Affiliated Hospital of Southwest Medical University

Molecular Features of Heatstroke Revealed by Integrated Proteomics and Metabolomics

Abstract Heatstroke is a critical medical condition marked by hyperthermia-induced immune dysregulation, endothelial damage, and organ dysfunction, yet its molecular mechanisms are not fully elucidated. In this study, serum samples from heatstroke (HS) patients and normal control...

Association between timely and standardized nursing pain management and outcomes in terminal cancer patients

Effective pain management is essential for terminal cancer patients in emergency settings, yet nursing protocol adherence remains suboptimal. This study aimed to evaluate the association between key nursing process indicators and pain relief outcomes in terminal cancer patients p...

Modified cardiopulmonary bypass in low-weight adults: a randomized controlled trial of inflammatory factor changes and the potential for transfusion savings

Cardiopulmonary bypass (CPB) is an essential technique in cardiac surgery; however, conventional CPB systems may induce hemodilution and inflammatory responses, particularly in patients with low body weight. This study aimed to evaluate the effects of a modified CPB system on per...

Synthesis and Preliminary Biological Evaluation of a Structurally Modified Niraparib-Based PARP-Targeted PET Tracer for Tumor Imaging

Abstract Poly(ADP-ribose) polymerase (PARP) is highly expressed in various malignancies and represents an important therapeutic target. Noninvasive evaluation of PARP expression is therefore of potential clinical significance for patient stratification. In this study, we develope...

Association of uric acid-to-albumin ratio with diabetic kidney disease

This study investigates the association between a novel inflammatory marker, the uric acid-to-albumin ratio (UAR), and diabetic kidney disease (DKD). We used multivariable logistic regression models to evaluate the independent associations of UAR with DKD, albuminuria, and reduce...

A retrospective cohort study of the association between triglyceride-glucose index and its derived indicators and all-cause mortality among community-dwelling adults with a history of stroke

Abstract Objective As a novel marker of insulin resistance, the triglyceride-glucose (TyG) index has been documented to correlate with mortality in coronary artery disease and heart failure. In recent years, growing attention has been paid to the relationship between the TyG inde...

Preparation of Uniform Nonspherical PLGA Particles in the Nanosize Range by Using a Two-Step Premix Membrane Emulsification Technique

Abstract The shape of polymeric particulate systems is a critical determinant of their in vivo fate, and nonspherical nanoparticles are promising candidates for advanced drug delivery. However, spherical-shaped particles are usually produced by conventional emulsion-based methods...

CTCF-FXN regulatory axis plays critical roles in clinical assessments and disease progression of primary open-angle glaucoma

Primary open-angle glaucoma (POAG) is an irreversible ophthalmic disease that is the leading cause of blindness. Oxidative stress (OS) is considered an important contributor to POAG pathogenesis. However, its mechanism of action in POAG remains vague. FXN was identified as a cand...

Dihydroartemisinin overcomes cisplatin resistance in bladder cancer via suppression of the PI3K/AKT/ABCB1 signaling Axis

Abstract Cisplatin resistance substantially limits the efficacy of bladder cancer chemotherapy, and effective strategies to overcome resistance remain insufficient. In this study, we demonstrate that dihydroartemisinin (DHA) restores cisplatin sensitivity in resistant bladder can...

Preoperative ECG-based machine learning model for early prediction and risk stratification of postoperative delirium

Postoperative delirium (POD) is a serious neuropsychiatric complication that commonly occurs within days after surgery. Early identification of high-risk individuals is crucial for implementing effective preventive and management strategies. This paper developed a machine learnin...

Circulating and intraplaque interleukin-40 is associated with CTA-defined high-risk carotid plaques: an integrated imaging, serological, and histopathological study

Risk assessment of carotid atherosclerosis is moving beyond stenosis-based evaluation toward the identification of biologically active plaque phenotypes. Although CTA can characterize high-risk plaque morphology, biomarkers that reflect the inflammatory processes underlying these...

Antineoplastic agent-induced palmar-plantar erythrodysaesthesia syndrome: insights from the FDA adverse event reporting system

Palmar-plantar erythrodysaesthesia syndrome (PPE), also called hand-foot syndrome (HFS), is a common cutaneous adverse reaction to anticancer drugs that impairs patients’ quality of life. This study analyzed PPE reports from the U.S. FDA Adverse Event Reporting System (FAERS) to...

Association of sarcopenia with bone metabolism markers and development of an internally validated screening model for sarcopenia in maintenance hemodialysis patients

Sarcopenia is a prevalent complication in maintenance hemodialysis (MHD) patients and is associated with adverse outcomes. This study aimed to investigate the relationship between sarcopenia and bone metabolism markers and to develop a clinical screening model for sarcopenia in M...

Topologically distinct intratumoral heterogeneity scores for predicting high-risk pathological grades in invasive lung adenocarcinoma: A multicenter study across four institutions

High-risk subtypes of invasive lung adenocarcinoma (IAC), particularly micropapillary- or solid-predominant patterns, are closely associated with poor prognosis. This multicenter retrospective study developed and validated a predictive model for the preoperative identification of...

Discordant ¹⁸F-FDG and ⁶⁸Ga-DOTATATE PET/CT Findings Before Radionuclide Therapy in Small Cell Lung Cancer

A 54-year-old man with progressive small cell lung cancer underwent ¹⁸F-FDG and ⁶⁸Ga-DOTATATE PET/CT before radionuclide therapy. ¹⁸F-FDG PET/CT evaluated disease extent and identified metabolically active lesions. ⁶⁸Ga-DOTATATE PET/CT showed high SSTR expression in bone lesions...

68Ga-FAPI-04 PET/CT has high diagnostic efficacy in Tg-positive and Tg-negative differentiated thyroid cancer

Background Thyroglobulin (Tg) is a standard biomarker for monitoring differentiated thyroid carcinoma (DTC) after radioiodine therapy, yet its reliability is compromised by false-positive and false-negative results. This study aimed to evaluate the diagnostic performance of 68 Ga...

Sodium-glucose cotransporter-2 inhibitors and gastrointestinal neoplasm risk in type 2 diabetes: a systematic review and meta-analysis of randomized controlled trials

Abstract Background The potential carcinogenic effects of sodium-glucose cotransporter 2 (SGLT2) inhibitors in patients with type 2 diabetes mellitus (T2DM) remain controversial, particularly regarding site-specific gastrointestinal (GI) neoplasms. This systematic review and meta...

SNAI2/SLUG: a key regulator of endothelial-to-mesenchymal transition and vascular remodeling in cardiovascular diseases

Snail family transcriptional repressor 2 (SNAI2), also known as SLUG, is a canonical driver of epithelial-mesenchymal transition (EMT). While its oncogenic roles are well-established, emerging evidence underscores its pivotal involvement in cardiovascular diseases (CVDs). This re...

Motivation, engagement, and perceived competence gains in competition-based medical education: a theory-informed structural equation modeling study

Competition-based learning is increasingly used in medical education to promote active participation, innovation, and collaborative problem solving. However, less is known about how students’ participation motivation, engagement, perceived competence gains, and satisfaction are r...

Janibacter melonis bone marrow infection in an immunocompetent child with prolonged fever of unknown origin: a case report

Abstract Introduction Janibacter melonis ( J. melonis ) is a rare environmental actinomycete with only three previously reported human infections, all presenting as bacteraemia — all in adults, two of whom were immunocompetent and one of whom had refractory diffuse large B-cell l...