Agency for Science, Technology and Research

Synthetic data to explore transcriptional regulation of differentially expressed genes in ovarian cancer

In major diseases like cancer, many genes are dysregulated. While differential expression (DE) analyses help identify these genes, they do not reveal the transcriptional regulatory landscape between control and disease states. Here, we developed a process-driven model based on ge...

Inferring tumor dependency maps from histopathology through imputed transcriptomics

Gene dependency maps from cancer cell lines define context-specific essential genes, but comparable dependencies in tumors remain largely inaccessible. This gap limits the identification of actionable therapeutic vulnerabilities. Here we present a two-stage deep learning framewor...

Atomically thin amorphous carbon with an ultralow dielectric constant

Two-dimensional (2D) materials could replace conventional electronic components. Key advances have already been made in applying 2D materials to integrated circuits, but a robust, atomically thin ultralow-k dielectric remains crucial for further circuit scaling. Minimizing parasi...

Proteomic Profiling of Human Sweat Reveals Molecular Adaptations to Heat Acclimatization Induced by Isothermic Conditioning

Introduction: Prolonged physical exertion in hot and/or humid environments can induce physiological strain and increase the risk of heat exhaustion or exertional heat stroke (EHS). Heat acclimatization (HA) optimizes an individual’s ability to tolerate heat and is therefore widel...

DUSP4 promotes anti-tumor CD8+ T cell function and boosts CAR-T cell efficacy in mouse colorectal cancer

The activation and function of CD8+ T cells, which are central for anti-tumor immunity, are tightly regulated by extracellular and intracellular signaling pathways. Dual-specificity phosphatases (DUSP), including DUSP4, dephosphorylate serine/threonine and tyrosine residues of pr...

Gemfibrozil promotes longevity and health by restricting amino acid uptake through the Dipeptide transporter, PEPT1

The FDA-approved fibrate, gemfibrozil, has been used clinically to treat hyperlipidaemia, showing efficacy both in lowering triglycerides and increasing high-density lipoproteins. However, in recent years, the drug has been increasingly investigated for potential clinical use in...

Symmetry-DependentUltrafast Spin Currents and THzEmissions in Noncollinear Antiferromagnetic Mn3Pt/Pt Heterostructures

Abstract Noncollinear antiferromagnets (NCAFs) provide a symmetry-rich platform for ultrafast spintronics, where light-driven spin currents are governed by both crystallographic orientation and magnetic symmetry. Here, we investigate femtosecond-laser-induced terahertz (THz) emis...

Cannabinoids suppress chemotherapy- and ionizing radiation-induced apoptosis of glioblastoma cells

Abstract Cancer patients are increasingly exposed to cannabinoids, the bioactive molecules produced by the Cannabis sativa La. plant. This trend is being driven by several factors: expanding cannabis legalization, FDA approval of select cannabinoids for the treatment of seizures...

High‐Performance Self‐Assembled Amphiphilic Block Copolymer Thermoelectric Ionogel for Low‐Humidity Heat Harvesting

ABSTRACT Ionic thermoelectric (i‐TE) materials have attracted considerable interest due to their abilities to generate high thermovoltage for low‐grade waste heat harvesting. However, challenge still remains to develop high‐performance i‐TE materials, especially at relative low h...

Risk of new‐incident mental health diagnoses following SARS ‐ CoV ‐2 infection amongst children and young adults in Singapore: a retrospective cohort study

Background Mental‐health‐disorders in children/young adults increased post‐pandemic; however, the absence of linkage to COVID‐19 registries made direct attribution of psychological sequelae to acute infection challenging. Methods Healthcare‐claims databases in Singapore were util...