Azienda Unità Sanitaria Locale Della Romagna

Travel distance to tertiary healthcare reflects disease severity and medication access in Italian systemic sclerosis patients: a geographical study on adult-onset rare diseases from SPRING-SIR registry

Systemic sclerosis (SSc) is a rare, multiorgan disease in adults that requires specialized care. Commuting to tertiary medical centers poses a considerable burden and incurs significant costs, potentially affecting management choices. This study aims to describe the healthcare co...

Ultrasound Assessment of Gallbladder Motility After Ingestion of a Bicarbonate-Rich Mineral Water (Aqua 3): A Randomized Crossover Study

Background: Bicarbonate mineral waters have been reported to modulate biliary dynamics. Prior symptom-based data with Aqua 3 suggested digestive benefits, but objective confirmation is still lacking. Aims: We sought to evaluate the effect of Aqua 3 on gallbladder motility in fast...

Off-label prescribing in pediatrics: between regulatory gaps and clinical evidence

Despite important regulatory progress, evidence supporting the use of medicines in children remains limited, and off-label prescribing continues to be common in pediatric practice. Regulatory initiatives such as the United States Pediatric Research Equity Act (PREA) and the Europ...

Antibody-Dependent Cellular Phagocytosis and Cytotoxicity in Patients With LGI1 and CASPR2 Encephalitis

This database includes the raw data linked with the paper “ Antibody-dependent cellular-phagocytosis and -cytotoxicity in patients with LGI1 and CASPR2 encephalitis”. Objective: Antibodies against LGI1 and CASPR2 (LGI1/CASPR2-IgG) associate with forms of autoimmune encephalitis (...

Integrating urgent care centers into primary care networks to reduce emergency department overcrowding: a real-world implementation and evaluation

Emergency Department (ED) overcrowding is a major challenge for health systems and is often driven by high volumes of low-acuity visits. In 2023, the Emilia-Romagna Region in Italy implemented a network of community-based Urgent Care Centers (UCCs) to provide timely care for low-...

Soil health assessment using buried cotton underpants with the help of 1000 citizen scientists

Societal Impact Statement Soil is a vital resource for life on Earth. Although many soils are degraded, societal awareness of soil‐related issues is limited. To highlight soil as a key resource and fascinating study system, we initiated a citizen science project together with 100...

Topical Ruxolitinib for Folliculitis Decalvans

The authors declare no conflicts of interest. The data that support the findings of this study are available from the corresponding author upon reasonable request.

A Novel α-Globin Gene Variant: Hb Romagna [α61(E10)Lys>Gln; HBA1:c.184A>C] Co-Inherited with Hb A2-Lampang [δ47(CD6)Asp>Asn; HBD:c.142G>A] in an Italian Diabetic Woman

Background: Screening for hemoglobinopathies, particularly in Mediterranean countries, is primarily aimed at preventing beta-thalassemia. However, during such screening, numerous other Hb defects can be diagnosed, each with different clinical significance, including qualitative a...

Real-world effectiveness of a multicomponent early intervention program for first episode psychosis in Emilia Romagna (Italy): Timeliness, specificity and fairness

Background This study provides a real-world evaluation of the multicomponent Emilia-Romagna First Episode Psychosis Program (RER-FEP) (2013–2019). It assesses how timeliness, treatment specificity, and socio-demographic factors related to fairness (including citizenship) are asso...