Anhui University of Traditional Chinese Medicine

Rapidly deployable bio-based chitosan/phytate polyelectrolyte hydrogel coatings for flame retardancy and short-term thermal protection of cotton fabrics

Cotton fabrics are highly flammable cellulose-based textiles that are prone to rapid flame spread and smoldering, creating serious fire safety risks. Hydrogel coatings offer a promising route for textile fire protection because their water-rich networks can absorb heat through ev...

Homoisoflavanones, Alkaloid, and Norsesquiterpenoid from Polygonatum cyrtonema and Their Immunomodulatory Effects

Abstract Polygonatum cyrtonema (Huang jing) is widely used in both the food and traditional Chinese medicine industries. A chemical investigation of the rhizome of cultivated P. cyrtonema yielded six previously undescribed compounds─one norsesquiterpenoid (1), one pyridine alkalo...

An unintended consequence of sub-NOAEL triazole fungicides exposure: Bile acids disturbance mediated drug absorption perturbation

Triazole fungicides (TFs) are widely detected in food due to their extensive agricultural use. Current risk assessments of TFs, based on the no observed adverse effect level (NOAEL), mainly aim to prevent overt toxicities but overlook subtler physiological disruptions. TFs mainly...

Adrenalectomy versus conservative management in mild autonomous cortisol secretion: a systematic review and meta-analysis

Abstract Background Mild autonomous cortisol secretion (MACS) is common in adrenal incidentaloma care, but treatment evidence remains fragmented across modern MACS trials, older subclinical Cushing syndrome terminology, nonrandomized cohorts, and database studies. Methods We cond...

Myelin-Inspired 3D PEGylation of Framework Nucleic Acids Enables Simultaneous Long Circulation and Rapid Renal Clearance

The rational design of nanomedicines is fundamentally constrained by a physicochemical paradox at the bio-nano interface: strategies to prolong circulation inevitably suppress clearance, often resulting in long-term accumulation and systemic toxicity. To address this, we propose...

Metabolic reprogramming and polarization of microglia in cerebral ischemia: the roles of mitochondria and inflammasomes

Mitochondrial dysfunction, metabolic reprogramming, and NLRP3 inflammasome activation have been widely studied in post-ischemic microglia. However, a systems-level understanding of how these three processes interact as a spatiotemporal regulatory network is lacking. Furthermore,...

Global burden and inequalities of Hodgkin and non-Hodgkin lymphoma among children aged 0–14 years, 1990–2021: a GBD 2021 analysis with forecasts to 2035

OBJECTIVE: Childhood Hodgkin lymphoma (HL) and non-Hodgkin lymphoma (NHL) are potentially curable, but outcomes differ across development levels. The authors assessed global burden and inequalities among children aged 0-14 years from 1990 to 2021 and projected burden to 2035. MET...

Simultaneous Quantification of Eight Bioactive Markers Coupled With HPLC Fingerprint and Chemometric Analysis for Quality Discrimination of Saposhnikovia divaricata From Diverse Geographical Origins

Saposhnikovia divaricata (SD, Chinese name: Fangfeng) is a commonly used herbal medicine in traditional Chinese medicine (TCM), yet unclear chemical profiling and remarkable quality heterogeneity among commercial batches restrict its standardized quality supervision. This study e...

Regulatory roles of G-quadruplexes and G-quadruplex-binding proteins across the enhancer and promoter of the HBV genome

Hepatitis B virus (HBV) infection poses a global threat to human health due to the limited availability of effective treatment options. Recent studies have shown that the structures of G-quadruplex (G4) are related to the pathogenesis of the virus and potential targets for antivi...

NBS ‐Mediated Mitsunobu Glycosylation: Facile Assembly of N ‐Glycosides from Unprotected Sugars and Application to Polysaccharide Analysis

Comprehensive Summary Chemical N ‐glycosylation is a crucial step in the synthesis of complex N ‐glycosides, particularly nucleosides. However, traditional carbohydrate chemistry often relies heavily on protecting groups, which can lead to cumbersome, time‐consuming substrate pre...

