Beijing Friendship Hospital

AGDE-Net: a lightweight attention-guided dual-encoder network for tumor core and peritumoral edema segmentation in adult glioma

Abstract Background Glioma is a malignant primary brain tumor arising from glial cells, often resulting in fatal outcomes without timely treatment. Accurate and reliable tumor segmentation is essential for clinical decision-making and therapeutic evaluation. This study aims to de...

Curcumin Enhances the Sensitivity of 5-fluorouracil-resistant Colon Cancer Cells to 5-fluorouracil Through a Ferroptosis-related Mechanism: A Network Pharmacology and In Vitro Study

Background Colorectal cancer (CRC) is a common and deadly malignancy. Although 5-fluorouracil (5-FU) continues to be a standard therapeutic agent for CRC, the development of resistance substantially compromises its clinical effectiveness. Curcumin, a natural polyphenol, has shown...

Remote‐Controlled Genetic Circuits: Light, Ultrasound, and Magnetic Fields for Programmable Gene Regulation

Remote-controlled genetic circuits use externally applied physical signals to regulate gene expression and cellular functions with spatial and temporal precision. Light, ultrasound, and magnetic fields provide complementary advantages in controllability, tissue accessibility, and...

Elevated Blood Pressure Is Causally Associated With Larger Subcortical Gray Matter Structure Through Perivascular Clearance Routes

ABSTRACT Background This study aimed to investigate the association between elevated blood pressure (BP) and subcortical gray matter structures, and to elucidate the causality and underlying mechanisms. Methods This study enrolled 1012 participants from a multicenter, population‐...

Convolutional neural network for red blood cell transfusion prediction: A machine learning based study

Abstract Background Subjective, inconsistent clinician judgement on red blood cell (RBC) transfusion demand causes unnecessary blood wastage, increased perioperative safety risks, and poorly balanced hospital blood inventory. To tackle these persistent clinical limitations, we de...

Exploratory thyroid ultrasound–computed tomography synthesis using anatomy-preserving contrastive unpaired translation

OBJECTIVES: When ultrasound (US) and computed tomography (CT) are both clinically indicated, unpaired image translation may support model development but cannot replace either examination. We evaluated Anatomy-Preserving Contrastive Unpaired Translation (AP-CUT), a CUT-based fram...

Bisphenol F induces intestinal epithelial injury through hsa_circ_0003655-mediated dual-axis disruption of cytoplasmic and organellar calcium homeostasis

As a primary substitute for bisphenol A (BPA), the potential threats of environmental exposure to bisphenol F (BPF) on intestinal health have raised significant concerns. However, the underlying regulatory mechanisms involving circular RNA (circRNA) remain unclear. Utilizing whol...

Effects of combined training on inflammatory biomarkers in middle-aged and older adults: a systematic review and meta-analysis

Chronic low-grade inflammation is a key factor in aging and age-related diseases. With population aging, effective anti-inflammatory interventions were increasingly needed. Combined aerobic and resistance training (CART) has emerged as a promising non-pharmacological approach; ho...

A computational framework for 3D statistical shape modeling of adult Chinese, Indian, and Malay craniofacial structures from CT imaging

Background and objective Three-dimensional statistical shape modeling provides a computational method to quantify anatomical variation from medical imaging. This study aimed to construct statistical shape models of adult Asian craniofacial structures using computed tomography dat...

Etiological characteristics and genotypes of Mycoplasma pneumoniae infection in children in Baoding from 2022 to 2024

ABSTRACT To investigate the epidemiology associated with genetic types and macrolide resistance of Mycoplasma pneumoniae (MP) in children during and post-COVID-19 in Baoding. A retrospective analysis was conducted on 13,534 children and adolescents (≤18 years old) with community-...

Texture similarity network uncover schizophrenia subtypes with unique molecular signatures

Abstract Schizophrenia manifests complex heterogeneity across multiple dimensions, posing major challenges for precise diagnosis and treatment. Developing objective biomarkers to stratify patients into stable subtypes is essential for heterogeneity resolving and precision medicin...

Predictors of radiation exposure in percutaneous transhepatic cholangiodrainage: a multifactorial analysis integrating fluoroscopy time, cumulative dose, and dose-area product

This study aims to delineate the predictors influencing three complementary radiation metrics—fluoroscopy time (FT), cumulative dose (CD), and dose-area product (DAP)—during percutaneous transhepatic cholangiodrainage (PTCD) to inform targeted radiation safety protocols. We retro...

Spinopelvic alignment changes after unilateral total knee arthroplasty associated with functional recovery

Abstract Background The biomechanical interaction between knee pathology and spine–pelvis alignment in advanced knee osteoarthritis (KOA) has received increasing attention. This study evaluated short-term changes in spinopelvic alignment after unilateral total knee arthroplasty (...

Unveiling the Diagnostic Value and Potential Therapeutic Targets of Phenylalanine Metabolism in Pancreatic Cancer via Integrated Multi‐Omics and Machine Learning

ABSTRACT Pancreatic cancer (PC) presents a significant global health challenge because of its high mortality rate, highlighting the urgent requirement for effective early diagnostic and therapeutic strategies. This study examined the function of phenylalanine metabolism in PC and...

Water hardness and all-cause and cause-specific mortality: evidence from a prospective cohort study

The health implications of domestic water hardness remain controversial, with limited prospective evidence on cause-specific mortality. We investigated associations of calcium carbonate (CaCO 3 ), calcium (Ca), and magnesium (Mg) concentrations with all-cause and cause-specific m...

Olig2 downregulation mitigates early neurological deficits by modulating mitochondrial dynamics in neonatal hypoxic-ischemic brain injury

OBJECTIVE: Mitochondrial dysfunction and apoptosis are key pathological events in neonatal hypoxic-ischemic brain damage (HIBD). Oligodendrocyte transcription factor 2 (Olig2) is upregulated during the early phase of hypoxic-ischemic brain injury. This study aimed to investigate...

Assessing quality in minimally invasive D2 lymphadenectomy: from technical difficulty to AI-enabled audit

Minimally invasive D2 lymphadenectomy for gastric cancer is technically demanding, and its quality varies across patients, surgeons, platforms, and institutions. Conventional endpoints, including lymph node yield, margin status, operative time, blood loss, postoperative morbidity...

WHR and adverse health outcomes: a prospective study on cancer incidence, all-cause and cancer-specific mortality

Obesity is a significant global public health issue, traditionally linked to adverse health outcomes. However, the “obesity paradox” suggests that in certain populations, obesity may be associated with better prognosis. This study investigates the relationship between waist-to-hi...

Efficacy and Safety of Recibokibart, an Interleukin-36 Receptor Antibody, in Generalized Pustular Psoriasis: A Phase 2 Randomized Trial

BACKGROUND: Generalized pustular psoriasis (GPP) is a rare, severe inflammatory skin disease characterized by acute flares. Recibokibart is a humanized IgG1 monoclonal antibody targeting the interleukin-36 (IL-36) receptor. In a phase 1b open-label study, a single intravenous dos...

Association of malnutrition with prognosis in patients with acute myocardial infarction undergoing percutaneous coronary intervention and standard modifiable cardiovascular risk factors

The Nutritional Risk Index (NRI) is a validated clinical instrument for evaluating nutritional status and predicting prognosis across a range of chronic diseases. This study aimed to assess the relationship between the NRI, standard modifiable cardiovascular risk factors (SMuRFs)...