Air Force Medical University

Clinical Outcome Differences in Asia Versus Non-Asia Intracerebral Hemorrhage: IPD Analysis From BP-Lowering Clinical Trials

BACKGROUND: Evidence of regional differences in clinical outcomes after intracerebral hemorrhage (ICH) is still scarce. We quantified differential outcomes and response to early intensive blood pressure lowering treatment by region in the Blood pressure in Acute Stroke Collaborat...

The Toxic Effects and Mechanism of Acetamiprid Exposure on Testicular Tissue: ALKBH5 Regulates m6A Modification to Affect PI3K-AKT-Mediated Apoptosis

(1) Background: Acetamiprid, a widely used neonicotinoid insecticide, has increasingly drawn people’s attention to its potential reproductive toxicity risks. Although existing studies have shown that exposure to acetamiprid can cause testicular damage, its underlying molecular me...

Treg‐stromal cell axis in tissue repair and autoimmune diseases: Mechanisms and clinical translation

Abstract Tissue repair and regeneration constitute a complex biological process, meticulously orchestrated by the immune system and stromal microenvironment. In this context, the dynamic crosstalk between regulatory T cells (Tregs) and stromal cells acts as the central regulatory...

CRISPR screening identifies TWIST1 as a ferroptosis driver in CKD progression

Chronic kidney disease (CKD) lacks effective therapeutic interventions targeting its fundamental pathological mechanisms. TWIST1 is a basic helix-loop-helix transcription factor that is a critical regulator in kidney fibrosis pathogenesis. We used genome-wide CRISPR-Cas9 screenin...

Association of dexmedetomidine use with stroke-heart syndrome in critically ill patients with ischemic stroke: a MIMIC-IV study

Background Stroke-heart syndrome (SHS) is associated with poor outcomes after ischemic stroke (IS), but the relationship between dexmedetomidine (DEX) use and SHS remains unclear.Objective To evaluate the association between DEX use and SHS in critically ill patients with IS.Meth...

Mapping the global research landscape and emerging trends in tumor treating fields for cancer therapy

This study aims to map the structural landscape, collaborative networks, and thematic evolution of Tumor Treating Fields (TTFields) research via quantitative bibliometric analysis. By interpreting dataset structures rather than providing a traditional narrative review, it seeks t...

Advantage of cerebellar intermittent theta-burst stimulation in Alzheimer's disease (ACT-AD): study protocol for a multicenter, randomized, double-blind, sham-controlled trial

Abstract Introduction The cerebellum plays a crucial role in cognitive processing and thus presents a promising therapeutic target for Alzheimer’s disease (AD). This trial aims to evaluate the efficacy and safety of long-term, neuronavigated cerebellar intermittent theta burst st...

Acute Whole-Body Heat Exposure Modulates EEG Microstate Dynamics, Phase-Lagged Connectivity, and Cortical Source Activity

Abstract Acute exposure to elevated ambient temperature affects physiological regulation, thermal perception, and cognitive functioning, yet its influence on the spatiotemporal organization of human brain activity remains insufficiently understood. This study investigated tempera...

ZC3H13-Mediated m 6 A Modification of TRIM16 Suppresses EndMT and Atherosclerosis by Destabilizing Ang2 and Inhibiting the TLR4/NLRP3 Pathway

The RNA methyltransferase zinc finger CCCH-type containing protein 13 (ZC3H13) is downregulated in atherosclerosis (AS), but its functional mechanism remains unclear. Endothelial-mesenchymal transition (EndMT) is a core pathological driver of endothelial dysfunction in AS. This s...

Drp1 in M1 layer V GABAergic neurons orchestrates rTMS-mediated motor restoration and analgesia after spinal cord injury

Abstract Spinal cord injury (SCI) leads to chronic motor and sensory deficits, with progressive secondary neurodegeneration posing a major therapeutic challenge. Although high-frequency repetitive transcranial magnetic stimulation (HF-rTMS) over the primary motor cortex (M1) show...

Moldavoside ameliorates hypertension and autoantibodies targeting the angiotensin II type 1 receptor-induced endothelial damage via regulation of RhoE/CAV-1/eNOS axis

Globally, more than 100 million patients with resistant hypertension experience severe endothelial damage. Therefore, exploring the mechanisms underlying endothelial damage and developing effective interventions is urgently required. The clinical data and biochemical indicators o...

Fumarate Hydratase Lactylation Exacerbates Traumatic Brain Injury Pathology via Mitochondrial Dysfunction and Neuroinflammation

ABSTRACT Traumatic brain injury (TBI) induces brain tissue ischemia, hypoxia, and heightened glycolysis, leading to lactate accumulation. Lactate exerts multiple pathophysiological effects in the aftermath of TBI. This study aimed to elucidate the role of lactate‐mediated lactyla...

Leveraging the Iron-Probe-MurB Interaction: An Enhanced Platform for PET Imaging of Bacterial Infections

Abstract The accurate discrimination of bacterial infections from sterile inflammation is a critical yet unresolved challenge in clinical diagnostics. To address this, we designed and synthesized a series of 68Ga-labeled PET tracers derived from the FDA-approved iron chelator, de...

Salidroside ameliorates glucocorticoid-induced osteoporosis by regulating the PI3K/Akt/mTOR pathway: a network pharmacology and in vivo

Osteoporosis (OP) is a bone disorder, common cause of bone fracture and disability. Management of it needs development of an alternative medicine and present report evaluates the protective effect of salidroside against glucocorticoid induced osteoporosis in rat model. Network ph...

Self-regulated immune-neurovascular bone repair scaffold via functional surface features

Given specific microenvironment of bone repair, the novel implant endowed with self-regulated bone healing procedure was the representative trend of bio-functional decoration. Inspired by the microstructure and chemical composition of natural bone, bioactive calcium titanate coat...

Association of atherogenic index of plasma with gestational diabetes mellitus and birth weight outcomes, and the mediating role of blood glucose

AIMS: This study aimed to examine the associations of maternal first-trimester atherogenic index of plasma (AIP) with gestational diabetes mellitus (GDM) and birth weight outcomes, and the mediating role of second-trimester blood glucose. METHODS: [TG (mg/dL)/HDL-C (mg/dL)] from...

Decoding patients’ voices: how social media reviews reveal the true impact of medical service

An increasing number of patients share their medical experience on social media, which are valuable resources for improving medical services and patient experience. This study focused on several top-tier large general Grade-A tertiary hospitals in China. It collected and organize...

Transcutaneous Auricular Vagus Nerve Stimulation Selectively Improves Executive Control and Cognitive Flexibility Following Sustained High Cognitive Load: A Randomized, Single-Blind, Sham-Controlled Study

Objectives: Acute exposure to sustained high cognitive load rapidly depletes executive functions, yet rapid, field-compatible countermeasures remain scarce. This study examined whether transcutaneous auricular vagus nerve stimulation (taVNS) improves cognitive functions across mu...

MATR3 is essential for oocyte growth and maturation quality through a dual molecular mechanism

The molecular mechanisms governing mRNA accumulation during oocyte growth, essential for developmental competence, remain poorly understood. This study investigates the role of Matrin-3 (MATR3), a highly expressed RNA-binding protein in growing oocytes (GOs), using oocyte-specifi...

Genome-scale insights into the genetic diversity and pan-genome architecture of Orientia tsutsugamushi

Scrub typhus is a neglected vector-borne zoonosis caused by Orientia tsutsugamushi (OT), an obligate intracellular bacterium with a heterogeneous, repeat-rich genome. Molecular epidemiology of OT has long relied on single marker loci, but whether marker-based classifications refl...