Al Azhar University

Superior Auricular Artery Fascial Flap for Second Stage Microtia Reconstruction

INTRODUCTION: The prevalence of microtia is high among the population, and 2-stage costochondral reconstruction using the Nagata technique is widely accepted. The second stage includes elevation of the previously carved framework to create the postauricular sulcus. Many technique...

A Pilot Head-to-Head Comparison of Two Bisulfite Conversion Kits for NGS-Based DNA Methylation Analysis of Liquid Biopsy Samples from Colorectal Cancer

Given the important role of early detection in improving cancer outcomes, epigenetic alterations, particularly DNA methylation, have emerged as powerful biomarkers for cancer screening and diagnosis. However, methylation profiling of cfDNA (circulating free DNA) presents particul...

Recent Horizons in Pyridine-Based Agrochemicals (2020-2026): From Molecular Design to Ecological Safety

Abstract Pyridine derivatives have emerged as indispensable pharmacophoric scaffolds in contemporary agrochemistry, driving breakthroughs across next-generation insecticides, plant growth regulators (PGRs), micronutrient chelators, and biostimulants. This review provides a compre...

Strengthening the Genetic Evidence for the FLNA c.5776C>T (p.Pro1926Ser) Variant: Comments on Segregation, X-inactivation, and Digenic Considerations

Background: We read with interest the reported mother–daughter case series describing the novel heterozygous FLNA c.5776C>T (p.Pro1926Ser) variant associated with epilepsy and variable multisystem manifestations. Discussion: We highlight several considerations that may further st...

Application of in vitro digestion and dialysability procedure for bioavailability evaluation of toxic elements in green leafy vegetables: a realistic health risk assessment by Monte Carlo simulation

Green leafy vegetables (GLVs), which are vital and widely consumed worldwide, require monitoring for contaminants, including toxic elements (TEs). This study measured total concentrations (TC) and bioavailable concentrations (BC) of arsenic (As), cadmium (Cd), lead (Pb), chromium...

A closer insight into the molecular effect of canagliflozin on gentamicin–induced nephrotoxicity in rats: Attention to SIRT1/Nrf2/HO-1, p38 MAPK/NF-κB signaling pathways, and expression of miR-21 and miR-155.

OBJECTIVE: Nephrotoxicity is considered the most detrimental effect of gentamicin (GM). In this study, we investigated the potential effects for canagliflozin (CANA) to protect against GM-induced nephrotoxicity, besides the multiple molecular pathways underlying these effects. ME...