Al-Azhar University

Comparative larvicidal efficacy and phytochemical profiling of selected Solanaceous hexane extracts against Culex pipiens and Aedes aegypti

Abstract Mosquito-borne diseases pose a major global health burden, and the effectiveness of conventional insecticides is increasingly limited by resistance and environmental concerns. This study provides a comparative assessment of the larvicidal activity and phytochemical compo...

Optimal design of hybrid renewable energy conversion systems using two configurations and four different algorithms for a rural village in Egypt

Abstract Decentralized energy systems can significantly enhance living circumstances in remote areas without a grid connection. This paper formulates a hybrid renewable energy model for a rural Egyptian village. The system includes PV, wind, biomass generator, battery storage, an...

Clinical consequences, treatment status, and parental awareness of traumatic dental injuries among high school students: a cross-sectional study in Cairo

Abstract Background This study assessed the current clinical consequences and treatment status of previous traumatic dental injuries (TDIs) affecting permanent anterior teeth among adolescents aged 15–17 years in Cairo, Egypt, and evaluated parental awareness and knowledge regard...

Detection of carbapenem resistance mechanisms in difficult-to-treat Pseudomonas aeruginosa clinical isolates from a tertiary care hospital in Egypt

Abstract Background The increasing incidence of carbapenem-resistant Pseudomonas aeruginosa (CRPA) poses a significant global health concern, particularly with the emergence of difficult-to-treat resistance (DTR), which seriously restricts therapeutic options. Therefore, we aimed...

Clinical performance of a giomer-based pit and fissure sealant with and without air-abrasion pretreatment: a 12-month randomized clinical trial

BACKGROUND: Pit and fissure sealants are widely used for caries prevention; however, their long-term success depends largely on retention. Giomer-based sealants containing surface pre-reacted glass ionomer fillers offer bioactive properties, yet concerns remain regarding their bo...

Integrating Azotobacter inoculation with nano-NPK foliar application: a sustainable strategy for enhancing growth, physiology, and sugar yield in sugar beet (Beta vulgaris L.)

Sugar beet is a key crop for the sugar industry, increasingly reliant on eco-friendly inputs to meet rising global demand. Plant growth-promoting rhizobacteria (PGPR) enhance plant growth via root associations, while nanotechnology offers solutions to limitations of traditional f...

Bioactive goldenseal (Hydrastis canadensis) fraction suppresses multidrug-resistant Pseudomonas aeruginosa in a rat burn wound model: oral and topical administration

Abstract Multidrug-resistant (MDR) Pseudomonas aeruginosa is a prominent pathogen implicated in burn wound infections, creating substantial therapeutic obstacles due to its antibiotic resistance and enhanced virulence mediated by quorum sensing (QS). This study explored the anti-...

Synergistic engineering of mixing A-site cations and oxygen vacancies to boost optical, electrochemical, and dielectric properties of Ag0.5Na0.5NbO3−δ

Ag 0.5 Na 0.5 NbO 3−δ lead-free perovskite was synthesized using a conventional solid-state method. X-ray diffraction (XRD) confirmed an orthorhombic (Pbcm) Ag 0.5 Na 0.5 NbO 3−δ perovskite phase with a small monoclinic (P2 1 /n) NaAgNb 4 O 11 phase. Transmission electron microsc...

Photocatalytic proximity labeling for the identification of G-quadruplex DNA-interacting proteins

Abstract DNA–protein interactions play an essential role in fundamental cellular biological processes. Herein, we report a photocatalytic proximity labeling approach for the broad screening of G-quadruplex (G4)-interacting proteins (G4IPs) using human telomere G4 DNA modified wit...

A Systematic Multi-Paradigm Evaluation Framework for Network Intrusion Detection in Fog-IoT Environments: Deep Learning, Transformer, and Ensemble Methods Across Deployment Tiers

This paper presents the Adaptive Confidence-Gated Ensemble (ACGE) framework for Network Intrusion Detection Systems (NIDSs) in resource-heterogeneous fog-IoT deployments. No single algorithmic paradigm simultaneously achieves high minority-class detection accuracy, sub-millisecon...

