Beijing Friendship Hospital

Serum brain-derived neurotrophic factor is associated with diabetic complications and glycemic control in type 2 diabetes: an exploratory analysis of the ADNI cohort

To investigate the association between serum brain-derived neurotrophic factor (BDNF) levels and the clinical profile as well as complications in patients with type 2 diabetes mellitus (T2DM). A total of 185 participants were enrolled, including 35 healthy controls, 111 T2DM pati...

Early oseltamivir initiation and influenza outcomes in kidney transplant recipients: a multicenter real-world study

Influenza infection poses a significant clinical threat to kidney transplant recipients due to their immunocompromised status. Although current guidelines recommend early antiviral therapy, real-world evidence supporting the effectiveness of oseltamivir, particularly regarding th...

18F-FDG PET/CT-based Metabolic-clinical prognostic model could refine risk stratification in high-risk neuroblastoma

The prognosis of high-risk neuroblastoma (NB) is highly heterogeneous, underscoring the necessity of refining risk stratification to guide precision treatment and improve outcomes. The aim of this study was to construct an 18 F-FDG PET/CT-based Metabolic-clinical prognostic model...

Microbiota and inflammatory factor profiles in different stages of bacterial vaginosis formation and recurrence

Introduction. Bacterial vaginosis (BV) is a common gynaecological disorder characterized by an imbalance in the vaginal microbiota, leading to increased risk of infection and recurrence. Hypothesis/Gap statement. Although the role of microbiota dysbiosis in BV is established, the...

Association between living environmental quality and risk of gastrointestinal diseases among middle-aged and older adults: evidence from a national study

Abstract Background With the rapid progression of population aging in China, gastrointestinal (GI) diseases have become one of the most common chronic conditions among middle-aged and older adults, substantially impairing quality of life and increasing healthcare burdens. However...

FGFR3-driven gene regulatory network analysis reveals a protumoral role for p63 in luminal bladder tumors

Fibroblast growth factor receptor 3 ( FGFR3 ) is one of the most frequently altered genes in bladder cancer, primarily through activating mutations that drive oncogenesis and are enriched in luminal tumors. However, the underlying gene regulatory network (GRN) remains poorly char...

Serum homocysteine as a novel biomarker for predicting intestinal necrosis in patients with bowel obstruction: a prospective observational study

We evaluated the diagnostic accuracy of serum homocysteine (HCY) for predicting intestinal necrosis in patients with bowel obstruction and compared its performance with conventional inflammatory biomarkers. This prospective observational study enrolled consecutive patients presen...