Atatürk University

Real-world outcomes of children with first relapsed acute lymphoblastic leukemia treated according to the ALL-IC REL 2016 guideline in Türkiye

Relapsed acute lymphoblastic leukemia (ALL) remains a major challenge in pediatric oncology, particularly where access to modern immunotherapies is limited. This national multicenter study evaluated real-world outcomes of children with first relapsed ALL treated according to the...

Knowledge, Practice, and Socio‐Behavioral Determinants of Physical Activity Among Tunisian Medical Students: A Cross‐Sectional Study

ABSTRACT Background and Aims Physical inactivity has become a critical public health issue worldwide, contributing to numerous chronic diseases. As future healthcare providers, medical students' understanding and practice of physical activity are essential both for their personal...

Temperature‐Controlled Synthesis of Fe‐Based Graphite Nanocomposites for Sustainable Photocatalysis and Electrocatalysis Application

ABSTRACT This study reports the temperature‐controlled synthesis of iron‐based graphite nanocomposites prepared via a sol–gel route followed by electro‐spraying and evaluates their photocatalytic and electrocatalytic performance. At a calcination temperature of 750°C, the materia...

Use of Recycled Fine Aggregate in Wet-Mix Shotcrete Mortar Applications: The Role of Styrene–Butadiene Rubber Latex

Abstract This study investigates the feasibility of wet-mix shotcrete (WMS) mortars incorporating recycled fine aggregate (RFA), with a particular focus on the role of styrene–butadiene rubber (SBR) latex in mitigating the adverse effects of RFA on shootability and mechanical pro...

Coordinated upregulation of Hippo, NF-κB and interferon pathway genes in pancreatic ductal adenocarcinoma: a retrospective tissue qRT-PCR profiling study with external tumour-versus-non-tumour validation, molecular subtype and survival analyses

Pancreatic ductal adenocarcinoma (PDAC) is one of the most lethal solid tumours. Alterations in Hippo, NF-κB and interferon (IFN)-related signalling have each been implicated in its biology, but the extent to which these transcriptional programmes are coordinately dysregulated in...

Follicular Development in Cattle: Synchronization Protocols, Vasoactive Mechanisms, and Herd-Level Selection

Reproductive efficiency in high-producing dairy herds is strongly affected by disruptions in follicular dynamics, which become particularly evident during the postpartum period. Negative energy balance, increased steroid catabolism, and suppressed luteinizing hormone (LH) pulsati...

A medicolegal evaluation of attitudes toward euthanasia: psychometric validation of the ATE scale in Türkiye

Abstract Background Euthanasia remains a complex ethical, legal, and medical issue. Although euthanasia is not legally permitted in Türkiye, understanding medical students’ attitudes toward euthanasia is important for medical education, bioethical debate, and future policy discus...

Effects of Progressive Muscle Relaxation on Sleep Quality, Serotonin, and Melatonin in Hospitalized Cardiac Patients: A Randomized Controlled Trial

This study aimed to evaluate the effects of progressive muscle relaxation (PMR) on sleep quality and urinary 5-HIAA levels as an indicator of serotonin metabolism and urinary 6-HMS levels as an indicator of melatonin metabolism in hospitalized cardiac patients with sleep disturba...

Âsâr û Ahyâ’ya Göre İlhanlılar Döneminde Tarımsal Üretim ve Yetiştirme Teknikleri

Bu çalışmada İlhanlı dönemi tarihçisi ve devlet adamı Reşîdüddin Fazlullâh-ı Hemedânî’nin Âsâr û Ahyâ adlı eserinde yer alan tarımsal üretim ve yetiştirme teknikleri incelenmiştir. Çalışmanın amacı, farklı coğrafyalara ait tavsiye, gözlem ve rivayetleri bir araya getiren eserdeki...

Association of admission serum copeptin with hemorrhagic shock severity in adult trauma patients

Abstract Hemorrhagic shock remains a major cause of potentially preventable death after trauma, and early assessment of its severity is essential. This prospective observational biomarker study evaluated admission serum copeptin in 103 adult trauma patients. The primary analysis...

Reticulated Ferrocene−Polycarbazole Nanofibers Coupled with CuAl-LDH for Ultrasensitive Label-Free Electrochemical Detection of CA125

Abstract The development of highly sensitive and reliable sensing platforms for ovarian cancer biomarkers is of considerable importance for improving the early diagnostic performance and supporting clinical decision-making. Cancer antigen 125 (CA125) is among the most critical tu...

Resistance-interval training combined with Chlorella vulgaris supplementation modulates PCSK9, ghrelin, adropin, and MANF in obese men: a randomized controlled trial

Obesity disrupts lipid metabolism, appetite regulation, vascular function, and cellular homeostasis through interconnected pathophysiological mechanisms, increasing cardiometabolic disease risk. This randomized controlled trial examined whether 12 weeks of resistance-interval tra...

Enhancing critical thinking and social problem-solving through problem-based learning: a mixed-methods study among pharmacy students

Developing higher-order cognitive skills, particularly critical thinking and social problem-solving, is a central objective in pharmacy education and essential for patient-centered practice. Although problem-based learning (PBL) has been widely adopted to support such skills, mos...

Microbiological monitoring of scuba cylinders under routine filling and seasonal diving conditions

Introduction: The aim of this study was to monitor the microbiological status of the inner surfaces of scuba cylinders under routine air filling conditions and to assess whether microbiological contamination emerges or persists over time. Methods: A prospective longitudinal micro...

Bilateral sudden sensorineural hearing loss following indirect lightning exposure successfully treated with hyperbaric oxygen therapy: a case report

Introduction: Lightning injuries may result in a wide spectrum of neurological and otological complications. Sudden sensorineural hearing loss (SSNHL) following indirect lightning exposure is rare, and evidence regarding the role of hyperbaric oxygen therapy (HBOT) remains limite...

Effectiveness of concept map–based reflective learning for teaching peripheral intravenous catheterization to first-year nursing students: a cluster-randomized controlled trial

Traditional teaching methods in nursing education may not effectively integrate theory and practice. Concept map–based reflective learning may facilitate knowledge organization and support meaningful learning and critical thinking. This cluster-randomized controlled pretest–postt...

Microbiome-Derived Metabolic Signaling in the Gut–Skin Axis: Implications for Nutricosmetics and Healthy Skin Aging

The gut–skin axis represents a bidirectional communication network linking the gut microbiota, microbial metabolism, immune regulation, and skin physiology. Natural bioactives derived from dietary plants, mushrooms, fermented foods, marine resources, and functional ingredients ma...

Multilevel Analysis of Glutathione-Induced Responses in Pepper Seedlings Under Water-Deficit Conditions

Drought stress is a major abiotic factor that negatively affects plant growth, physiological processes, and yield in pepper cultivation. This study evaluated the ameliorative effects of exogenous glutathione (GSH) at 50 µM and 100 µM in pepper seedlings grown under water-restrict...

Chitosan–Orientin Nanoparticles Attenuate Hypoxia-Induced Pulmonary Inflammation in Rats

Background: Hypoxia triggers pulmonary inflammation and oxidative stress, leading to endothelial dysfunction, apoptosis and lung injury. Although the flavonoid orientin exhibits potent antioxidant and anti-inflammatory properties, its pharmacokinetic behavior remains incompletely...

Organizational ostracism and quiet quitting in healthcare a mediated moderated model of deviance and anxiety

Organizational ostracism experienced by healthcare workers in the workplace can reduce their motivation and productivity, potentially leading to undesirable behaviors such as quiet quitting. In this context, the roles of organizational deviance behaviors and anxiety levels among...