Bakırköy Dr.Sadi Konuk Eğitim ve Araştırma Hastanesi

Consent architecture in biobanking: ethical attitudes and consent preferences among people with cancer and caregivers

Ethical and socially accountable biobanking depends on public trust and informed consent. Understanding how people with cancer and caregivers view biospecimen use is essential for designing consent models that respect autonomy and reflect cultural values. This study examined cons...

Predictors of One-Year Restenosis After Percutaneous Mitral Balloon Valvuloplasty in Rheumatic Mitral Stenosis: Real-World Data From 555 Patients and the Limited Impact of Periinterventional Transesophageal Echocardiography

OBJECTIVE: Mitral balloon valvuloplasty remains an established first-line treatment for appropriately selected patients with rheumatic mitral stenosis. However, predictors of long-term restenosis and the additional value of periinterventional transesophageal echocardiography rema...

Early versus late therapeutic plasma exchange in sepsis and septic shock

Sepsis involves dynamic inflammatory and endothelial responses, and the timing of extracorporeal therapies such as therapeutic plasma exchange (TPE) may influence clinical outcomes. However, the optimal timing of TPE remains unclear. This retrospective single-center observational...

Early on-pump coronary artery bypass grafting after clinically stable non-ST-segment elevation myocardial infarction with recent clopidogrel exposure versus elective surgery: a propensity score-matched cohort study

Optimal timing of coronary artery bypass grafting (CABG) after non-ST-segment elevation myocardial infarction (NSTEMI) and perioperative management of recent clopidogrel exposure remain related but distinct clinical issues. We compared a selected, clinically stable NSTEMI early-C...

Clinical Utility of the Atherogenic Plasma Index for Identifying Atherogenic Dyslipidemia: A Large Cross-Sectional Analysis Stratified by Sex and Thyroid Status

Background: The atherogenic plasma index (AIP) has emerged as a promising marker reflecting the balance between triglyceride (TG)-rich lipoproteins and high-density lipoprotein cholesterol (HDL-C). However, its clinical utility in identifying atherogenic dyslipidemia (AD), partic...

Comparing clinicopathological factors and quantitative background parenchymal enhancement to predict pathological complete response after neoadjuvant chemotherapy in breast cancer

PURPOSE: To investigate the predictive value of deep learning (nnU-Net)-based fully automated quantitative background parenchymal enhancement (BPE) metrics and clinicopathological factors for pathological complete response (pCR) in patients with breast cancer receiving neoadjuvan...

Association between B-type natriuretic peptide levels and NYHA functional class in older home-care patients with atherosclerotic heart disease: a cross-sectional study

Atherosclerotic heart disease (AHD) is a major contributor to cardiovascular morbidity and may lead to subclinical myocardial dysfunction and eventual heart failure (HF), particularly in elderly populations. B-type natriuretic peptide (BNP) and New York Heart Association (NYHA) f...

Increased choriocapillaris non-perfusion in pediatric hypertension assessed by optical coherence tomography angiography(OCTA)

Abstract Purpose To evaluate retinal microvascular changes in pediatric patients with systemic hypertension compared with healthy controls using optical coherence tomography (OCT) and optical coherence tomography angiography (OCTA). Methods This prospective cross-sectional study...

Shoulder MRI for Forensic Age Estimation: Ossification Staging of the Proximal Humeral Epiphysis

Background/Objectives: Magnetic resonance imaging (MRI) of the proximal humeral epiphysis offers a radiation-free alternative for forensic age estimation in living individuals. This study aimed to characterize the relationship between chronological age and epiphyseal maturation u...

Real-world outcomes of second-line therapy in advanced thymic carcinoma: a multicenter Turkish Oncology Group (TOG) study

Abstract Background Thymic carcinoma (TC) is a rare and aggressive malignancy with limited evidence guiding second-line treatment after prior systemic therapy. We evaluated real-world outcomes of second-line systemic therapy in a multicenter cohort. Methods Adults with unresectab...

Clinicopathological evaluation of crescentic glomerulonephritis: a retrospective single-center study

Abstract Aim Crescentic glomerulonephritis (GN) represents a group of diseases characterized by rapid and severe kidney damage within weeks or months. This study aimed to evaluate the demographic, laboratory, histopathological features, treatment approaches, and renal survival of...

The effect of pulmonary nodule presence on disease severity and course in ANCA-associated vasculitis: a multicenter cohort study

Pulmonary nodules are common in ANCA-associated vasculitis (AAV), but their clinical relevance remains unclear. This study assessed the influence of pulmonary nodules and radiological features on clinical characteristics and outcomes in AAV. In this multicenter retrospective coho...

Serum Asprosin Levels in Patients with Hidradenitis Suppurativa: A Case–Control Study

Background: Hidradenitis suppurativa (HS) is a chronic inflammatory skin disease involving complex interactions between inflammatory and metabolic pathways. Asprosin is a glucogenic adipokine involved in glucose homeostasis, which has been investigated in relation to obesity, ins...

Impact of adjuvant endocrine therapy on disease-free survival in early triple-positive breast cancer: a multicenter retrospective cohort study of the Turkish oncology group

Triple-positive breast cancer (TPBC), characterized by concurrent ER, PR, and HER2 positivity, poses unique therapeutic challenges due to ER–HER2 crosstalk. The optimal adjuvant endocrine therapy in TPBC patients receiving anti-HER2 regimens remains poorly defined. This multicent...