Bethel University

Deep whole genome sequencing of epileptogenic brain lesions

Abstract Objective Malformations of cortical development and low‐grade epilepsy‐associated tumors often cause drug‐resistant lesional focal epilepsy (LFE) amenable to surgical treatment. Genetic testing of resected brain tissue can provide diagnostic and mechanistic information a...

Intellectual humility and eudaimonic well-being among emerging religious/spiritual leaders

Religious/spiritual leaders remain an understudied at-risk population for lower eudaimonic well-being. We explored the potential for intellectual humility to promote greater eudaimonia with divine struggles as a mediator. We used a diverse sample of leaders obtaining graduate the...

Diagnosing autoimmune encephalitis in psychiatry: clinical recommendations and unresolved challenges from the GENERATE network

Psychiatric syndromes can be caused by underlying autoimmune encephalitis (AE). This represents a diagnostic challenge at the interface of psychiatry and neurology. While AE mostly manifests with a combined, complex neuropsychiatric syndrome, some patients with AE may (initially)...

Parvovirus B19 infections in paediatric sickle cell disease patients: Genotype and hydroxyurea treatment influence disease severity

Summary In patients with sickle cell disease (SCD), parvovirus B19 infection (B19V) leads to acute anaemia (aplastic crisis), but may also be associated with other serious complications. We retrospectively analysed clinical data from paediatric SCD patients with B19V infections b...

Post-traumatic stress disorder following intensive care for COVID-19: a single-center retrospective follow-up study

Abstract Background Severe COVID-19 frequently required prolonged intensive care, including mechanical ventilation or extracorporeal membrane oxygenation (ECMO). Survivors of such critical illness may develop post-traumatic stress disorder (PTSD). Methods We conducted a single-ce...

Everyday physical activity, exercise and perceived fitness in patients with difficult-to-treat epilepsy and/or functional/dissociative seizures: development of instruments and single-center experience

OBJECTIVE: To develop questionnaires assessing physical activity (PA) across life domains, exercise and perceived fitness that are suitable for patients with difficult-to-treat epilepsy and/or functional/dissociative seizures (FDS), explore their psychometric properties, and exam...

Revising the Cornerstones of Public Health Nursing for Global Relevance

ABSTRACT Background The Cornerstones of Public Health Nursing encompass the values and beliefs foundational to public health nursing practice. A comparison of the original Cornerstones, developed more than 20 years ago, with recent revisions of nursing ethical guidelines led to a...

Process evaluation of the randomized trial—“Care management for older people with cognitive impairment during and after hospitalisation in Germany (intersec-CM)”

Abstract Background Effective care of people with cognitive impairment and their families depends, among other things, on the cooperation of the professionals involved in their care. An effective dementia care management support model for people with dementia and their families f...

Shifting AAV9 tropism by binding moiety insertion enhances transduction of tumor cell lines and human glioblastoma explants

Abstract Tumor-specific targeting remains a major obstacle for the development of precision cancer therapies. For several tumors and specifically glioblastoma (GBM), an aggressive brain tumor with poor prognosis, more effective treatments are urgently needed. Recombinant adeno-as...

High-frequency visual stimulation can increase medial temporal lobe ripple oscillation density

Abstract Background Flickering visual stimulation can evoke neural oscillations, which can influence ongoing brain activity. Electrophysiological recordings of neural oscillations in the ripple band (80–180 Hz) show that these high-frequency oscillations occur in the neocortex an...

Ruling In and Ruling Out Sepsis Using Likelihood Ratios of a Host Response Assay

Overview: SeptiCyte RAPID is an FDA-cleared gene expression test that quantifies host immune response to aid in the diagnosis of sepsis. The test yields a score (the SeptiScore) ranging from 0–15, distributed across four bands (1–4) based on increased likelihood of sepsis. Each b...