Bioscience (China)

ZCCHC4 promotes replication-dependent histone mRNA translation through interaction with the eIF3 complex

Abstract Histone synthesis is tightly coupled with DNA replication to ensure proper chromatin assembly and genome stability. To meet the sharply elevated demand for histones during S phase, eukaryotic cells employ specialized mechanisms to translate replication-dependent (RD) his...

Early life sugar rationing and ageing related diseases, biological ageing and mortality

Early-life nutrition may influence lifelong ageing, yet human evidence is scarce. Using Britain’s postwar sugar rationing as a natural experiment, we examine its long-term effects in 64,809 United Kingdom Biobank participants. Exposure to sugar rationing during the first 1,000 da...