Athinoula A. Martinos Center for Biomedical Imaging

Improving neuropathological reconstruction fidelity via AI slice imputation

Neuropathological analyses benefit from spatially precise volumetric reconstructions that enhance anatomical delineation and improve morphometric accuracy. Prior work has shown the feasibility of reconstructing 3D brain volumes from 2D dissection photographs. However, these outpu...

Portable Low-Field MRI of the Brain in Clinic and Community Settings

This cohort study evaluates portable, low-field magnetic resonance imaging (MRI) against conventional MRI in memory clinic and community cohorts.

Design of a nonlinear double-breast single-axis gradient coil with controlled anterior–posterior gradient variation for diffusion-weighted imaging

Abstract Introduction High-performance whole-body gradient systems show promise for breast diffusion-weighted imaging, but their performance is constrained by physiological limits. Although local nonlinear gradient coils can provide stronger gradients while remaining within these...

Evaluation of clinical performance of artificial intelligence-assisted measurement of thoracic aortic diameter on non-contrast CT

This study aimed to evaluate the clinical performance of artificial intelligence (AI)-assisted measurement of thoracic aortic diameter on non-contrast computed tomography (NCCT). This single-center prospective study included 79 patients (mean age = 70 ± 13 standard deviation; 46...

Robust changes in brain function require high D2 receptor occupancy by prochlorperazine: an imaging correlate for the antipsychotic therapeutic window

Abstract The dopamine D 2 -receptor antagonist prochlorperazine is approved clinically as both an antipsychotic and an antiemetic. Classical antipsychotics like prochlorperazine have been shown to treat the positive symptoms of schizophrenia at occupancies higher than 60% with ex...

Elevated translocator protein in skull bone marrow is linked to human chronic pain

The skull bone marrow (SBM) is emerging as a critical hub for neuroimmune signaling, yet its role in chronic pain is unknown. Using integrated positron emission tomography/magnetic resonance imaging, here, we show that the levels of 18-kilodalton translocator protein (TSPO), a pu...

Functional fractionation of large-scale brain networks in the human subcortex

Brain network mapping plays a crucial role in advancing our understanding of human brain organization and the neuroanatomic foundations of cognition. Historically, the identification of large-scale brain networks has focused on the cerebral cortex. Some cortical networks have bee...

Localized brain delivery of drugs via focused ultrasound-responsive bi-layer nanobubbles

Focused ultrasound (FUS) in combination with micro- or nanobubbles is a promising strategy for transiently and non-invasively opening the blood-brain barrier (BBB) to enable targeted drug delivery to the brain. Here, we report a FUS-responsive delivery system using bi-layer nanob...

Hyperpolarized [2– 13 C]Pyruvate Identifies a Mitochondria‐Active Hepatocellular Carcinoma Phenotype With Vulnerability to Mitochondrial Inhibition

ABSTRACT Hepatocellular carcinoma (HCC) exhibits metabolic heterogeneity that is not fully characterized by glycolysis‐focused spectroscopic profiling. This study investigated whether in vitro hyperpolarized (HP) [2‐ 13 C]pyruvate NMR spectroscopy can identify a mitochondria‐acti...