Agostino Gemelli University Polyclinic

Safety and Efficacy of Acute Normovolemic Hemodilution in Female Patients

Importance Female patients undergoing cardiac surgery have a higher transfusion burden, yet they remain underrepresented in randomized clinical trials. Although the ANH trial showed no significant reduction in the proportion of patients receiving allogeneic blood transfusions wit...

Recurrent Primary Angiosarcoma of the Breast: Challenges and Pitfalls in a Case Report

AIM: Primary breast angiosarcoma (PBA) is an exceptionally rare and highly aggressive vascular malignancy with poor prognosis, high recurrence rates, and limited evidence guiding management. We report a case of low- to intermediate-grade PBA characterized by multiple local recurr...

Successful Nonsurgical Management of Norovirus-Associated Necrotizing Enterocolitis in a Preterm Infant: A Case Report

Norovirus infection has been increasingly reported in association with necrotizing enterocolitis (NEC) in preterm neonates, although the clinical spectrum remains poorly defined. We report the case of a 29-week preterm male infant who developed abdominal distension on day 35 of l...

Implementation of IRRAflow active irrigation in neurosurgical patients: A case series and literature overview

Background Active fluid management systems such as IRRAflow aim to overcome the limitations of passive external drains by enabling simultaneous automated irrigation and aspiration in a closed circuit. In acute and chronic subdural hematoma (a/cSDH), it enables active subdural irr...

Sustainable iodine contrast media for a healthy future (SUSTAINED): a global survey of practice

Abstract Objectives To investigate healthcare professionals’ knowledge, attitudes, and practices (KAPs) of the environmental impact and sustainability of iodinated contrast media (ICM). Materials and methods A cross-sectional web-based survey was distributed to members of profess...

Managing growth and puberty concerns in individuals with Duchenne muscular dystrophy: Updated guidance and future directions

Long-term glucocorticoid therapy is standard of care for individuals with Duchenne muscular dystrophy (DMD) but often results in impaired growth and delayed or incomplete puberty, impacting their physical and psychosocial health. Although DMD endocrine care has evolved, leading t...

Assisted Reproductive Technology and Risk of Congenital Heart Defects in the Offspring: A Systematic Review and Meta‐Analysis

Background To date, >10 million children have been conceived via assisted reproductive technology (ART) globally. However, there are some concerns about potential adverse outcomes associated with ART‐conceived pregnancies, including the risk of congenital heart defects (CHDs). Th...

Travel distance to tertiary healthcare reflects disease severity and medication access in Italian systemic sclerosis patients: a geographical study on adult-onset rare diseases from SPRING-SIR registry

Systemic sclerosis (SSc) is a rare, multiorgan disease in adults that requires specialized care. Commuting to tertiary medical centers poses a considerable burden and incurs significant costs, potentially affecting management choices. This study aims to describe the healthcare co...

Disproportionate systolic blood pressure response relative to oxygen consumption identifies a high-risk haemodynamic phenotype in arterial hypertension

OBJECTIVES: Conventional definitions of hypertensive response to exercise (HRE) rely on absolute systolic blood pressure (SBP) thresholds, which do not account for the metabolic demand driving the pressor response and show inconsistent association with pathophysiology and prognos...

Preliminary evidence of long‐term safety and effectiveness of anti‐ CGRP drugs for migraine prevention in people with comorbid epilepsy: A 52‐week follow‐up retrospective study

Abstract Migraine and epilepsy frequently coexist, but evidence on the safety of calcitonin gene‐related peptide (CGRP)‐targeting therapies in people with epilepsy is lacking. We evaluated long‐term migraine and epilepsy outcomes in a real‐world multicenter retrospective cohort o...

Everything you always wanted to know about sleep, but you were afraid to ask: expert concise guide and recommendations on assessing sleep-wake disturbances within a psychiatric context in contemporary times

OBJECTIVE: While disrupted sleep has long been linked to mental disorders there has been a notable decrease in interest and sleep-wake disorders have received low priority in psychiatric care. The aim of the paper was to present a concise guide for evaluating common sleep-wake di...

Lung disease in crisponi/cold-induced sweating syndrome type 1: expanding the clinical phenotype spectrum

Crisponi/Cold-Induced Sweating Syndrome Type 1 (CS/CISS1) is an ultra-rare genetic disorder caused by biallelic variants in the cytokine receptor-like factor-1 (CRLF1) gene and is associated with several comorbidities. Comprehensive data on the respiratory phenotype of this condi...

Patient Satisfaction and Perceived Stress in Digestive Endoscopy

OBJECTIVE: To evaluate patient satisfaction and perceived stress among adults undergoing diagnostic digestive endoscopy in Italy and to examine their associations with sociodemographic, clinical, and procedural factors. BACKGROUND: Patient satisfaction is a key indicator of endos...

Diagnosing Lennox–Gastaut syndrome in adulthood: A scoping review of diagnostic challenges and age‐related electroclinical evolution

OBJECTIVE: Lennox-Gastaut syndrome (LGS) is a developmental and epileptic encephalopathy typically diagnosed in childhood. The 2022 International League Against Epilepsy (ILAE) criteria provide a diagnostic framework built on pediatric data, but their applicability in adulthood i...

Mitochondrial Remodeling and Impaired Bioenergetics Define Neuronal Vulnerability in Fragile X-Related Disorders

Fragile X syndrome (FXS) and related conditions associated with FMR1 gene alterations have increasingly been linked to mitochondrial dysfunction, although most available evidence derives from peripheral cell models. Whether these abnormalities also occur in disease-relevant neuro...

Tibial Component Malalignment in Total Ankle Arthroplasty

Background: Total ankle replacement (TAR) has emerged as a valuable alternative to ankle arthrodesis for the treatment of end-stage ankle osteoarthritis, offering pain relief while preserving joint motion and improving quality of life. Despite advances in implant design and surgi...

Mixed Epithelial Stromal Tumour of the Seminal Vesicle Presenting with Recurrent Acute Urinary Retention: A Case Report

Background: Mixed epithelial stromal tumour (MEST) is a rare biphasic neoplasm, most commonly arising in the kidney. Seminal vesicle involvement is exceedingly uncommon, and its clinical and imaging characteristics remain poorly defined. We present a rare case with detailed clini...

Focused Ultrasound-Mediated Blood–Brain Barrier Opening for Enhanced Drug Delivery in Diffuse Gliomas: A Systematic Review

Background/Objectives: The blood–brain barrier (BBB) severely limits the intratumoral delivery of systemically administered therapeutics in diffuse gliomas, including glioblastoma (GBM), contributing to the persistently poor prognosis of these tumors. Focused ultrasound (FUS) com...

Scaling of an evidence-based intervention program in older people with diabetes and frailty in Latin America. Diabfrail-Latam clinical trial protocol

Objectives Diabfrail-Latam is a project funded by the Horizon 2020 program of the European Commission (EC) and the Global Alliance for Chronic Diseases (GACD). The main objective of this protocol is to describe the clinical validation of a multimodal intervention aimed at older p...

Biological aging for the advancement of biogerontology: Between hopes and hypes

Population aging has intensified the search for biological measures that can explain why individuals of the same chronological age differ so markedly in health, function, resilience, and disease burden. Geroscience has provided a powerful framework by linking shared mechanisms of...