hospitalization depends on accurate information about liver and kidney function because these organs are responsible for the elimination of most medications. While estimates for kidney function are widely used, c...

Poisoning With Toxic Alcohols in Denmark

INTRODUCTION: Poisoning with ethylene glycol and methanol remains a recurrent problem in Scandinavia. This study aimed to describe the epidemiology, exposure circumstances, clinical characteristics and management of toxic alcohol poisonings reported to the Danish Poison Informati...

Circulating biomarkers reflecting type III, IV and VI collagen remodeling are present in lung tissue of patients with pulmonary fibrosis and non-fibrotic controls

Abstract Background The extracellular matrix (ECM) is a dynamic network that provides structural support and maintains tissue homeostasis. Collagens are the main structural components of the ECM, occupying distinct tissue compartments and serving specialized roles. Dysregulated E...

Treatment of striae albae with combination of fractional radiofrequency and topical tretinoin: A randomized controlled trial

Mature striae distensae, called striae albae, are common but treatment-resistant dermal scars. Fractional radiofrequency (FRF) can potentially act as transdermal permeation enhancer for topical tretinoin (TT). This study investigated FRF and TT as a combination treatment for stri...