Azienda USL di Bologna

Safety and Efficacy of Acute Normovolemic Hemodilution in Female Patients

Importance Female patients undergoing cardiac surgery have a higher transfusion burden, yet they remain underrepresented in randomized clinical trials. Although the ANH trial showed no significant reduction in the proportion of patients receiving allogeneic blood transfusions wit...

Aggressive PK/PD Target Attainment With Beta-lactams in critically Ill Pediatric Patients Having Suspected or Documented Gram-negative Infections—Prevalence, Risk Factors of Nonattainment and Impact on Clinical Outcome

Objective: To perform a systematic review with meta-analysis for evaluating the prevalence of aggressive beta-lactams pharmacokinetic/pharmacodynamic (PK/PD) target attainment, identifying predictors of aggressive PK/PD target nonattainment, and assessing the impact of attaining...

Real‐World HRR Testing Pathways and Patterns of Detected Alterations in Prostate Cancer From the Multinational ARON‐3 Study

ABSTRACT Background Homologous recombination repair (HRR) testing is increasingly relevant in prostate cancer because it identifies patients who may benefit from biomarker‐guided treatment strategies, including poly(ADP‐ribose) polymerase inhibitors (PARPi). However, real‐world i...

A Descriptive Observational Study of Real-Time TDM-Guided Aggressive PK/PD Target Attainment and Microbiological/Clinical Outcome in Patients with Stenotrophomonas maltophilia Bloodstream Infections and/or Pneumonia Treated with Continuous Infusion Cefiderocol

Objectives: To assess whether attaining an aggressive pharmacokinetic/pharmacodynamic (PK/PD) target with continuous infusion (CI) cefiderocol could be an effective strategy for managing documented bloodstream infections (BSIs) and pneumonia caused by Stenotrophomonas maltophilia...

Benefits and Harms of Herbal Medicines for Preventing and Treating Acute Respiratory Infections: An Overview of Systematic Reviews

ABSTRACT Hundreds of herbal medicines are currently marketed for the management of acute respiratory infections (ARIs). However, there is uncertainty about their benefits and harms, and clinical guidance remains unclear. Our objective was to evaluate the benefits and harms of her...

Risk factors for treatment failure of surgical site deep infections following spinal instrumentation: multicentre observational study (DeFEndO study)

Introduction : To describe the characteristics and outcome of patients diagnosed with deep surgical-site infections following spinal instrumentation (DSIIs) and to investigate risk factors for treatment failure including antimicrobial treatment duration as the main exposure. Mate...

Heart Donation After Controlled Circulatory Death in Noncardiac Surgery Hospitals With a Mobile Heart Team: A Case Series From an Italian Regional Program and Integrated Review of the Literature

ABSTRACT Controlled donation after circulatory death (cDCD) with thoracoabdominal normothermic regional perfusion (TA‐NRP) has emerged worldwide as a strategy to expand the heart donor pool. In Italy, however, its implementation is constrained by a particularly restrictive settin...

Phenotype-based appropriateness of IGM-enriched polyclonal immunoglobulin use in critical illness: report of an expert consensus

Sepsis and septic shock result from a dysregulated host response to infection, encompassing both hyperinflammatory and immunosuppressed phenotypes. Although immunomodulatory adjunctive therapies have been extensively investigated over the past decades, none have demonstrated cons...

CEUS for the diagnosis of acute graft pyelonephritis in renal transplant recipients

Abstract Purpose Acute graft pyelonephritis (AGPN) is a clinically relevant complication in renal transplant recipients, in whom diagnosis may be challenging because of nonspecific clinical and conventional ultrasound findings. Contrast-enhanced ultrasound (CEUS) enables real-tim...

Real-world Italian experience with asciminib in chronic myeloid leukaemia–chronic phase: case series and drug profile overview

Abstract Asciminib selectively targets the myristoyl pocket of ABL1, offering high specificity and a potentially improved safety profile. Its efficacy has been demonstrated in both clinical trials and real-world settings, including heavily pretreated patients and those with T315I...

