Beijing Tongren Hospital

Endoscopic Endonasal Approach to the Medial Aspect of the Temporomandibular Joint Region

ABSTRACT Background The temporomandibular joint (TMJ) region is the most superolateral aspect of exposure via an endonasal corridor, while studies regarding the endonasal approach to this specific region are lacking. This study aimed to provide a detailed step‐by‐step surgical te...

Infraorbital Skin Application of Menthol Emulsion for Dry Eye Disease: A Randomized Clinical Trial

We aim to evaluate the short-latency tear-secretory effects and symptom responses of infraorbital menthol emulsion in dry eye disease (DED) without intentional ocular-surface instillation. In this randomized, participant- and assessor-masked, vehicle-controlled trial, 128 adults...

Three-year outcomes of combined surgical peripheral iridectomy, goniosynechialysis and goniotomy for advanced primary angle-closure glaucoma: a multicentre study

Aims To assess the 3-year efficacy and safety of combined surgical peripheral iridectomy (SPI), goniosynechialysis (GSL) and goniotomy (GT) for advanced primary angle-closure glaucoma (PACG) without cataract. Methods This was a multicentre prospective observational study with ext...

Association of depressive symptoms with retinal layer thickness: insights from the population-based Beijing eye study 2011

The aim of this study is to investigate the association between depressive symptoms and retinal layer thickness in a population-based adult Chinese cohort. This population-based, cross-sectional study included 2127 eyes of 2127 participants of Beijing Eye Study 2011, free of any...

Early unilateral VZV-associated acute retinal necrosis misdiagnosed as iridocyclitis: a case report

Abstract Purpose To report a case of early unilateral VZV-associated acute retinal necrosis (ARN) which was initially misdiagnosed as iridocyclitis and progressed to retinal detachment. Case presentation A 41-year-old female patient presented with two weeks of blurry vision in th...

Protocol for measuring above-threshold ionization spectra driven by few-cycle laser pulses in frustrated tunneling ionization regime

Above-threshold ionization (ATI) spectra in the frustrated tunneling ionization (FTI) regime demonstrate control of bound-state populations via the carrier-envelope phase (CEP). Here, we present a protocol for acquiring ATI spectra from argon gas driven by few-cycle laser pulses....

School-based hygiene intervention to prevent Helicobacter Pylori infection among children (SHIP HOPE): a cluster-randomized controlled trial

Helicobacter pylori ( H. pylori ) is a major cause of gastric cancer and is typically acquired during childhood. Preventing infection in uninfected children is a promising strategy; however, the effectiveness of hygiene-based interventions remains uncertain. This study aimed to d...

The “Five in One” integrated precise prevention and control system for pollen allergic diseases in Northern China: A narrative review with global perspective

Allergic diseases driven by airborne pollen are a growing public health burden in Northern China, where spring tree pollens and summer–autumn weed pollens are major triggers of allergic rhinitis, asthma, conjunctivitis, atopic dermatitis, and anaphylaxis. Internationally, managem...

Retinal Vascular Caliber and Its Ocular and Systemic Correlates in Children Living at High Altitude

Background/Objectives: The retina is a highly metabolically active tissue that depends on precise vascular regulation. Childhood represents a critical period of ocular growth, and retinal vascular characteristics may provide insights into the relationship between microvascular de...

Analysis of hematologic toxicity profiles following CAR-T cell therapy: a retrospective cohort study

Abstract Background Chimeric antigen receptor (CAR) T-cell therapy has transformed the treatment of relapsed/refractory (R/R) B-cell malignancies, most notably large B-cell lymphoma. However, hematologic toxicity—recently formalized as immune effector cell-associated hematotoxici...

Multisite Extraocular Dryness is Associated with Symptomatic Dry Eye and Tear-Film Instability Among Adults Without Severe Meibomian Gland Loss

PURPOSE: To evaluate whether a greater number of self-reported extraocular dryness sites is associated with Ocular Surface Disease Index (OSDI)-defined symptomatic dry eye and non-invasive tear break-up time (NIBUT)-defined tear-film instability among community-dwelling adults wi...

Stapokibart efficacy by asthma status in chronic rhinosinusitis with nasal polyps: a post hoc analysis of the CROWNS-2 trial

Background: Asthma is a common comorbidity in patients with chronic rhinosinusitis with nasal polyps (CRSwNP). Stapokibart, a novel anti-interleukin-4 receptor alpha monoclonal antibody, demonstrated efficacy and safety in patients with CRSwNP in a phase 3 trial (NCT05436275). Ob...

An oral coral-like resveratrol nanocomplex protects against dry eye disease through ocular and systemic redox homeostasis

Dry eye disease (DED) is a progressive ocular disorder in which chronic inflammation and oxidative stress synergistically damage ocular tissues and impair vision. While topical anti-inflammatory and artificial tears therapies are the standard treatment for DED, their long-term ap...

EIF1 coordinates transcriptomic and splicing networks associated with cell cycle dysregulation in diabetic retinopathy

Purpose EIF1, an RNA-binding protein implicated in multiple diseases, remains poorly characterized in diabetic retinopathy (DR). This study therefore investigated EIF1 expression and function in an in vitro model of DR pathogenesis. Methods Human retinal pigment epithelial cells...

The morphology of optic disc and the thickness of retinal nerve fiber layer in a population of 9-year-old children in North China

Optic disc morphology and retinal nerve fiber layer (RNFL) thickness have been widely studied in populations with refractive error. This study aims to measure and analyze optic disc parameters and RNFL thickness in different regions of the optic disc in 9-year-old schoolchildren....

A Rare De Novo Missense Mutation in IFT122 Confers a Genetic Susceptibility Factor of Idiopathic Pediatric Uveitis Via Trio‐based Whole‐Exome Sequencing

ABSTRACT Idiopathic pediatric uveitis (IPU) is a leading cause of irreversible vision loss in children; however, the genetic and molecular mechanisms underlying this condition remain unclear. Herein, trio‐based whole‐exome sequencing was performed in 28 affected families and targ...

Digital Defocus Vision Training Using Virtual Reality for Myopia Control

Importance Virtual reality–based digital defocus vision training (DDVT) may offer a home-based strategy to slow myopia progression in children, but evidence is limited. Objective To evaluate efficacy and safety of a head-mounted virtual reality–based DDVT system on myopia progres...

Efficacy, safety, and pharmacokinetics of pumecitinib nasal spray for moderate-to-severe seasonal allergic rhinitis: a multicentre, double-blind, randomised, placebo-controlled, phase 2 trial

Background Seasonal allergic rhinitis (SAR) is a pollen-triggered condition causing nasal inflammation and quality of life impairment. Pumecitinib, a topical Janus kinase (JAK) inhibitor may modulate allergic inflammation. We evaluated the efficacy, safety, and pharmacokinetics o...

Uncertainty-inspired open-set model for identifying infantile fundus abnormalities

Accurate and safe identification of infantile fundus abnormalities is critical for large-scale screening, yet remains challenging because of heterogeneous disease presentations and overconfident predictions by conventional artificial intelligence (AI) models. In this study, we ai...

Aqueous Humor Proteomics Reveals the Molecular Basis for Differential Treatment Responses in nAMD and pmCNV

Purpose: Choroidal neovascularization (CNV) causes vision loss in neovascular age-related macular degeneration (nAMD) and pathologic myopia-related CNV (pmCNV). Despite shared clinical features, they respond differently to treatment. This study compared aqueous humor (AH) proteom...