Al-Azhar University

Unmasking the Hidden Cancer Risk in Chronic Rhinosinusitis: Systematic Review and Meta-Analysis

Chronic rhinosinusitis (CRS) has a complicated, multifaceted etiology. It is distinguished by inflammation of the nasal and sinus mucosa. We aim to investigate the association between CRS and various malignancies, as well as their underlying mechanisms. We included published stud...

Early Hemodynamic Prediction: A Critical Review and Clinical Insights

Blood flow abnormalities are central to cardiovascular and cerebrovascular diseases, yet early detection remains challenging due to invasive or resource‑intensive traditional methods. Deep neural networks (DNNs) offer a potential non‑invasive alternative by inferring hemodynamic...

Imaging findings of sacroiliac joint degeneration are prevalent in asymptomatic adults: a systemic review and meta-analysis

Abstract Objective The purpose of this study is to determine the prevalence of imaging findings of sacroiliac joint (SIJ) degeneration in asymptomatic adults. Materials and methods All studies reporting the prevalence of cross-sectional imaging findings of SIJ degeneration in asy...

Antimicrobial activity and ADMET analysis of novel coumarin-based pyridine and pyran hybrids

Abstract A series of novel pyridine and pyran incorporated chromene moiety have been synthesized using 6-(2-(4-nitrophenyl) diazenyl)-3-acetyl-2 H-chromen-2-one 1 as the starting material. The chemical structures of the newly synthesized derivatives were characterized using diffe...

Metabolite profiling and molecular docking insights into the wound healing efficacy of Pelargonium zonale in a rat burn model

Pelargonium zonale has a long history of use in traditional medicine for wound healing, supported by scientific evidence of its topical, hemostatic, and antibacterial properties. The current study aims to comprehensively investigate the wound healing potential and phytochemical p...

Patterns and drivers of beta diversity of Asteraceae across Africa: A taxonomic and phylogenetic approach

Unravelling the spatial and temporal dynamics of biodiversity is a central goal in ecology and evolutionary biology, requiring an integration of taxonomic and phylogenetic beta-diversity. However, a lack of comprehensive studies at continental scales for major ecologically divers...

Comparative phytochemical characterization and in vitro biological activities of coffee (Coffea arabica) and loquat (Eriobotrya japonica) seed extracts

The growing demand for natural bioactive compounds has intensified research into plant-derived extracts as plant-derived extracts as sources of bioactive compounds. Coffee ( Coffea arabica ) and loquat ( Eriobotrya japonica ) seeds represent underutilized sources of phytochemical...

Bioactive essential oils as sustainable postharvest technology: suppression of sprouting and preservation of physicochemical quality in cold-stored potato tubers

Sprouting during storage represents a principal postharvest constraint for potato ( Solanum tuberosum L.), driving physiological weight loss, quality deterioration, and severe loss of marketability. Furthermore, recent regulatory restrictions on synthetic suppressants, such as ch...

The silent pandemic: the overlooked toll of stroke compared to COVID-19

The COVID-19 pandemic will be remembered as one of the defining health crises of the modern era. The World Health Organization reported approximately 7 million deaths attributed to COVID-19 globall...

Intracanal cryotherapy and postoperative pain relief in symptomatic apical periodontitis: a systematic review and meta-analysis

Postoperative pain remains a frequent complication following nonsurgical root canal treatment and is particularly associated with inflammatory pulpal and periapical conditions. Intracanal cryotherapy has been proposed as a simple and biologically plausible adjunctive strategy aim...

Attenuation of cyclophosphamide toxicity by protective effects of curcumin in albino rats model

Abstract Background Chemotherapy primarily treats cancer by using drugs to kill cancer cells. Curcumin, a natural adjuvant, shows promise in preventing side effects. Purpose This study seeks to determine curcumin’s protective effect against cyclophosphamide toxicity. Materials an...

Efficient deep learning models for early Alzheimer’s disease diagnosis

Abstract Alzheimer’s Disease (AD) is a progressive neurological disorder that impairs cognitive functions, severely affecting patients’ quality of life. Thus, early and accurate diagnosis is essential to provide a chance for treatment. This paper proposes two deep learning (DL) m...

Prophylactic administration of probiotic strains Weizmannia coagulans and Saccharomyces boulardii attenuates early dysplastic changes in an AOM/DSS-induced mouse model

Abstract Background Colorectal dysplasia represents an early stage of colorectal carcinogenesis and is closely associated with chronic inflammation and altered microRNA (miRNA) expression. Probiotic strains such as Weizmannia coagulans (formerly Bacillus coagulans) and Saccharomy...

Surgeons and Experts’ Perspectives in Concomitant Bariatric Surgery with Cholecystectomy: Bari-Chole Egypt Survey

INTRODUCTION: The management of gallbladder disease during metabolic and bariatric surgery (MBS) remains controversial. Cholelithiasis is common in patients with obesity, yet the approach to concomitant or prophylactic cholecystectomy varies, with limited data from Egypt. This st...

Comparative efficacy and safety of antiemetics for pediatric gastroenteritis-related vomiting in emergency departments: a network meta-analysis

Background Vomiting is a leading cause of emergency department (ED) visits among children with acute gastroenteritis (AGE). Although antiemetics are commonly used, uncertainty persists regarding the comparative efficacy and safety of individual agents across clinically relevant t...

Green-synthesized nanoparticles for glass ionomer cement reinforcement: a systematic review of their antimicrobial, mechanical, and physicochemical properties

Abstract Aims This systematic review critically evaluates the antimicrobial performance, mechanical properties, and fluoride release of glass ionomer cements (GICs) modified exclusively with green-synthesized nanoparticles. The review highlights how eco-friendly nanoparticle prod...

Superior Auricular Artery Fascial Flap for Second Stage Microtia Reconstruction

INTRODUCTION: The prevalence of microtia is high among the population, and 2-stage costochondral reconstruction using the Nagata technique is widely accepted. The second stage includes elevation of the previously carved framework to create the postauricular sulcus. Many technique...

Percutaneous Endoscopic Interlaminar Lumbar Discectomy for Treating Acute Cauda Equina Syndrome: A Case Series of 25 Patients

Abstract Cauda equina syndrome (CES) is caused by compression of nerves in the lumbar spine below the conus medullaris. Symptoms include progressive weakness in the lower extremities, back pain with sciatica, saddle anesthesia, and urinary or bowel dysfunction. These symptoms var...

Frequency of pathological gambling among Egyptian patients with substance use disorders: a cross-sectional study

Abstract Background Pathological gambling and substance use disorders (SUDs) share overlapping neurobiological pathways and clinical features. However, the prevalence of pathological gambling among Egyptian patients receiving treatment for SUDs remains insufficiently explored. Ob...

BRCA1/2 variant profiling and HPV/HMTV DNA detection in a cohort of Egyptian women with breast cancer

Abstract Breast cancer (BC) is a multifactorial disease influenced by both genetic and environmental factors. Pathogenic variants in BRCA1 and BRCA2 significantly increase hereditary BC risk, while oncogenic viruses such as human Papillomavirus (HPV) and human mammary tumor virus...