What are the knowledge, use, and perceived benefits and limitations of artificial intelligence chatbots among Italian nursing students? A cross-sectional multicentre study

Exploring students’ knowledge, use, and perceptions of Artificial Intelligence (AI) chatbots may inform strategies in the educational context. However, limited evidence is available on Italian nursing students, leaving this field largely unexplored. A cross-sectional online surve...

Epidemiology, impact on oncologic treatments, and management of community-acquired respiratory virus (CARV) infections in pediatric onco-hematology patients: a survey among Italian pediatric oncology hematology centres (AIEOP)

Abstract A survey was conducted across Italian Pediatric Onco‑Hematology centres to assess epidemiology of community‑acquired respiratory virus (CARV) infections, chemotherapy management, Oseltamivir use and vaccination policies. Most reported infections were mild and managed out...

A survey on the institutional practices of the use of isavuconazole in onco-hematological children, on behalf of the Infectious Working Group of AIEOP

Isavuconazole is a broad-spectrum antifungal agent approved for the treatment of invasive fungal infections (IFIs) in adults and, recently, in pediatric patients aged 1 year and older. Use in the pediatric setting remains limited, but available data indicate generally favorable s...

Real-World Clinical Management of Keratoconus in Europe and the Middle East: A Multicountry Survey on Diagnostic and Surgical Practices (Keratoconus in Mind - KIM Project)

Purpose: This study aimed to describe the current management of patients with keratoconus in European and Middle Eastern countries through the collection of real-world data from clinicians actively managing keratoconus. Methods: Computer-assisted web interviewing survey targeting...

The Behavior of the External Limiting Membrane and Ellipsoid Zone in Diabetic Macular Edema: A Population AI-Assisted Optical Coherence Tomography Study

Purpose: To investigate the behavior of the external limiting membrane (ELM) and ellipsoid zone (EZ) in diabetic macular edema (DME) using artificial intelligence (AI)-based optical coherence tomography (OCT) quantification. Methods: This was a cross-sectional study. OCT scans of...

Total intravenous versus volatile anesthesia in living donor hepatectomy: A global prospective cohort study from the international LDLT registry

The choice between total intravenous anesthesia (TIVA) and volatile anesthesia for living donor hepatectomy remains controversial, with limited evidence comparing their impact on donor and recipient outcomes. This study evaluates the association between anesthetic technique and e...

Statistical quality in RCTs of technology-based rehabilitation after spinal cord injury: A CHAMP-Based Meta-Research Study

STUDY DESIGN: Cross-sectional meta-research study. OBJECTIVES: Technology-based rehabilitation (TBR) is increasingly used in spinal cord injury (SCI), with a growing number of randomised controlled trials (RCTs) evaluating its effectiveness. However, inadequate statistical report...

Long-term outcomes of iris-claw intraocular lens implantation in aphakic eyes: comparison of fixation techniques and incision types

Abstract Background Aphakia without adequate capsular support remains a challenging condition, and iris-claw intraocular lenses (IOLs) are a valuable option among secondary implantation techniques. This study aimed to evaluate the long-term outcomes of iris-claw IOL implantation...

Scalp Biopsies for Alopecia

Background: Hair loss is one of the most common reasons patients seek dermatologic evaluation. Although clinical examination and trichoscopy establish the diagnosis in most cases, scalp biopsy remains essential when findings are inconclusive, when cicatricial alopecia is suspecte...

Acute Limb Ischemia During Pregnancy: A Case Report and Narrative Review of the Literature

Background: Pregnancy is a well-recognized hypercoagulable state that increases the risk of thrombotic complications, most commonly venous thromboembolism. In contrast, arterial thrombosis, including acute limb ischemia (ALI), is exceedingly rare but potentially catastrophic, and...