Ahvaz Jundishapur University of Medical Sciences

Association of TNFAIP3 Polymorphisms With Bleeding Phenotypes and FVIII Inhibitor Development in Patients With Hemophilia A: A Case‐Control Study

ABSTRACT Background Hemophilia A is an X‐linked bleeding disorder caused by factor VIII (FVIII) deficiency. While F8 gene mutations are the primary cause, immune and inflammatory pathways contribute to variability in clinical phenotype and FVIII inhibitor development. TNFAIP3, en...

The Relationship Between Kinesiophobia, Anxiety and Depression in Patients With Heart Failure: The Role of Patients' Perception of Nursing Care

ABSTRACT Background Heart failure is associated with psychological and behavioural challenges. Kinesiophobia and perceived nursing care may influence psychological outcomes, but their relationships remain unclear. This study examined the links between kinesiophobia, perceived nur...

Using multi-trait polygenic scores to predict lithium responsiveness in patients with bipolar disorder

Background The predictive power of polygenic scores (PGSs) for lithium treatment response in bipolar disorder remains limited. Aims To enhance the prediction of lithium responsiveness by developing a multi-trait PGS (mt-PGS) combining genetic information from multiple phenotypes...

Extracellular Vesicles, Exosomes, and Cancer: Detection and Therapeutic Monitoring

Abstract Extracellular vesicles (EVs) are membrane-bound vesicles released by cells into the extracellular space. Exosomes are a nanoscale subtype of extracellular vesicles (typically 30–200 nm) secreted by almost all types of cells. They carry a diverse molecular cargo, includin...

Circadian Clock Crosswalk Between Chronic Disease and Antitumor Response

Circadian disruption is increasingly recognized as a contributing factor in both chronic disease and impaired antitumor immunity; however, these two fields have largely evolved independently. We conducted a Scale for the Assessment of Narrative Review Articles-guided narrative re...

Interventions to promote sustainable and healthy food choices in universities: a scoping review

Abstract Background University settings play a crucial role in shaping the dietary habits of young adults. In response to growing concerns about public health and environmental sustainability, increasing attention has been directed toward interventions that promote healthy and su...

Association between dietary fatty acids and all‐cause mortality in patients with cirrhosis: A cohort study

Abstract Liver cirrhosis imposes a substantial global burden, with complications driving high mortality. Diet is pivotal in managing liver disease progression and cirrhosis‐related death. This study investigated associations between total fat intake, specific dietary fatty acid s...

Association between anemia and cardiovascular disease among adults aged 35-70-years: a population- based cross- sectional study

The importance of anemia in relation to cardiovascular disease (CVD) has received considerable attention in epidemiological and clinical research. Therefore, this study aimed to investigate the association between anemia and cardiovascular disease. The present population-based cr...

Bifidobacterium longum prevent the progression of colon cancer via inhibiting metastasis and angiogenesis

Colorectal cancer (CRC) is one of the most common reasons for cancer-related death, and both angiogenesis and metastasis have established roles in CRC progression. Recent findings suggest that probiotics, like Bifidobacterium longum, are capable of suppressing anti-cancer activit...

Protodioscin mitigates cyclophosphamide-induced renal toxicity in HEK-293 cells by regulating endoplasmic reticulum stress, antioxidant defense, and apoptotic pathways

Cyclophosphamide (CTX) is a widely used chemotherapeutic agent with well-established efficacy; however, its clinical use is limited by dose-dependent adverse effects, particularly nephrotoxicity. Protodioscin (Prot), a bioactive saponin derived from plants of the Dioscoreaceae fa...

α-Santonin from a marine sponge exhibits anticancer activity and mechanistic effects in colorectal cancer

Colorectal cancer (CRC) requires new therapeutic agents with minimal systemic toxicity. Marine-derived natural products represent a promising source of drug candidates because of their unique bioactivity. This study evaluated the anti-tumor potential and possible molecular mechan...

Neuroprotective potential of linagliptin against mancozeb induced neurotoxicity

Abstract Background The research investigates the neuroprotective effects of Linagliptin (Lina), a dipeptidyl peptidase-4, against the neurotoxic impacts of Mancozeb (MNZ), which is known to cause cognitive deficits and oxidative stress. Methods: The study involved six groups of...

Investigating the occurrence of different antibiotic resistance genes in Enterococcus faecalis and Enterococcus faecium isolates from burn patients in Ahvaz, southwest Iran

The aim of this study was to determine the prevalence of some antibiotic resistance genes in enterococci isolates collected from burn patients in Ahvaz, southwestern Iran. In this cross-sectional study, a total of 129 Enterococcus isolates were identified by biochemical and molec...

Effect of a multilevel blended intervention based on social cognitive theory on fruit and vegetable consumption in students

Inadequate fruit and vegetable (F&V) consumption among adolescents remains a critical global public health challenge. This cluster-randomized controlled trial evaluated the effectiveness of a SCT-based multilevel blended intervention in increasing F&V consumption-frequency scores...

Ethical dimensions of suicide prevention education in health professions: A narrative review

Suicide prevention education is essential for healthcare providers, yet significant ethical gaps exist in how this sensitive topic is taught. Medical educators face complex challenges balancing clinical rigor with ethical responsibilities toward patients and students. This narrat...

Exosomes improved oxidative stress and apoptosis in BPA-induced nephrotoxicity in kidney cells through modulation of Nrf2/Keap1 signaling pathway

Bisphenol A (BPA) is an environmental toxicant known to induce nephrotoxicity primarily through oxidative stress–mediated inflammation and apoptosis. Mesenchymal stem cell-derived exosomes have recently emerged as promising cell-free therapeutic agents with antioxidant and anti-a...

The association between stress hyperglycemia ratio and adverse outcomes in patients with chronic kidney disease: a systematic review and meta-analysis

Chronic kidney disease (CKD) increases risks of cardiovascular events and mortality, so reliable biomarkers are needed to improve risk stratification. Stress hyperglycemia ratio (SHR), which adjusts acute glucose levels for chronic glycemia using glycated hemoglobin, has shown pr...

The effectiveness of clinical guideline on the caregiving performance of mothers with children with cystic fibrosis: A clinical trial study

Cystic fibrosis is an inherited disorder that causes severe damage to the lungs, digestive system, and other organs of the body. The aim of this study was to determine the effectiveness of clinical guidelines on the caregiving performance of mothers with children with cystic fibr...

The effect of the delivery mode on the total antioxidant activity, oxidative stress, and serum bilirubin level in G6PD-deficient male newborn infants

Glucose-6-phosphate dehydrogenase (G6PD) deficiency is a common condition worldwide that significantly increases the risk of neonatal hyperbilirubinemia and bilirubin encephalopathy. While some G6PD-deficient neonates exhibit hemolysis triggered by known oxidative exposures, such...

Acellular lung matrix scaffold coated by fibronectin enhances hepatic differentiation of adipose-derived mesenchymal stem cells

End-stage liver disease is a multifactorial disorder and leading cause of death.The development of effective tissue models has been a focus of research for treating liver disease.This study investigated the use of acellular lung matrix (ALM) and fibronectin (FN) to culture adipos...