Berlin Institute of Health at Charité - Universitätsmedizin Berlin

Patient perspectives from the BEYOND Delphi panel: burden of remaining symptoms and their fluctuations, despite treatment, in patients with generalised myasthenia gravis

Abstract Background Patients with generalised myasthenia gravis (gMG) can experience remaining symptoms despite treatment. Our study aimed to describe how remaining symptoms and their fluctuations may affect a person’s daily life while living with gMG. Methods A modified-Delphi p...

Empowering medical educators to teach planetary health: development and outcomes of a curriculum integration training

<title>Abstract</title> <bold>Background</bold> Planetary Health (PH) content is increasingly recognized as essential for medical education. For longitudinal integration across the curriculum, medical educators can serve as change agents and multipliers. A targeted training that...

Quantification of practice effects in a self-administered online cognitive pre-screening test

BACKGROUND: With growing prevalence of mild cognitive impairment and dementia, online self-administered pre-screening tests hold the promise to more objectively identify individuals who stand to benefit from prioritized access to supervised cognitive testing and in-depth neurolog...

Transcranial Electrical Stimulation and Delirium Among Postoperative Patients

Importance Postoperative delirium (POD) occurs as a significant complication after elective surgery. Objective To investigate the modulation of delirium incidence by transcranial electric stimulation (tES). Design, Setting, and Participants A double-blind, sham-controlled randomi...

Comparative analysis of neuronal proteolytic pathways reveals neuron-specific and sub-compartmental-specific capacities with aging

Abstract Proteostasis is essential for maintaining neuronal function, and its dysregulation is a hallmark of aging and neurodegeneration. The ubiquitin-proteasome system (UPS) and macroautophagy are the two major proteolytic pathways responsible for protein degradation. However,...

Implementation barriers, facilitators, and fidelity of a mobile money-based savings tool for pregnant women in the Analamanga region of Madagascar: an ex-post process evaluation

Abstract Background Mobile payment services could improve access to obstetric care by easing saving, raising revenue, and pooling resources. Between 2019 and 2022, a mobile money-based savings tool for obstetric care was implemented in the Analamanga region of Madagascar followin...

Evaluating clinical and neuroimaging predictors for cognitive-behavioral therapy outcome in obsessive-compulsive disorder

Abstract Cognitive-behavioral therapy (CBT) is the first-line treatment for obsessive-compulsive disorder (OCD), yet a significant number of patients do not achieve remission or substantial symptom relief. This study aims to enhance the prediction of CBT outcomes in OCD by integr...

The importance of B cells for osteogenic homeostasis

Abstract Therapeutic interventions for diseases such as leukemia and autoimmune disorders are increasingly designed to selectively target and deplete specific immune cell subsets over prolonged periods. This can disrupt the homeostasis of the adaptive immune system, with conseque...

Reversible epiblast regionalization determines differentiation potential of human pluripotent stem cells

Abstract Although human pluripotent stem cells (hPSCs) can generate all tissues of the body, hPSCs in vitro frequently exhibit differentiation biases or failure that pose substantial challenges for disease modeling and regenerative medicine. The origins of these biases remain inc...

Sagittal alignment patterns in forward head posture: an EOS-based head-to-pelvis correlation analysis

Abstract Study Design Retrospective radiographic study. Objectives Forward head posture (FHP) is commonly observed in individuals with prolonged screen exposure and may affect spinal alignment. Because the craniovertebral angle (CVA) alone does not fully capture how sagittal bala...

A perioperative management elective as a transition-to-practice intervention: effects on preparedness, professional identity, and career decision-making

Abstract Background Perioperative management requires a broad range of knowledge and practical skills essential for early clinical practice, yet perioperative care is often taught in fragmented rather than integrated fashion across undergraduate medical curricula. Beyond technica...

Visible injury patterns in relation to reported sexual acts after sexual assault: a retrospective cohort study

Sexual assault may result in visible anogenital and extragenital injuries, but the absence of such findings remains a major challenge in forensic interpretation. This retrospective forensic outpatient study analyzed 306 adults examined after reported sexual assault at the Violenc...

Identification of unvaccinated children, Madagascar.

Problem: Madagascar has a high number of unvaccinated (zero-dose) children. In 2023, an estimated 74% received any dose of the diphtheria-tetanus-pertussis (DTP) vaccine. In southern Madagascar, service gaps, poverty, drought and limited access leave many children unreached by ro...