Agency for Science, Technology and Research

Magneto-mechano-electrochemical fiber for deformation-resilient and smart electronic textiles

Electronic textiles represent a transformative platform for integrating technology into daily wear, yet their development has been undermined by a fundamental challenge: the conflicting requirements between mechanical deformation for functionality and structural stability for per...

Targeting MDA5 induces immunogenic cell death and promotes anti-tumor immunity

Identifying targets to enhance tumor immunity is an urgent need. Although nucleic acid sensors play critical roles in promoting tumor immune clearance, their exceptionally low mutation rate in cancers suggests potential unexplored roles in tumor progression. Here, we demonstrate...

Antibacterial and Biocompatible Iodine-Releasing Polycationic Coatings Synthesized by Solvent-Free Initiated Chemical Vapor Deposition

Abstract Bacterial adhesion to surfaces of medical devices may cause medical device-associated infections. This challenge can be addressed by surface modification utilizing antibacterial coatings. Polycationic coatings possess excellent antibacterial activity, but their biocompat...

Trajectory-Constrained Feature Transformation Optimization Framework for Stable Tabular Data Reprogramming

Tabular data reprogramming is a cornerstone of Data-Centric AI, which seeks to mathematically reconfigure raw features into more expressive and model-efficient representations. This process has traditionally relied on extensive manual engineering. Further, recent automated featur...

Implementing reproductive carrier screening to include diverse Asian populations: insights from Singapore

Abstract Background As part of Singapore’s effort towards precision medicine tailored to Asian diversity, we describe the implementation of a nationwide reproductive carrier screening program. Using a customised 112-gene panel, targeting population-specific recessive genetic dise...

Mask‐Free Electro‐Addressable Localization of GOx@ZIF‐8 on Prussian Blue Microelectrodes for Glucose Biosensing

Precisely integrating MOF powders into patterned electrochemical devices remains a processing challenge, as conventional methods often require masks, manual alignment, or poorly scalable steps and can lead to non-selective deposition and inefficient material use. While electropho...

Mechanisms and clinical characteristics of organ injury in severe fever with thrombocytopenia syndrome: a comprehensive review

Severe fever with thrombocytopenia syndrome (SFTS) is an emerging tick-borne zoonotic disease caused by Bandavirus dabieense (commonly referred to as SFTS virus, SFTSV), with a case-fatality rate as high as 30%. Although SFTSV is mainly found in East Asia (China, Japan, and South...

Implementation of Hencky’s elasticity model in Abaqus UELs for robust modelling of finite deformation

Hencky’s elasticity model extends Hooke’s law from infinitesimal to large deformation and has been shown to accurately describe the mechanical behavior of materials at moderately large deformation. However, the native implementation of Hencky's model in Abaqus yields poor converg...

Atomic Scale Origin of the OER Activity–Stability Trade-Off in NiFe Layered Double Hydroxides: Lattice-Site Oxygen Triggers Fe Leaching

Abstract NiFe layered double hydroxide (NiFe-LDH) is a representative non-precious-metal catalyst for the alkaline oxygen evolution reaction (OER), yet its long-term stability is compromised by Fe leaching under OER conditions. Herein, using density functional theory calculations...

Emulation of Synaptic Functions with Poly(Ionic Liquid) Heterojunction for Visual Pattern Recognition

Abstract The progress in artificial intelligence has driven the development of bioinspired iontronics for neuromorphic computing, offering scalability and energy efficiency. Ionic-liquid-based iontronic devices have emerged as capable of emulating the complex functions of neurons...

Targeting chondroitin synthase 1 attenuates hyperplastic arterial remodeling via gene therapy

Chondroitin sulfate glycosaminoglycans accumulate excessively in the extracellular matrix during pathological remodeling and exacerbate cardiovascular deterioration. Here we show that chondroitin synthase 1 (CHSY1) is the primary enzyme responsible for chondroitin sulfate synthes...

Distinct inflammatory marker profiles of adolescents and young adults among the HIV risk, infection, and treatment spectrum

Abstract Youth living with or at HIV-risk exhibit distinct immune perturbations during HIV exposure, infection, and antiretroviral therapy (ART). Understanding immune perturbations is critical for development of tailored prevention and enhanced therapeutic strategies. We performe...

Complementary Hydrogel-Based Ionic Thermoelectric Systems for Photovoltaic Waste Heat Harvesting and Energy Storage

Photovoltaic (PV) operation generates substantial low-grade waste heat, motivating energy-recovery strategies that can accommodate dynamically varying thermal conditions. Here, thermogalvanic and thermodiffusive hydrogel-based ionic thermoelectric (iTE) devices were separately in...

Cutaneous IgG4 ‐Related Disease Accompanied by Granulomatous Vasculitis: A Case Report

ABSTRACT IgG4‐related disease (IgG4‐RD) is a systemic fibroinflammatory disorder characterized by dense infiltration of IgG4‐positive plasma cells, fibrosis, and elevated serum IgG4 levels. Although various cutaneous manifestations of IgG4‐RD have been described, and vasculitic c...

Extreme‐Fast‐Charging Li‐Ion Batteries via Activation‐Energy Regulation With a Li 3 PO 4 ‐Li 2 SO 4 ‐Rich Solid Electrolyte Interphase

ABSTRACT Extreme‐fast‐charging (XFC) batteries are essential for widespread electric vehicle adoption. Although heating‐assisted charging enables ultrafast charging at elevated temperatures (e.g., 65°C), it increases the risk of thermal runaway. Lowering the activation energy of...

Genome-wide analysis of social behaviour across social domains, reporters and developmental stages: a meta-regression approach

Abstract Social behaviour is a heritable trait linked to well-being and mental health, yet it varies across social context, including social domains, informants and development, which may shape its underlying genomic architecture. Here, we conducted a genome-wide meta-regression...

Genomic and transcriptomic landscape of spread through air spaces in stage 1 lung adenocarcinoma

INTRODUCTION: Spread through air spaces (STAS) is an adverse histologic feature in early-stage lung adenocarcinoma (LUAD) incorporated into the ninth edition TNM staging. Despite its clinical significance, the molecular features underlying STAS in stage 1 LUAD remain incompletely...

Ultrahigh flow strength in shocked nanopolycrystalline diamond

Extreme pressures and temperatures create conditions that allow even hard and brittle materials to flow plastically. Despite extensive research, the limits of flow strength under such conditions remain uncertain, and the mechanisms driving deformation at the relevant stresses are...

Omnidirectional bending sensor with three-fold structural symmetry enables decoupling of bending angle and direction

Accurate shape sensing requires simultaneous quantification of bending angle (φ) and bending direction (θ). Yet existing bending sensors remain confined to uniaxial or discretized modes, relying on tedious, non-generalizable calibration procedures. Here, we present a snowflake-sh...

Distinct migratory dendritic cell subsets cooperate to prime tissue-resident memory-like CD8⁺ T cells in mouse tumors

Tumor-infiltrating tissue-resident memory (TRM)-like CD8+ T cells correlate with positive prognosis and better responses to cancer immunotherapy, yet the mechanisms underlying their specification remain ill-understood. Here, we use the KP (KrasG12D, p53-/-) mouse model of lung ad...