Beijing University of Chinese Medicine

A practical nomogram for the early prediction of hemiplegic shoulder pain in stroke patients: a development and validation study

Abstract Objective To facilitate early clinical risk stratification for hemiplegic shoulder pain (HSP) after stroke, this study aimed to identify potential risk factors and develop a predictive nomogram. Methods This retrospective study included 450 inpatients with stroke admitte...

The Lactate–Lactylation Axis as a Metabolic–Epigenetic Framework for Therapeutic Adaptation in Esophageal Squamous Cell Carcinoma

Therapeutic failure in esophageal squamous cell carcinoma (ESCC) can arise as tumor cells and their microenvironment adapt to sustained treatment pressure. The lactate–lactylation axis may connect altered metabolism with adaptive treatment responses through changes in protein and...

M2-associated microglial states in oligodendrocyte regulation and white matter repair in vascular dementia

Vascular dementia (VaD), the second most common form of dementia, lacks approved disease-modifying therapies. White matter injury and demyelination are major pathological features, and oligodendrocyte-lineage damage directly limits myelin repair. M2-associated microglial response...

AIS-defined insomnia symptoms and left atrial diameter index in patients with nonvalvular atrial fibrillation: a multicenter cross-sectional study

Insomnia symptoms may contribute to atrial remodeling, but their association with left atrial structure in established nonvalvular atrial fibrillation remains unclear. We examined whether Athens Insomnia Scale-defined sleep status was associated with body surface area-indexed lef...

Prediction and Planning of Planting for Ecologically Suitable Areas of Cistanche deserticola Using MaxEnt

This study aimed to predict potentially suitable areas for Cistanche deserticola in China and to provide a scientific basis for its cultivation layout and production planning. Based on the MaxEnt algorithm and ArcGIS spatial analysis, two independent ecological niche models were...

From TCM–conventional medicine combination to integration: the driving role of evidence-based research

From TCM-conventional medicine combination to integration: the driving role of evidence-based research.

How can traditional Chinese medicine trials achieve global credibility

Abstract Traditional Chinese medicine (TCM) needs credible evidence that meets international evidence-based medicine standards to achieve global credibility and acceptance. A fundamental and crucial task is to conduct high-quality randomized controlled trials (RCTs). To achieve g...

DFGLM-TCM: an integrated knowledge-and experience-driven large language model system for Traditional Chinese Medicine practice

Abstract Traditional Chinese Medicine (TCM) clinical practice depends on both codified theoretical knowledge and practitioner-specific experience, which differ in their data sources, reasoning patterns, and scope of generalization. We developed DFGLM-TCM, a modular large language...

Efficacy and Safety Assessment of Upadacitinib for SAPHO Syndrome: A Retrospective Study of 35 Patients

OBJECTIVE: This study aimed to evaluate the efficacy and safety of upadacitinib administered over a short-term period in patients with SAPHO syndrome. METHODS: In this 12-week retrospective observational study, eligible SAPHO syndrome patients diagnosed within the past year and t...

Assessing traditional Chinese medicine service quality from physicians’ perspectives: a nationwide survey in China

Service quality is important for strengthening traditional Chinese medicine (TCM) within contemporary healthcare systems, yet provider-based evidence remains limited, particularly for TCM-specific aspects of clinical practice. We conducted a cross-sectional online survey of physi...

Development and internal validation of a machine learning-based clinical prediction model for liver metastasis in stage III–IV non-small cell lung cancer

Liver metastasis is among the major determinants of prognosis in non-small cell lung cancer (NSCLC), and early identification of high-risk patients has direct implications for clinical management. We retrospectively enrolled 849 patients with stage III–IV NSCLC and split them 8:2...

Comparative effectiveness of dietary supplements in dilated cardiomyopathy: a systematic review and network meta-analysis

Abstract Background Dilated cardiomyopathy (DCM) is a major cause of heart failure and cardiovascular mortality, partly due to impaired myocardial energy metabolism. Dietary supplements may offer benefits through improved mitochondrial function and antioxidant effects, and random...

Resinous traditional Chinese medicine for cancer treatment: Mechanisms and therapeutic potential

Abstract Resinous traditional Chinese medicines are a ‘treasure trove of natural bioactive molecules’. Their unique hydrophobic components are an important source of antitumour agents. Resinous traditional Chinese medicines, including frankincense, myrrh, gamboge, Sanguis Draconi...

Characterizing Shared Sensory Priorities and Age-Group Differences for Feng-Flavor Baijiu: A Consumer Survey Using Hierarchical Weighting and Interpretable Machine Learning

As Feng-flavor Baijiu increasingly shifts toward consumer-oriented product development, clarifying consumers’ shared sensory priorities and age-related differences is essential for aligning its traditional style with evolving market demands. This study collected 1523 questionnair...

Risk factors and prevalence of incontinence-associated dermatitis in elderly patients: a meta-analysis and systematic review

This systematic review aimed to evaluate the prevalence and risk factors of Incontinence-Associated Dermatitis (IAD) in elderly patients. A systematic search was conducted across 10 databases, including PubMed, Embase, Web of Science, Cochrane Library, CINAHL, Ovid MEDLINE, Scopu...

Maxing Loushi Decoction alleviates COPD by targeting the PD-1/PD-L1 pathway: restoring Th17/Treg balance and inhibiting ferroptosis

Chronic obstructive pulmonary disease (COPD) is a progressive respiratory disorder driven by immune dysregulation and ferroptosis, with limited therapies addressing its underlying pathogenesis. Maxing Loushi Decoction (MXLS), a modified traditional Chinese medicine (TCM) formula,...

Preclinical evidence of neuroprotective effects of endocannabinoids and related lipid molecules in ischemic stroke: a systematic review and meta-analysis of animal studies

Background Ischemic stroke is an acute cerebrovascular disorder caused by interruption of cerebral blood supply, frequently resulting in severe neurological deficits. However, effective therapeutic strategies remain limited. Recent studies have demonstrated that endocannabinoids...

Inadequate Reporting of Harms in RCTs of Chinese Herbal Medicine Formulas: A Systematic Survey of Leading Medical Journals

ABSTRACT Objective To evaluate harms reporting practices in placebo‐controlled randomized clinical trials (RCTs) of Chinese herbal medicine (CHM) formulas published in Quartile 1 (Q1) English‐language and Tier‐1 Chinese journals. Methods This systematic survey evaluated harms rep...

Metabolic-extracellular matrix crosstalk in hepatocellular carcinoma: mechanisms and targeted intervention

Bidirectional crosstalk between metabolic reprogramming and extracellular matrix (ECM) remodeling in hepatocellular carcinoma (HCC) constitutes an important metabolic–ECM regulatory network that contributes to HCC progression. Metabolic derangements disrupt ECM deposition, crossl...

Domino Effect in Epimer Self‐Assembly Induces Diverse Hydrogel Properties for Biomedical Applications

ABSTRACT Precise regulation of small‐molecule self‐assembly remains a formidable challenge, as subtle structural variations can trigger profound reprogramming of supramolecular architectures. Herein, we demonstrate that C18‐epimerization of glycyrrhizic acid (GA) acts as a molecu...