Assiut University

Decoding the causes of ischemic stroke despite ongoing oral anticoagulation and their clinical impact: the ASPERA-R study

BACKGROUND: Oral anticoagulants (OACs), including vitamin K antagonists and direct OACs, reduce stroke risk in atrial fibrillation (AF), yet breakthrough ischemic stroke still occurs in 1-2% of patients annually despite adequate therapy. The mechanisms underlying these events rem...

Angiographic and early in-hospital profile of primary percutaneous coronary intervention in patients with substance use disorder presenting with ST-segment elevation myocardial infarction

Abstract Acute myocardial infarction is increasingly recognized in younger adults, but the angiographic and early clinical profile of ST-segment elevation myocardial infarction among patients with substance use disorder remains incompletely defined. This single-center prospective...

Validation of the AO Spine Osteoporotic Fracture Classification—effect of geographical region on reliability and reproducibility

Regional differences affect the reliability of the AO Spine-DGOU Osteoporotic Fracture Classification. European participants showed the highest agreement. This study underscores the need for addressing regional factors to improve the system’s global clinical utility. To evaluate...

Sustainable Leadership, Workplace Integration, and Resilience Among Staff Nurses: A Cross-Sectional Correlational Study

Background: Sustainable leadership has emerged as a critical approach for promoting long-term organizational effectiveness and workforce well-being in healthcare settings. However, empirical evidence linking sustainable leadership to workplace integration and resilience among nur...

Evaluation of the new Egyptian undergraduate medical program from the perspectives of faculty and institutional leadership: a nationwide, mixed-method study

Abstract Background In response to global calls for medical education reform, Egypt restructured its national undergraduate medical education program from a 6 + 1 model to a competency-based “5 + 2” model. This reformed program emphasizes early clinical exposure, integration of b...

Efficacy and Safety of Baxdrostat for Patients With Uncontrolled or Resistant Hypertension: A Systematic Review and Meta-Analysis

We evaluated the efficacy and safety of baxdrostat in adults with uncontrolled or resistant hypertension. We searched PubMed, Scopus, Web of Science, and Cochrane CENTRAL from inception to January 2026. We included randomized controlled trials that involved hypertension patients...

Laparoscopic Burch Colposuspension Versus Transobturator Tape for the Treatment of Stress Urinary Incontinence in Egyptian Women: A 12‐Month Randomized Controlled Trial

AIMS: This study aimed to compare the efficacy, safety, and patient-reported outcomes of laparoscopic Burch colposuspension versus the transobturator tape (TOT) midurethral sling procedure for treating stress urinary incontinence (SUI) in Egyptian women. METHODS: This was a rando...

Spatial Heterogeneity of Global Organic Matter Accumulation During the PETM

Abstract The Paleocene–Eocene Thermal Maximum (PETM) was an abrupt global warming event triggered by a massive release of isotopically light carbon. Rapid recovery from the PETM has been attributed to enhanced burial of organic matter (OM). However, the mechanisms and spatial dis...

A 14-day repeated dose oral toxicity assessment of the aqueous-ethanolic extract of Schouwia purpurea in female Wistar albino mice

Schouwia purpurea (Family: Brassicaceae) S. purpurea is a wild medicinal plant traditionally used for treating gastrointestinal, inflammatory, and infectious disorders in arid regions of North Africa. Despite its ethnomedicinal importance, little is known about its systemic safet...

SETAS-VAD: Semantically Enriched Text-Aligned Scoring for Weakly Supervised Video Anomaly Detection

Weakly supervised video anomaly detection (WS-VAD) localizes anomalous events in untrimmed videos using only video-level annotations. While CLIP-based methods have advanced this task through vision–language alignment, widely adopted approaches construct text prototypes from short...

In vivo CRISPR screening identifies metastasis suppressors in triple-negative breast cancer

Metastatic cancer remains the leading cause of cancer-related mortality, yet tumor cell–intrinsic mechanisms restraining metastatic dissemination remain incompletely defined. Here, we perform an unbiased in vivo genome-wide CRISPR/Cas9 loss-of-function screen in a breast cancer x...

Sustainable Microcystin Removal from Water Using Low-Cost Agricultural Waste Materials

Cyanobacterial blooms are an increasing global concern due to the release of microcystins (MCs), potent hepatotoxins that threaten aquatic ecosystems, livestock, and human health. This study investigated the efficiency of low-cost natural adsorbents—rice straw (R), corn straw (C)...

Impact of MRI-to-surgery interval on pathological upstaging after robot-assisted radical prostatectomy: a real-world cohort study

Multiparametric MRI (mpMRI) is widely used for preoperative staging and surgical planning in prostate cancer. However, discrepancies between radiological and pathological staging are common. We evaluated staging concordance and investigated whether the interval between mpMRI and...

Monitoring pedestrian walking dynamics under environmental and policy influences in urban spaces

Abstract Understanding how environmental conditions and policy interventions jointly shape pedestrian mobility is essential for designing resilient, adaptive, and human-centered urban spaces. This study presents a computer-vision framework that extracts pedestrian trajectories fr...