The filtration performance of fabrics against particles of viral size: a systematic review

Wearing a mask is part of the comprehensive strategy to suppress transmission of the SARS-CoV-2 virus and respiratory tract infections. Despite available COVID-19 vaccines, wearing a mask has remained one of the simplest and most effective ways. There was, however, little data av...

Molecular characterization and spoilage potential of yeasts isolated from traditional Egyptian Karish cheese

Traditional soft cheeses are susceptible to microbial contamination, particularly when unsterilized flavoring additives are used during production or retail handling. This study aimed to quantify and molecularly characterize the yeast flora associated with spiced Karish cheese, a...

Efficacy and Safety of Baxdrostat for Patients With Uncontrolled or Resistant Hypertension: A Systematic Review and Meta-Analysis

We evaluated the efficacy and safety of baxdrostat in adults with uncontrolled or resistant hypertension. We searched PubMed, Scopus, Web of Science, and Cochrane CENTRAL from inception to January 2026. We included randomized controlled trials that involved hypertension patients...

Evaluation of the new Egyptian undergraduate medical program from the perspectives of faculty and institutional leadership: a nationwide, mixed-method study

Abstract Background In response to global calls for medical education reform, Egypt restructured its national undergraduate medical education program from a 6 + 1 model to a competency-based “5 + 2” model. This reformed program emphasizes early clinical exposure, integration of b...

Oral Co-supplementation with Pediococcus pentosaceus Probiotic and Enteric Polymeric Phycocyanin Nanoparticles Mitigates Aging-Related Biomarkers in Male Wistar Rats: A Preclinical Investigation

Abstract C-phycocyanin (C-PC) is a promising anti-aging nutraceutical due to its antioxidant and anti-inflammatory properties; however, its instability under acidic conditions limits its efficacy, necessitating advanced formulation strategies. This study evaluated the anti-aging...

Sustainable synthesis of Ag/UiO-66 composites using recycled silver for efficient adsorption of methylene blue and crystal violet

Abstract Synthetic dyes are persistent and toxic water pollutants that require efficient removal technologies, and metal–organic frameworks (MOFs) have emerged as promising adsorbents for this purpose. In this work, a defect-engineered zirconium-based UiO-66 framework was synthes...

Phytochemical profile and in vitro antimicrobial, antiviral, and anticancer activities of Echium angustifolium ethanolic extract

Echium angustifolium is traditionally valued for its therapeutic properties; yet comprehensive studies on its biological activities are limited. Aerial flowering parts were sequentially extracted with solvents of varying polarity. Extracts were analyzed for yield, phytochemical c...

Effect of diode laser on micro-tensile bond strength of hybrid ceramic restorations to dentin using one-step and two-step self-etch adhesives: in vitro study

Abstract Background This study aimed to evaluate the effect of diode laser irradiation on the micro-tensile bond strength (µTBS) of hybrid ceramic restorations bonded to dentin using one-step and two-step self-etch adhesives. Methods An in vitro study was conducted using 20 fresh...

A sensitive and green spectrofluorimetric method for determination of guanfacine hydrochloride based on NBD-Cl derivatization

A sensitive and environmentally friendly spectrofluorimetric method was developed for the determination of guanfacine in pharmaceutical formulations. The method is based on derivatization of guanfacine with 4-chloro-7-nitrobenzofurazan in alkaline medium to yield a highly fluores...

Evaluation of Moringa oleifera extract and metal-organic frameworks (MOFs) as therapeutic agents against chronic Toxoplasma gondii infection in mice

Abstract Toxoplasmosis, a zoonotic infection caused by the protozoan Toxoplasma gondii , remains a significant global health concern, with seroprevalence exceeding 60% in specific regions. Given the limitations of current therapies for chronic stages, this study investigated the...