Behavioral Pharma (United States)

The Cost-Of-Living Crisis and Suicide Rates

Abstract: Background: The cost-of-living crisis may be contributing to suicide rates, but this has not been adequately tested. Aims: We aimed to determine whether the cost-of-living crisis is associated with suicide rates in multiple countries and areas-within-countries. Method:...

Distinct acute and chronic brain health phenotypes among people living with HIV in a Ugandan clinical cohort: a comorbidity network analysis

Background: Individual brain health conditions among people living with HIV in sub-Saharan Africa are increasingly well documented, but the co-occurrence of comorbidity and multimorbidity across distinct neurological and psychiatric conditions remains poorly characterized in this...

A glial perspective on the neuropsychiatric effects of cannabis in adolescence and aging

Cannabis use is increasing across a broad range of ages as legal access and social acceptance continue to expand. Its neurobiological effects, however, are unlikely to be uniform across the lifespan. Adolescent cannabis use is associated with later psychiatric and neurocognitive...

Sex-modulated associations between cytomegalovirus cell-associated DNA and cognition in people with HIV on ART

Background: People with HIV (PWH) remain at risk for cognitive impairment, despite effective antiretroviral therapy (ART), a phenomenon linked to chronic immune activation and inflammation. Cytomegalovirus (CMV) has been implicated in HIV-associated neurocognitive impairment, but...

Pilot study comparing the effects of high dose THC to high dose psilocybin and placebo in the set and setting of a classic psychedelic therapy session

RATIONALE: Delta-9-tetrahydrocannabinol (Δ9-THC) has been reported to evoke psychedelic-like experiences at high doses in some individuals. However, the doses of Δ9-THC that occasion such effects and the phenomenology of these experiences are poorly understood. OBJECTIVES: This b...