Biotechnology Research Center

A versatile Bacillus esterase reveals a carboxylesterase blueprint for PET intermediate degradation

Abstract The biodegradation of polyethylene terephthalate (PET), and its derived intermediate breakdown products, represents a core focus of multidisciplinary research. While Ideonella sakaiensis PETase (IsPETase) and leaf-compost cutinase (LCC) efficiently depolymerize PET, many...

Postbiotic polysaccharide and peptide-enriched electrospun nanofibers based on polycaprolactone/ethyl cellulose/sodium alginate as bioactive macromolecular matrices for aflatoxin M1 adsorption in milk

Abstract Aflatoxin M1 (AFM1) contamination in dairy products raises many food safety concerns due to its toxicity and resistance to conventional processes. In this study, a novel bio-based adsorption system was developed using electrospun polycaprolactone/ethyl cellulose/sodium a...

Optimizing alginate-based delivery systems to enhance adipose-derived stem cell functionality in regenerative medicine: a comprehensive review

This review explores the potential of alginate-based delivery systems for adipose-derived stem cells (ASCs) in regenerative medicine, with a focus on recent strategies that enhance ASC survival, functionality, and therapeutic efficacy. A structured literature analysis was perform...

A native dairy-derived Streptococcus thermophilus potentiates docetaxel efficacy by modulating apoptotic and PI3K/AKT/mTOR signaling pathways in MCF-7 breast cancer cells

Docetaxel (DTX) is a widely used chemotherapeutic agent for breast cancer; however, its clinical application is limited by dose-dependent toxicity and chemoresistance. This study investigated the chemosensitizing potential of a native dairy-derived S. thermophilus strain in combi...

RNA-guided transposases: the successors to CRISPR

CRISPR undoubtedly transformed genome editing, but it left two crucial problems unsolved. Cas nucleases cut the chromosome and leave the cell to repair the break, an error-prone process that is inefficient for installing new DNA, and Cas9 is large relative to the cargo that viral...

Expression patterns of miR-429/FN1 and miR-592/TOP2A in breast cancer: Clinicopathological correlations and diagnostic value

Breast cancer remains the most common cancer and a leading cause of cancer-related mortality among women worldwide. Identifying reliable biomarkers is essential for improving disease diagnosis and outcomes. This study aimed to evaluate the expression levels of miR-429 and miR-592...

Context dependent roles of MicroRNA-377 in cancer from epigenetic silencing to therapeutic reactivation

MicroRNA-377 (miR-377) is a predominantly tumor-suppressive microRNA with context-dependent functions in cancer. Located within the imprinted DLK1-DIO3 region on chromosome 14q32, miR-377 regulates proliferation, apoptosis, invasion, metastasis, and treatment response, and its dy...

Engineering copper ferrite (CuFe2O4) nanosystems for medicine: a comprehensive review from design to biomedical applications

Abstract Biomedical micro/nanosystems are rapidly advancing toward integration of therapeutic and diagnostic nanoscale agents into unified platforms. Engineers still struggle to precisely control multiple functions in biocompatible designs. Copper ferrite (CuFe 2 O 4 ) nanopartic...

Antibacterial evaluation of sophoraflavanone G from Sophora pachycarpa against Pseudomonas aeruginosa and Staphylococcus epidermidis biofilm

Abstract Antimicrobial resistance, particularly among biofilm-forming pathogens, poses a serious threat to public health and drives the urgent need for new therapeutic agents. Sophoraflavanone G, a prenylated flavonoid derived from Sophora pachycarpa , has shown notable antimicro...

Microbial Ecological Damping: A Multilevel Systems-Ecology Framework for Climate–Biodiversity Resilience

Climate change and biodiversity loss alter disturbance regimes, yet resilience frameworks often underresolve the microbial infrastructure through which disturbance is attenuated, transmitted, reorganized, or amplified. This Perspective analyzes that infrastructure across three di...

From Conatus to the War of Nature: Scarcity, Scientific Metaphors, and the Epistemic Rewriting of Biological Persistence

Biological persistence is both a biological and an epistemic problem: vocabularies of scarcity, struggle, competition, war, and survival make some dimensions of continuation especially easy to describe while leaving others less direct to articulate. This article reconstructs diff...

From Conatus to the War of Nature: Scarcity, Scientific Metaphors, and the Epistemic Rewriting of Biological Persistence

Biological persistence is both a biological and an epistemic problem: vocabularies of scarcity, struggle, competition, war, and survival make some dimensions of continuation especially easy to describe while leaving others less direct to articulate. This article reconstructs diff...