Affiliated Hospital of Shandong University of Traditional Chinese Medicine

Single-cell transcriptomics and machine learning characterize LTA4H-linked lipid metabolism and inflammatory signatures in the knee osteoarthritis IPFP/synovium compartment

Knee osteoarthritis (KOA) is a whole-joint disease characterized by inflammation, immune dysregulation, and metabolic imbalance. To define lipid metabolism-related transcriptional heterogeneity within the infrapatellar fat pad (IPFP)/synovium compartment, we integrated publicly a...

Direct oral anticoagulants versus vitamin K antagonists in cirrhotic portal vein thrombosis: a systematic review and meta-analysis of clinical, radiological, and safety outcomes

The optimal anticoagulant strategy for portal vein thrombosis (PVT) in patients with cirrhosis remains uncertain. This systematic review and meta-analysis compared the clinical, radiological, and safety outcomes associated with direct oral anticoagulants (DOACs) versus vitamin K...

Gastric cancer burden from 1990 to 2021, Joinpoint analysis, projections to 2036, and health inequality assessment

Gastric cancer (GC) remains a major global health issue with high incidence and mortality. This study evaluates the global burden and health disparities of GC from 1990 to 2021 and projects trends through 2036, providing evidence for targeted control measures. The data were sourc...

From baseline levels to cumulative exposure and longitudinal trajectories: estimated glucose disposal rate and incident cardiometabolic multimorbidity among middle-aged and older adults in the English Longitudinal Study of Ageing (ELSA) and the Health and Retirement Study (HRS)

Abstract Background Insulin resistance is implicated in the development of cardiometabolic multimorbidity (CMM), but evidence regarding the associations of baseline, cumulative, and longitudinal patterns of estimated glucose disposal rate (eGDR) with incident CMM remains limited....

Predictors of clinical pregnancy after IVF in women with ovarian endometriomas: a propensity score-matched retrospective cohort study

Abstract Background Ovarian endometrioma (OMA) is associated with reduced in vitro fertilization (IVF) success rates. Therefore, the purpose of the study is to investigate risk factors associated with pregnancy outcomes following IVF in women with OMA and assess the predictive ut...

A Collective CRISPR-Cas12a Biosensing Platform for Effect-Based Screening of Pesticide Residues

The simultaneous screening of multicomponent pesticide residues, rather than a single specific compound, remains a critical yet challenging frontier in safety surveillance, largely due to the inherent one-to-one recognition bottleneck in conventional aptamer- or antibody-based bi...

Exploring causal relationships between circulating inflammatory proteins and superficial thrombophlebitis

This study explores the potential causal relationship between circulating inflammatory proteins and superficial thrombophlebitis (STP) using Mendelian randomization (MR). We utilized data on 91 circulating inflammatory proteins from publicly available genome-wide association stud...

Acupuncture Alleviates Allergic Rhinitis by Activating the AMPK / PGC ‐1α Pathway to Attenuate Mitochondrial Oxidative Stress and Restore Epithelial Barrier Function

ABSTRACT This study aims to elucidate the molecular mechanisms underlying the therapeutic effects of acupuncture in allergic rhinitis (AR), with a focus on its mechanistic pathways. Experimentally, an ovalbumin (OVA)‐induced AR mouse model was established to evaluate the frequenc...

Prediction of low oocyte retrieval in young women undergoing IVF/ICSI: a multicenter external validation study

Abstract Objective To externally validate a previously developed pretreatment prediction nomogram for identifying young women at risk of low oocyte retrieval (LOR). Methods This multicenter retrospective study included 14,702 women aged ≤ 35 years undergoing their first in vitro...

Association between triglyceride-glucose-related indices and reproductive lifespan: a cross-sectional study from the NHANES (2007–2020)

Objective The female reproductive lifespan, characterized by the period spanning from menarche to menopause, may be modulated by metabolic health factors. This cross-sectional analysis utilized nationally representative survey data from the National Health and Nutrition Examinati...

Adjuvant lenvatinib plus transarterial chemoembolization is associated with better outcomes than gemcitabine plus cisplatin in combined hepatocellular cholangiocarcinoma

To evaluate and compare the efficacy and safety of lenvatinib combined with transarterial chemoembolization (TACE) and gemcitabine plus cisplatin (GP) as adjuvant treatments for combined hepatocellular-cholangiocarcinoma (cHCC-CCA), and to explore the differential therapeutic ben...

Multilevel Mechanisms and Clinical Efficacy of Psilocybin in Depression Treatment: A Systematic Review

Depression, characterized by persistent low mood and anhedonia, represents a prevalent affective disorder imposing substantial medical and economic burdens. Current first-line antidepressants are limited by delayed onset and treatment resistance. Psilocybin (PSI) has re-emerged a...

Comparative effects of core decompression combined with autologous cell-based strategies on structural outcomes in early-stage osteonecrosis of the femoral head: a systematic review and Bayesian network meta-analysis of randomized and quasi-randomized controlled trials

Core decompression (CD) creates a reparative environment for revascularization and bone repair in early- to mid-stage osteonecrosis of the femoral head (ONFH), but structural outcomes remain heterogeneous and autologous cell-based augmentation strategies are biologically distinct...

Ferro-aging: a potential driver of degenerative bone and joint diseases

Degenerative bone and joint diseases (DBJDs), including osteoporosis (OP), osteoarthritis (OA), and intervertebral disc degeneration (IVDD), are chronic age-related disorders characterized by progressive destruction of bone and joint tissues and loss of function, posing a heavy g...

Analysis of the awareness of core knowledge on lung cancer prevention and treatment among relatives of medical students

Abstract Background Medical students are well-positioned to share scientifically valid and precise information about lung cancer prevention with their families. This practice plays a crucial role in enhancing awareness of core knowledge on lung cancer prevention and treatment (CK...

Simultaneous Determination of Total and Unbound Amphotericin B by LC–MS/MS: Application to Protein Binding Analysis

ABSTRACT Amphotericin B (AmB), a first‐line antifungal agent, is highly protein‐bound, and its efficacy and toxicity are primarily determined by the unbound fraction. However, current therapeutic drug monitoring mainly relies on total plasma concentrations, and clinical data on u...

Latent profile analysis of postpartum depression symptoms and its associations with weight stigma and eating behaviors among postpartum women in China

Abstract Background Postpartum depression (PPD) represents a significant maternal health challenge with diverse symptom manifestations. Traditional analytical approaches that treat postpartum women as a homogeneous group may obscure distinct symptom patterns, limiting the develop...

Effects of vegetarian or vegan diets on cardiovascular metabolic health in patients with cardiovascular disease: a systematic review and meta-analysis

Vegetarian or vegan diets have been associated with favorable cardiovascular outcomes in the general population; however, their effects on cardiometabolic risk factors in patients with established cardiovascular disease (CVD) remain unclear. This systematic review and meta-analys...

Biomarker implications of gene editing in hematologic diseases: latest updates from ASH 2025

The 2025 American Society of Hematology (ASH) Annual Meeting highlighted rapid advances in gene editing for hematologic diseases, with increasing emphasis on precision editing and early exploration of in vivo delivery strategies. Beyond technological development, several measurab...

Familial tailgut cysts in two sisters presenting with sacral dimple sign: a case report

Tailgut cysts are rare congenital cystic lesions arising from remnants of the embryological postanal primitive gut. Familial clustering of tailgut cysts has been rarely reported, and the association with sacral dimple sign as an early diagnostic indicator remains underexplored. W...