Metabolic and vascular stress drive progression of erectile dysfunction in a rat model

Erectile dysfunction (ED) is a common male sexual disorder, with the vasculogenic subtype primarily driven by endothelial injury and metabolic dysfunction. Current research often lacks a systematic, time-course analysis of its progressive pathology. We performed a 16-week time-co...

CCR2-mediated chemotactic plant-derived extracellular vesicles for targeting and remodeling the immune microenvironment in cerebral ischemia-reperfusion injury treatment

The recruitment of peripheral immune cells into the brain and the subsequent formation of an inflammatory microenvironment are key drivers of cerebral ischemia-reperfusion injury (CIRI). Current nanosystem-based therapeutic strategies primarily target the brain parenchyma, yet of...

Routine clinical test markers with MRI anatomical anchoring for dysphagia risk identification in wilson disease: model development and external validation using a two-center database

Wilson disease (WD)-related dysphagia may lead to aspiration, pulmonary infection and malnutrition, but it is often recognized late in routine care. This study evaluated the value of routine clinical test markers, magnetic resonance imaging (MRI) topography and their integration...

Bioactive polysaccharides from the industrial crop Platycodon grandiflorus restore intestinal barrier integrity and suppress bEVs-mediated pyroptosis: A functional component for respiratory health management

Platycodon grandiflorus is widely recognized as an industrial crop due to the high value of its bioactive polysaccharides (PGP). Despite its traditional use for pulmonary and gastrointestinal health, the underlying mechanisms remain poorly defined. This study investigated whether...

High endophytic fungal diversity and the antagonistic Aspergillus niger Bzrh13 are associated with Atractylodes macrocephala root rot resistance

Root rot severely impairs the growth of Atractylodes macrocephala , a valuable medicinal plant. Despite the recognized importance of endophytic fungi in plant health, the endophytic fungal community associated with A. macrocephala root rot remains poorly characterized. Combining...

Adaptive Reinforced Gray Langur Optimization for Feature Selection and SVR Modeling of Polysaccharides in Dendrobium huoshanense via NIR Spectroscopy

Adaptive Reinforced Gray Langur Optimization (ARGLO), an enhanced variant of the Gray Langurs Optimizer, is developed for high-dimensional, multimodal, and nonlinear search landscapes susceptible to local trapping. Although the original GLO performs multi-population cooperative s...

Therapeutic Properties and Underlying Mechanisms of Traditional Chinese Medicine in Managing Rheumatoid Arthritis: An Integrative Review of Clinical and Molecular Findings

Traditional Chinese medicine (TCM) has a long-standing history in the treatment of rheumatoid arthritis (RA), known as "Bi Zheng," and offers a comprehensive therapeutic approach characterized by multi-target and multi-pathway mechanisms. Modern pharmacological research has demon...

Genome-wide characterization of the bZIP gene family in Rattus norvegicus and expression profiling analysis during brain development

The brown rat ( Rattus norvegicus ) serves as a cornerstone model organism in biomedical research, particularly for understanding physiological homeostasis and stress responses. The basic leucine zipper (bZIP) transcription factor family is a pivotal regulatory network involved i...

The effect of cochlear implantation in older adults: an umbrella review of systematic reviews and meta-analyses

INTRODUCTION: Age-related hearing loss is increasingly prevalent and impacts psychosocial wellbeing, cognitive health, and quality of life in older adults. While cochlear implants (CIs) are effective for severe-to-profound loss, their use in the elderly was historically cautious....

Interim Efficacy Analysis of Different Anticoagulation Regimens in Patients with Long-term Implantation of Inferior Vena Cava Filter

Abstract: To analyze the interim efficacy of different anticoagulation regimens for patients with long-term inferior vena cava filter (IVCF) implantation. From August 2021 to August 2024, a retrospective analysis of patients who underwent long-term IVCF implantation in multiple c...