Astana Medical University

Population-Specific Genetic Markers of Prostate Cancer Risk in Kazakh Men: Association Analysis of 102 SNPs and Risk Prediction Modeling

Background/Objectives: GWASs have identified more than 250 prostate cancer (PCa) predisposition loci, predominantly in European and partly Asian cohorts. The Kazakh population is markedly under-represented in international genetic studies, limiting existing risk models. This stud...

MSC–Hydrogel Composite Systems for Knee Cartilage Repair and Osteoarthritis: A Systematic Review

Background: MSC–hydrogel composite systems were developed to overcome the poor cell retention and limited durability of conventional marrow stimulation and suspension-based MSC delivery. A rigorous synthesis of the clinical evidence is lacking. Objectives: To evaluate the safety...

Population Structure, Morphological Integration and Regional Differentiation of Dactylorhiza fuchsii (Druce) Soó in the Central Highlands of Kazakhstan

Dactylorhiza fuchsii (Druce) Soó is an ecologically sensitive terrestrial orchid and an important indicator of habitat condition, yet its population structure and morphological variability remain poorly studied in the Central Kazakh Uplands. This study evaluated the population si...

Multiplex RPA-CRISPR/Cas12a Assay for Rapid Detection of Class D OXA-Type Carbapenem-Resistant Acinetobacter baumannii

Acinetobacter baumannii is a critical WHO priority pathogen due to its multidrug resistance and high mortality in carbapenem-resistant infections. Resistance is predominantly mediated by class D carbapenemase genes blaOXA-23 and blaOXA-40, which spread rapidly via horizontal gene...

The impact of sustainability-driven and artificial intelligence-based personalisation on customer loyalty at South Asia-based airlines

The global aviation industry is rapidly switching to AI-based service systems, which leads to an important research question about the effectiveness of Western digital adoption frameworks in explaining the sustainable behaviour of distressed state-owned enterprises (SOEs) that op...

Exploratory SSR-Based Assessment of Genetic Diversity and Differentiation Among Four Wild Almond Populations in Kazakhstan

Wild almond relatives are valuable reservoirs of allelic variation for crop improvement and conservation, yet Kazakhstan’s wild-almond genetic resources remain poorly characterised. We conducted an exploratory SSR assessment of 80 putative individuals from four taxon-locality gro...