Alfaisal University

Effectiveness of plasma atherogenic index as a predictor of cardiovascular risk in patients with metabolic syndrome and related cardiometabolic conditions: a systematic review.

Metabolic syndrome (MetS) and cardiovascular-kidney-metabolic syndrome represent escalating global health challenges characterized by complex lipid derangements. While traditional lipid panels are standard, the atherogenic index of plasma (AIP) has emerged as a potentially superi...

Baseline statin therapy and short-term mortality in acute pulmonary embolism: a multicenter cohort study

Abstract Background Statins exert anti-inflammatory and antithrombotic effects and have been associated with a reduced incidence of venous thromboembolism. Their impact on outcomes following acute pulmonary embolism (PE), however, remains uncertain. Objective To evaluate the asso...

Chemical characterization, antioxidant, anti-inflammatory, anti-parasite and cytotoxic activity of zingerone- and gingerol-rich extract of Zingiber officinale

The consumption of food item, delicacy, or herb such as Zingiber officinale (Roscoe) rhizome that are rich in antioxidant and anti-inflammatory properties improve the quality of life. Ginger rhizome has been utilized in traditional medicine for centuries for its therapeutic prope...

Candidate epistatic mutation clusters in occult hepatitis B virus genotype D: a critical narrative review of the evidence gap and a proposed testable framework

Hepatitis B virus (HBV) genotype D is the dominant genotype across the Middle East. It forms the background against which diagnostic assays, blood-screening algorithms, and vaccination programmes operate in the region. Occult hepatitis B infection (OBI), the presence of replicati...

Clinical characteristics and follow‑up of Saudi patients with adrenal incidentalomas: single‑center experience

Abstract Background Adrenal incidentalomas (AIs) are increasingly detected owing to the widespread use of cross-sectional imaging. However, real-world adherence to guideline-recommended evaluation remains variable. This study aimed to determine the prevalence, characteristics, an...

Decitabine Reprograms Temozolomide-Resistant Glioblastoma Through Epigenetic Reactivation and Mesenchymal Attenuation: A Multi-Omics Study

Background/Objectives: Glioblastoma (GBM) is the most lethal primary brain malignancy in adults, with a median overall survival of approximately 15 months. Temozolomide (TMZ) resistance develops in virtually all patients, and no second-line regimen has improved outcomes over the...

Temporal trends and demographic disparities in constipation-associated mortality in the United States, 1999–2024

Constipation is common and managed as benign; however, refractory disease can progress through fecal impaction to stercoral colitis, perforation, and sepsis. The national mortality trends are unmapped. Serial cross-sectional CDC WONDER multiple-cause analysis, US adults ≥ 25 year...

Public Knowledge, Practices, and Acceptance of Smart Health Technologies Addressing Antibiotic Use and Resistance in Saudi Arabia

Background: Antimicrobial resistance (AMR) remains a major global public health threat, largely driven by inappropriate antibiotic use. Smart health technologies (SHTs), including mobile health applications and digital stewardship tools, offer promising opportunities to improve a...

Nitrofurantoin Susceptibility and the Landscape of Multidrug-Resistant Gram-Negative Uropathogens in Kidney Transplant Recipients During the First Post-Transplant Year

Background: Multidrug-resistant (MDR) Gram-negative urinary tract infections (UTIs) frequently complicate the first post-transplant year in kidney transplant (KTX) recipients. This study characterized patterns of uropathogen susceptibility, MDR prevalence, and predictors of MDR U...

Digital epidemiology investments, Saudi Arabia.

Problem: Traditional epidemiological surveillance methods are often limited by delays in reporting and fragmented data systems. Saudi Arabia faces additional public health challenges from mass gatherings during Hajj and Umrah, an increasing burden of noncommunicable diseases and...