Akershus University Hospital

Nicotinamide Riboside for Patients With Early-Stage Parkinson Disease

Importance Nicotinamide riboside, a nicotinamide adenine dinucleotide precursor, has been proposed as a potential disease-modifying therapy for Parkinson disease based on preclinical and early studies. Whether prolonged oral nicotinamide riboside improves clinical outcomes in Par...

Analysis of circulatory extracellular vesicle–associated cytokines as candidate disease-associated markers in ER-positive breast cancer

Abstract Introduction Cytokines are signaling molecules produced by various cell types, including immune cells, and play important roles in tumor development and progression. Extracellular vesicles (EVs) are small membrane-bound particles secreted by all cell types, including can...

AI-assisted discovery of an ABCA1/ABCG1 activator for restoring mitophagy and mitigating Alzheimer’s pathology

Abstract Defective mitophagy is a key pathological risk of Alzheimer’s disease (AD), yet available pharmacological agents capable of restoring mitophagy remain clinically limited, largely due to the lack of tools for drug screening and target identification. To address this, we i...

Major adverse cardiac events and mortality associated with ADHD and its treatment in adults with type 2 diabetes: a multi-national cohort study

Abstract Background Attention-deficit/hyperactivity disorder (ADHD) has been linked to elevated risk of type 2 diabetes (T2D). However, the impact of ADHD and ADHD medication use on prognosis and health outcomes in T2D remains unclear. This study investigates the associations of...

From Fear to Function: How Physiotherapists Navigate Psychological Challenges in Patients Undergoing Rehabilitation After ACL Reconstruction

Background: Psychological readiness plays a critical role in return to sport (RTS) outcomes after anterior cruciate ligament reconstruction (ACLR), yet physiotherapists (PTs) often feel unprepared to support this aspect of recovery. Although clinical guidelines advocate for psych...

Does active surveillance prior to radical prostatectomy increase the risk of adverse pathological findings or postoperative prostate cancer treatment?

Active surveillance (AS) is an established management strategy for men with low- and favorable intermediate-risk prostate cancer (PCa). Nevertheless, a substantial proportion of patients ultimately undergo radical prostatectomy (RP), and the impact of prior AS on subsequent outco...

Gut microbiome signatures of colorectal cancer development are more pronounced in women compared to men in a population-based screening cohort

Abstract Background The gut microbiome has emerged as a promising source of biomarkers to enhance early detection of colorectal cancer (CRC). However, sex-specific differences in gut microbial profiles and their relationship to CRC risk remain underexplored. Our objective was to...

Atrial cardiomyopathy and MRI-detected covert brain infarction in an elderly population-based cohort: the Akershus Cardiac Examination 1950 study

Abstract Introduction Atrial fibrillation is associated with both clinical stroke and covert brain infarction (CBI). Atrial cardiomyopathy has been proposed in absence of atrial fibrillation as an independent stroke risk factor, but supporting evidence is limited. This study aime...

Castration‐resistant prostate cancer cells are addicted to the high activity of cyclin‐dependent kinase 2

Abstract Background Cyclin-dependent kinases drive the progression through the cell cycle and thereby form classical targets for cancer therapy. In prostate cancer (PC), the first line of therapy typically targets androgen receptor (AR), but it frequently leads to development of...

Sex differences in dementia with Lewy bodies: a systematic review

Abstract Sex differences are increasingly recognized across neurodegenerative disorders, including Dementia with Lewy Bodies (DLB). Despite ongoing refinement of diagnostic criteria, DLB remains frequently misdiagnosed—particularly among females—reflecting gaps in our understandi...

Extended D3 Mesenterectomy in Small Bowel Cancer Treatment: Feasibility and Importance for Staging. First Results of a Prospective Clinical Trial

ABSTRACT Background There is no consensus on surgical techniques in small bowel cancer, particularly regarding the extent of lymph node dissection and strategic choices according to tumor localization and histological type. Clearance of central lymph node metastases can be challe...

Patients’ Mental Barriers in Rehabilitation after ACL Reconstruction: A Qualitative Interview Study

Background Recovery after anterior cruciate ligament reconstruction (ACLR) involves both physical and psychological challenges. Although psychological readiness for return to sport (RTS) is increasingly recognized as important, less is known about how patients experience psycholo...

Familial Co‐Aggregation of Neurodevelopmental Conditions and Childhood‐Onset Type 1 Diabetes

ABSTRACT Aim Childhood‐onset Type 1 diabetes (T1D) is associated with neurodevelopmental conditions (NDCs). We examined whether this association extends to relatives and assessed phenotypic, genetic, and environmental correlations between T1D and NDCs. Methods Using Swedish regis...

Adolescents at the crossroads: genetic associations between psychotic symptoms and antisocial traits

<title>Abstract</title> Antisocial behaviour in youth has serious consequences at individual and societal level. Adolescence is also a critical period for the emergence of prodromal psychosis symptoms. Their co-occurrence may aggravate aggression and lead to severe adverse outcom...

Voice metrics and workload in helicopter rescue: insights from ninety-six cockpit recordings

The relationship between subjective workload and task performance is multifaceted. In aviation research, task performance is typically evaluated using multiple variables. Voice metrics can provide valuable insights regarding operational improvements and offer objective assessment...

Cardiovascular and cognitive consequences of steep head-down tilt in awake older men

This study investigated cerebral hemodynamics, intracranial pressure, and cognitive function in eighteen older men (median 72 years, IQR 68-75, 94% with ≥1 comorbidity) during a 15-minute 30-degree head-down tilt (HDT). Participants were monitored with continuous non-invasive hem...