Berlin Institute of Health at Charité - Universitätsmedizin Berlin

Best subset selection meets resampling: tackling selection instability at very low numbers of events per variable

Abstract Trust is a basic necessity for translating machine learning models from bench to bedside. To foster clinicians’ trust in predictive models, these models should be interpretable or explainable. A major prerequisite for interpretability or explainability is that feature su...

Effects of secondary factor VIII prophylaxis on joint and bone health in a hemophilia A mouse model

Not available.

TCR sensitivity shapes recognition of tumor antigen presented by host cells and TCR-T cell efficacy in solid tumors

Despite advances in adoptive T cell therapy, therapeutic efficacy in solid tumors remains inconsistent, and the mechanistic determinants of treatment failure are incompletely understood. Increasing evidence suggests that effective antitumor responses depend not only on direct rec...

Longitudinal Functional Magnetic Resonance Imaging to Assess Lung Disease in Cystic Fibrosis

Abstract Rationale Matrix pencil decomposition magnetic resonance imaging (MP-MRI) enables quantitative assessment of lung ventilation and perfusion and was shown to correlate with contrast-enhanced (CE) perfusion MRI. Objectives To determine the longitudinal course of MP-MRI par...

Towards data-driven refinement of an automated cluster alert system: assessing the concordance of epidemiological expert assessment and genotyping

Abstract Objective: An automated CLuster AleRt system (CLAR) is employed at our hospital to detect clusters of relevant microorganisms. Alerts are subsequently assessed by infection prevention and control (IPC) experts to determine their epidemiological relevance. This study comp...

Is There an Association Between Preoperative PONV Prophylaxis With Dexamethasone and Incidence of Wound Revisions in the Surgical Treatment of Pediatric Secondary Scoliosis? A Retrospective Cross-Sectional Study in 162 Patients

BACKGROUND DATA: Pediatric patients undergoing surgery for secondary scoliosis are at special risk for surgical site infections (SSIs). The application of dexamethasone (Dexa) for perioperative prophylaxis of postoperative nausea and vomiting is an established method. Despite the...

Workshop: Introduction to Systematic Review & Meta-Analysis of Animal Studies

Materials associated with our workshop "Introduction to Systematic Review & Meta-Analysis of Animal Studies". In this workshop you will learn the key steps required to conduct a systematic review and meta-analysis of preclinical animal studies. Until further notice, this is an on...

A global sagittal deviation index (GSDI-5) incorporating upper cervical alignment: initial construct validation in forward head posture

Abstract Purpose Forward head posture (FHP) is commonly assessed using isolated cervical measures, potentially overlooking its relationship with global sagittal alignment. This study introduces the Global Sagittal Deviation Index (GSDI-5), a composite measure integrating multireg...

Pre-ECMO characteristics, organ dysfunction and exploratory mortality prediction in COVID-19 versus non-COVID-19 ARDS treated with veno-venous ECMO: a retrospective cohort study

Abstract Objective The transferability of pre-ECMO characteristics and established mortality prediction tools across COVID-19 (C-19) and non-COVID-19 (nC-19) acute respiratory distress syndrome (ARDS) remains uncertain. We compared clinical characteristics, organ dysfunction, res...

Using multi-trait polygenic scores to predict lithium responsiveness in patients with bipolar disorder

Background The predictive power of polygenic scores (PGSs) for lithium treatment response in bipolar disorder remains limited. Aims To enhance the prediction of lithium responsiveness by developing a multi-trait PGS (mt-PGS) combining genetic information from multiple phenotypes...

Proteome signatures in ICU patients with COVID-19 and acute brain dysfunction: an observational cohort study

Abstract Deep sedation and delirium are common in COVID-19 intensive care unit (ICU) patients. Biomarkers for prediction, detection, and monitoring are missing. Unbiased omics analyses are warranted to gain a systems biology view on pathophysiology. This prospective observational...

A multimodal manual therapy, exercise, and psychological intervention for painful diabetic neuropathy: the NeuOst feasibility randomised controlled trial.

Introduction: People with painful diabetic neuropathy lack effective and tolerable treatments. Physical and psychological interventions may help but require further study and combination to maximise effects. Objectives: This single-site, 3-arm, parallel, randomised feasibility tr...

CADD-ThresholdApp: an interactive web application for calibrating CADD scores using ClinVar

Abstract Background The Combined Annotation Dependent Depletion (CADD) score is one of the most widely used genome-wide variant deleteriousness scores. In practice, however, the distribution of CADD scores differs across genes and gene sets and may also vary between genome builds...

Real-world use of bempedoic acid for hypercholesterolaemia: a German multicentre, retrospective, cohort study

Abstract Background Dyslipidaemia remains a leading cause of death in Germany despite an improving therapeutic landscape, with many patients not achieving guideline-recommended low-density lipoprotein cholesterol (LDL-C) goals. Bempedoic acid, an adenosine triphosphate citrate ly...

How ethics operationalization breaks down in practice: expert perspectives from healthcare AI

Abstract Efforts to promote “Trustworthy AI” have focused on operationalizing high-level ethical principles through tools, standards, and governance mechanisms. Yet a persistent gap remains between ethical guidance and day-to-day development practice. We conducted semi-structured...

Diving deep into uterine layers: ADC and IVIM at 0.55-T MRI

Abstract Objective To investigate and analyze the microstructure of uterine layers and to evaluate the feasibility and physiological variability of uterine diffusion metrics at 0.55-T MRI in healthy volunteers and participants with adenomyosis. Materials and methods In this prosp...

Clinical evaluation of AI-assisted quantitative marrow fibrosis assessment using Continuous Indexing of Fibrosis (CIF)

Abstract Assessment of fibrosis is central to the evaluation of diagnostic bone marrow trephine (BMT) biopsies. However, manual fibrosis grading is subjective and only semi-quantitative. We evaluated the clinical utility of a previously developed AI-based quantitative fibrosis as...

Drug Survival of Omalizumab and Factors Associated With Discontinuation in Chronic Urticaria

Importance Omalizumab is a recommended second-line therapy for chronic urticaria (CU), yet clinical evidence regarding long-term drug survival and determinants of discontinuation remains limited. Understanding drug survival patterns may inform clinical decision-making and patient...

Exploring cerebral small vessel disease signatures in familial Parkinson’s disease

Familial Parkinson's disease (PD) and vascular parkinsonism (VP) present overlapping features and may co-exist. To investigate whether PD and VP may share a potential pathogenic link and to what extent white matter hyperintensities may influence PD phenotype, we used the modified...

Vaccine hesitancy beyond borders: a multi-sited study of migrants and non-migrants across Germany and Turkey

Vaccination is a key protective measure against infectious diseases, yet vaccine hesitancy is rising, and coverage remains lower among migrant populations. Research largely attributes gaps to migrants’ characteristics, such as higher religiosity, overlooking broader mechanisms. W...